The feasibility of an allergy management support system (AMSS) for IgE-mediated allergy in primary care
ConclusionThe AMSS can be considered to be feasible for primary care. GPs tend to follow the AMSS recommendations. The AMSS may contribute to the empowerment of GPs to better manage allergy patients in primary care.Trial registration ISRCTN ISRCTN36780877. Registered 23 November 2017 (retrospectively registered) (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 29, 2018 Category: Allergy & Immunology Source Type: research
Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis
ConclusionsIntratonsillar T cell and interferon gene expressions appeared to be relatively stable for both tonsillar hypertrophy and recurrent tonsillitis. Of the studied cytokines, only newly discovered anti-inflammatory cytokine IL-37, was independently associated with tonsillar hypertrophy showing slightly stronger anti-inflammatory response in these patients. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 22, 2018 Category: Allergy & Immunology Source Type: research
An EAACI task force report: recognising the potential of the primary care physician in the diagnosis and management of drug hypersensitivity
We describe the common patterns of DHRs and signs of its progression, as well as the indications and contraindications for referring the patient to an allergist. The diagnostic process is described and the possible tests are discussed, which often depend on the drug involved and the type of DHR suspected. We also describe recommendations regarding the avoidance of medication suspected to have caused the reaction and the use of alternatives. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 10, 2018 Category: Allergy & Immunology Source Type: research
Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007 –2012
ConclusionsA prevalent overlap of commonly reported asthma phenotypes was observed among asthma patients from the general population, with implications for objective asthma outcomes. A broader approach may be required to better characterize asthma patients and prevent poor asthma outcomes. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 4, 2018 Category: Allergy & Immunology Source Type: research
7th International Symposium on Molecular Allergology (ISMA 2017)
(Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 3, 2018 Category: Allergy & Immunology Source Type: research
Consideration of methods for identifying mite allergens
AbstractHouse dust mites are small arthropods that produce proteins —found in their feces, body parts, and eggs—that are major triggers of human allergies worldwide. The goal of this review is to describe the current methods used to identify these allergens. A literature search for allergen identification methods employed between 1995 and 2016 revealed multiple techniques that can be broadly grouped into discovery and confirmation phases. The discovery phase employs screening for mite proteins that can bind IgEs in sera from animals or patients allergic to dust mites. The confirmation phase employs biochemical methods ...
Source: Clinical and Translational Allergy - April 27, 2018 Category: Allergy & Immunology Source Type: research
Diverse expression of TNF- α and CCL27 in serum and blister of Stevens–Johnson syndrome/toxic epidermal necrolysis
ConclusionsOur study demonstrated roles of CCL27 and TNF- α in promoting the course of SJS/TEN. CCL27 may act early in the course of disease, via the circulation, whereas TNF-α acts throughout the course of disease, in skin lesions. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - April 20, 2018 Category: Allergy & Immunology Source Type: research
The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC): verification of nasal allergen challenge procedures in a study utilizing an investigational immunotherapy for cat allergy
ConclusionsThis study supports the validity of the AR-CIC ’s optimised NAC protocol for conducting research of the potential efficacy of novel therapeutics in multi-centre studies.Trial registration Both studies reported herein were registered clinicaltrials.gov (NCT01383590 and NCT01383603) (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - April 12, 2018 Category: Allergy & Immunology Source Type: research
Pollen and spore monitoring in the world
ConclusionsThe map shows the current situation of pollen and spore monitoring and facilitates collaboration among those individuals who are interested in pollen and spore counts. It might also help to improve the monitoring of biological particles up to the current level employed for non-biological components. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - April 4, 2018 Category: Allergy & Immunology Source Type: research
Airborne protein concentration: a key metric for type 1 allergy risk assessment —in home measurement challenges and considerations
ConclusionsVery low airborne concentrations of allergenic proteins in home settings can be successfully quantified using commercially available pumps and immunoassays. Considering the greater relevance of air sampling to human exposure of the respiratory tract and its other advantages, wider use of standardised, sensitive techniques to measure low airborne protein concentrations and how they influence development of allergic sensitisation and symptoms could accelerate our understanding of human dose –response relationships and refine our knowledge of thresholds of allergic sensitisation and elicitation via the respirator...
Source: Clinical and Translational Allergy - March 26, 2018 Category: Allergy & Immunology Source Type: research
Effectiveness of icatibant for treatment of hereditary angioedema attacks is not affected by body weight: findings from the Icatibant Outcome Survey, a cohort observational study
ConclusionOverall, icatibant was comparatively effective in treating attacks in patients across all BMI groups.Trial registration NCT01034969. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 23, 2018 Category: Allergy & Immunology Source Type: research
The kinase LRRK2 is differently expressed in chronic rhinosinusitis with and without nasal polyps
ConclusionLRRK2 and NRON may play different role in CRSsNP and CRSwNP. The molecular mechanisms identified here may aid in the design of novel therapeutic strategies to improve clinical outcomes. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 12, 2018 Category: Allergy & Immunology Source Type: research
On-demand intermittent beclomethasone is effective for mild asthma in Brazil
ConclusionClinicians might consider intermittent inhaled steroid therapy as a therapeutic regimen for mild persistent asthma.Trial registration The Portuguese and English versions of the study protocol were submitted, approved, and registered in the Brazilian Network Platform for Clinical Trials (http://www.ensaiosclinicos.gov.br) under the primary identifier number “RBR-3gbyhk”. This platform is part of the Primary Registries in the World Health Organization Registry Network, where the trial is registered under the following Universal Trial Number: 1111-1149-4774 (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 5, 2018 Category: Allergy & Immunology Source Type: research
Publication trends of Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy journals: a MeSH term-based bibliometric analysis
AbstractWe performed a MeSH term-based bibliometric analysis aiming to assess the publication trends of EAACI journals, namely Allergy, Pediatric Allergy and Immunology (PAI) (from 1990 to 2015) and Clinical and Translational Allergy (CTA) (from its inception in 2011 to 2015). We also aimed to discuss the impact of the creation of CTA in the publication topics of Allergy and PAI. We analysed a total of 1973 articles and 23,660 MeSH terms. Most MeSH terms in the three journals fell in the category of “basic immunology and molecular biology” (BIMB). During the studied period, we observed an increase in the proportion of ...
Source: Clinical and Translational Allergy - February 22, 2018 Category: Allergy & Immunology Source Type: research
Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma
ConclusionsThe findings of this study indicate a potential role for IL-25 in allergen-induced trafficking of EoP to the airways and local differentiation promoting tissue eosiniophilia in asthmatic responses. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 13, 2018 Category: Allergy & Immunology Source Type: research
