The expression of CD123 can decrease with basophil activation: implications for the gating strategy of the basophil activation test
Conclusions
Basophils of a subset of patients down-regulate CD123 with activation. The use of CD203c before gating on CD123+/HLA-DR− cells or in isolation ensures the identification of the entire basophil population and accurate assessment of basophil activation, with important diagnostic implications. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 31, 2016 Category: Allergy & Immunology Source Type: research
Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review
Conclusion
The findings from this review will be used to inform the development of recommendations for EAACI’s Guidelines on AIT. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 22, 2016 Category: Allergy & Immunology Source Type: research
Basophil activation test: food challenge in a test tube or specialist research tool?
Abstract
Oral food challenge (OFC) is the gold-standard to diagnose food allergy; however, it is a labour and resource-intensive procedure with the risk of causing an acute allergic reaction, which is potentially severe. Therefore, OFC are reserved for cases where the clinical history and the results of skin prick test and/or specific IgE do not confirm or exclude the diagnosis of food allergy. This is a significant proportion of patients seen in Allergy clinics and results in a high demand for OFC. The basophil activation test (BAT) has emerged as a new diagnostic test for food allergy. With high diagn...
Source: Clinical and Translational Allergy - March 15, 2016 Category: Allergy & Immunology Source Type: research
Tolerability of the SQ-standardised grass sublingual immunotherapy tablet in patients treated with concomitant allergy immunotherapy: a non-interventional observational study
Conclusions
In comparison to data from previous studies no increase in frequency of AEs or change in the tolerability profile was observed when SLIT with the SQ® grass SLIT-tablet was administered with concomitant SCIT or SLIT. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 8, 2016 Category: Allergy & Immunology Source Type: research
Genetic susceptibility for cow’s milk allergy in Dutch children: the start of the allergic march?
Conclusion
We significantly associated two SNPs with CMA, suggesting that variation in the TLR6 and IL2 genes contribute to the expression of CMA. In addition, since TLR6 and IL2 were earlier associated with other later onset allergies, this also favours the “allergic march” hypothesis. We observed more FLG mutations in the CMA-group, albeit we found no statistical significant enrichment of FLG mutations. Further studies are necessary to investigate the role of common variants and FLG or other skin barrier gene mutations in CMA. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 3, 2016 Category: Allergy & Immunology Source Type: research
