A novel, clinically relevant use of a piglet model to study the effects of anesthetics on the developing brain
Conclusions:
This study represents the first novel use of a clinically relevant neonatal piglet model to study anesthesia effects on the developing brain. LPS induces neuroinflammation, and this is a potential mechanism for LPS and perhaps isoflurane in causing a change in progenitor cell distribution. We postulate that the isoflurane-induced change in glial progenitor cell distribution could have important implications for cell differentiation, maturation and neural circuit behavior in the rapidly developing brain.
Source: Clinical and Translational Medicine - Category: Internal Medicine Authors: Emmett WhitakerBruno BissonnetteAndrew MillerTanner KoppertJoseph TobiasChristopher PiersonFievos Christofi Source Type: research
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