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Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age-related disorders
Nicotinamide adenine dinucleotide (NAD+) is a central metabolic cofactor in eukaryotic cells that plays a critical role in regulating cellular metabolism and energy homeostasis. NAD+ in its reduced form (i.e. NAD... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 27, 2016 Category: Internal Medicine Authors: Sarika Srivastava Source Type: research

Integrated information for integrated care in the general practice setting in Italy: using social network analysis to go beyond the diagnosis of frailty in the elderly
Frailty has been defined in different ways and several diagnostic tools exist, but most of them are not applicable in routine primary care. Nonetheless, general practitioners (GPs) have a natural advantage in ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 27, 2016 Category: Internal Medicine Authors: Michela Franchini, Stefania Pieroni, Loredana Fortunato, Tamara Knezevic, Michael Liebman and Sabrina Molinaro Source Type: research

Mitochondria, cholesterol and cancer cell metabolism
Given the role of mitochondria in oxygen consumption, metabolism and cell death regulation, alterations in mitochondrial function or dysregulation of cell death pathways contribute to the genesis and progressi... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 25, 2016 Category: Internal Medicine Authors: Vicent Ribas, Carmen Garc ía-Ruiz and José C. Fernández-Checa Source Type: research

Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update
This is an update to our 2012 publication on clinical trial considerations on male contraception and collection of pregnancy information from female partner, after critical review of recent (draft) guidances r... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 25, 2016 Category: Internal Medicine Authors: Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Gu érard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger Source Type: research

Researchers ’ perspectives on pediatric obesity research participant recruitment
Childhood obesity prevalence has tripled over the last three decades. Pediatric obesity has important implications for both adult health as well as the United States economy. In order to combat pediatric obesi... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 23, 2016 Category: Internal Medicine Authors: Yasha Parikh, Maryann Mason and Karen Williams Source Type: research

Researchers’ perspectives on pediatric obesity research participant recruitment
Childhood obesity prevalence has tripled over the last three decades. Pediatric obesity has important implications for both adult health as well as the United States economy. In order to combat pediatric obesi... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 23, 2016 Category: Internal Medicine Authors: Yasha Parikh, Maryann Mason and Karen Williams Source Type: research

Electrical stimulation towards melanoma therapy via liquid metal printed electronics on skin
We proposed a method of using electrical stimulation for treatment of malignant melanoma through directly spray-printing liquid metal on skin as soft electrodes to deliver low intensity, intermediate frequency... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 23, 2016 Category: Internal Medicine Authors: Jun Li, Cangran Guo, Zhongshuai Wang, Kai Gao, Xudong Shi and Jing Liu Source Type: research

Building the basis for proteomics in personalized medicine for targeted treatment
(Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 20, 2016 Category: Internal Medicine Authors: Ho Jeong Kwon, Thomas E. Fehniger and György Marko-Varga Source Type: research

Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong
Chromosomal microarray offers superior sensitivity for identification of submicroscopic copy number variants (CNV) and it is advocated to be the first tier genetic testing for patients with autism spectrum dis... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 16, 2016 Category: Internal Medicine Authors: Wai-Kwan Siu, Ching-Wan Lam, Chloe Miu Mak, Elizabeth Tak-Kwong Lau, Mary Hoi-Yin Tang, Wing-Fai Tang, Rachel Sui-Man Poon-Mak, Chi-Chiu Lee, Se-Fong Hung, Patrick Wing-Leung Leung, Karen Ling Kwong, Eric Kin-Cheong Yau, Grace Sui-Fun Ng, Nai-Chung Fong a Source Type: research

Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency
Pleural infection affects about 65,000 patients annually in the US and UK. In this and other forms of pleural injury, mesothelial cells (PMCs) undergo a process called mesothelial (Meso) mesenchymal transition... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 13, 2016 Category: Internal Medicine Authors: Torry A. Tucker, Ann Jeffers, Jake Boren, Brandon Quaid, Shuzi Owens, Kathleen B. Koenig, Yoshikazu Tsukasaki, Galina Florova, Andrey A. Komissarov, Mitsuo Ikebe and Steven Idell Source Type: research

Mitochondrial transplantation for therapeutic use
Mitochondria play a key role in the homeostasis of the vast majority of the body’s cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuation or obst... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 29, 2016 Category: Internal Medicine Authors: James D. McCully, Sidney Levitsky, Pedro J. del Nido and Douglas B. Cowan Source Type: research

Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease
The major therapeutic benefit of hydroxyurea, the only FDA-approved pharmacologic treatment for sickle cell disease (SCD), is directly related to fetal hemoglobin (HbF) production that leads to significant red... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 7, 2016 Category: Internal Medicine Authors: Gift Dineo Pule, Shaheen Mowla, Nicolas Novitzky and Ambroise Wonkam Source Type: research

Energy metabolic dysfunction as a carcinogenic factor in cancer cells
Cancer, as a leading cause of death, has attracted enormous public attention. Reprogramming of cellular energy metabolism is deemed to be one of the principal hallmarks of cancer. In this article, we reviewed ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 6, 2016 Category: Internal Medicine Authors: Yongyan Sun, Zhenhua Shi, Huiyong Lian and Peng Cai Source Type: research

Genomics, microRNA, epigenetics, and proteomics for future diagnosis, treatment and monitoring response in upper GI cancers
One major objective for our evolving understanding in the treatment of cancers will be to address how a combination of diagnosis and treatment strategies can be used to integrate patient and tumor variables wi... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 6, 2016 Category: Internal Medicine Authors: Björn L. D. M. Brücher, Yan Li, Philipp Schnabel, Martin Daumer, Timothy J. Wallace, Rainer Kube, Bruno Zilberstein, Scott Steele, Jan L. A. Voskuil and Ijaz S. Jamall Source Type: research

Depurinating estrogen-DNA adducts, generators of cancer initiation: their minimization leads to cancer prevention
Estrogens can initiate cancer by reacting with DNA. Specific metabolites of endogenous estrogens, the catechol estrogen-3,4-quinones, react with DNA to form depurinating estrogen-DNA adducts. Loss of these add... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 15, 2016 Category: Internal Medicine Authors: Ercole L. Cavalieri and Eleanor G. Rogan Source Type: research