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Cancer Moonshot 2020: a new march of clinical and translational medicine
(Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 10, 2016 Category: Internal Medicine Authors: Xiangdong Wang Source Type: research

Localization of tamoxifen in human breast cancer tumors by MALDI mass spectrometry imaging
Tamoxifen is used in endocrine treatment of breast cancer to inhibit estrogen signaling. A set of stratified ER-positive and ER-negative tumor sections was subjected to manual deposition of tamoxifen solution ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 10, 2016 Category: Internal Medicine Authors: Ákos Végvári, Alexander S. Shavkunov, Thomas E. Fehniger, Dorthe Grabau, Emma Niméus and György Marko-Varga Source Type: research

Shortened leukocyte telomere length in type 2 diabetes mellitus: genetic polymorphisms in mitochondrial uncoupling proteins and telomeric pathways
Current debate in type 2 diabetes (T2DM) has focused on shortened leukocyte telomere length (LTL) as the result of a number of possible causes, including polymorphisms in mitochondrial uncoupling proteins (UCP... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 7, 2016 Category: Internal Medicine Authors: Yuling Zhou, Zhixin Ning, Yvonne Lee, Brett D. Hambly and Craig S. McLachlan Source Type: research

Biomarkers of early chronic obstructive pulmonary disease (COPD) in smokers and former smokers. Protocol of a longitudinal study
Chronic obstructive pulmonary disease (COPD) is an irreversible disease, diagnosed predominantly in smokers. COPD is currently the third leading cause of death worldwide. Far more than 15 % of smokers get COPD... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 7, 2016 Category: Internal Medicine Authors: Mikael Truedsson, Johan Malm, K. Barbara Sahlin, May Bugge, Elisabet Wieslander, Magnus Dahlbäck, Roger Appelqvist, Thomas E. Fehniger and György Marko-Varga Source Type: research

Horizontal transfer of RNA and proteins between cells by extracellular microvesicles: 14 years later
Extracellular microvesicles (ExMVs) are part of the cell secretome, and evidence has accumulated for their involvement in several biological processes. Fourteen years ago our team demonstrated for the first ti... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 4, 2016 Category: Internal Medicine Authors: Mariusz Z. Ratajczak and Janina Ratajczak Source Type: research

Erratum to: Integrated EpCAM-independent subtraction enrichment and iFISH strategies to detect and classify disseminated and circulating tumors cells
(Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 9, 2016 Category: Internal Medicine Authors: Peter Ping Lin Source Type: research

Randomized trial of acupoints herbal patching in Sanfu Days for asthma in clinical remission stage
Although China has a long history of using acupoints herbal patching (acupoints herbal patching means applying herbal patch on special acupoints to stimulate skin to form blisters, hyperemia, and even suppurat... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 4, 2016 Category: Internal Medicine Authors: Libing Zhu, Wei Zhang, Vivian Wong, Ziea Eric, Lixing Lao, Kwaiching Lo, Waichung Chan, To Yau and Lei Li Source Type: research

Randomized trial of acupoints herbal patching in Sanfu Days for asthma in clinical remission stage
This study investigated the efficacy and safety of acupoints herbal patching compared with placebo in participants with asthma in clinical remission stage. Methods: We enrolled participants with asthma in clinical remission stage, above 13 years old and both genders in a randomized, double-blind and placebo-control trial at clinical center, School of Chinese Medicine, The University of Hong Kong to assess the effectiveness and safety of acupoints herbal patching, as compared with placebo, when added to guidelines-based therapy. The trial was conducted for three times (these three times were 19 July, 29 July and 8 August 2...
Source: Clinical and Translational Medicine - February 4, 2016 Category: Internal Medicine Authors: Libing ZhuWei ZhangVivian WongZiea EricLixing LaoKwaiching LoWaichung ChanTo YauLei Li Source Type: research

Erratum to: Benchmarks for ethically credible partnerships between industry and academic health centers: beyond disclosure of financial conflicts of interest
(Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 29, 2016 Category: Internal Medicine Authors: Eric M. Meslin, Joshua B. Rager, Peter H. Schwartz, Kimberly A. Quaid, Margaret M. Gaffney, Jon Duke and William M. Tierney Source Type: research

Erratum to: Benchmarks for ethically credible partnerships between industry and academic health centers: beyond disclosure of financial conflicts of interest
No description available (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 29, 2016 Category: Internal Medicine Authors: Eric MeslinJoshua RagerPeter SchwartzKimberly QuaidMargaret GaffneyJon DukeWilliam Tierney Source Type: research

A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors
Since Otto Warburg made the first observation that tumor cells exhibit altered metabolism and bioenergetics in the 1920s, many scientists have tried to further the understanding of tumor bioenergetics. Particularly, in the past decade, the application of the state-of the-art metabolomics and genomics technologies has revealed the remarkable plasticity of tumor metabolism and bioenergetics. Firstly, a wide array of tumor cells have been shown to be able to use not only glucose, but also glutamine for generating cellular energy, reducing power, and metabolic building blocks for biosynthesis. Secondly, many types of cancer ce...
Source: Clinical and Translational Medicine - January 26, 2016 Category: Internal Medicine Authors: Md AlamSneha LalKeely FitzGeraldLi Zhang Source Type: research

A novel, clinically relevant use of a piglet model to study the effects of anesthetics on the developing brain
Anesthesia-induced neurotoxicity research in the developing brain must rely upon an unimpeachable animal model and a standardized treatment approach. In this manner, identification of mechanisms of action may ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 12, 2016 Category: Internal Medicine Authors: Emmett E. Whitaker, Bruno Bissonnette, Andrew D. Miller, Tanner L. Koppert, Joseph D. Tobias, Christopher R. Pierson and Fievos L. Christofi Source Type: research

A novel, clinically relevant use of a piglet model to study the effects of anesthetics on the developing brain
Conclusions: This study represents the first novel use of a clinically relevant neonatal piglet model to study anesthesia effects on the developing brain. LPS induces neuroinflammation, and this is a potential mechanism for LPS and perhaps isoflurane in causing a change in progenitor cell distribution. We postulate that the isoflurane-induced change in glial progenitor cell distribution could have important implications for cell differentiation, maturation and neural circuit behavior in the rapidly developing brain. (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 12, 2016 Category: Internal Medicine Authors: Emmett WhitakerBruno BissonnetteAndrew MillerTanner KoppertJoseph TobiasChristopher PiersonFievos Christofi Source Type: research

Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma
Conclusions: These preclinical studies suggest that targeting p53 through PLK-1 is an attractive chemotherapy strategy warranting further investigation in adrenocortical cancer. (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 11, 2016 Category: Internal Medicine Authors: Kimberly BusseyAditi BapatClaire LinnehanMelissa WandoloskiErica DastrupErik RogersPaul GonzalesMichael Demeure Source Type: research