Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort
ConclusionsMultimorbidity is associated with polysensitization especially in children compared with adults in Polish population cohort. New insights into single disease patterns were found: bronchial asthma is the strongest risk factor for the development of multimorbidity in comparison with allergic rhinitis and atopic dermatitis. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 11, 2019 Category: Allergy & Immunology Source Type: research
Health-related quality of life worsens by school age amongst children with food allergy
ConclusionOlder children and those with severe food allergy have worse HRQL. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 7, 2019 Category: Allergy & Immunology Source Type: research
Stepwise approach towards adoption of allergen immunotherapy for allergic rhinitis and asthma patients in daily practice in Belgium: a BelSACI-Abeforcal-EUFOREA statement
AbstractAllergic rhinitis (AR) affects 23 –30% of the European population with equal prevalence reported in Belgium. Despite guidelines on the correct use of effective treatment, up to 40% of AR patients remain uncontrolled. Allergen immunotherapy (AIT) has been shown to improve the level of control up to 84% of patients being controlled by AIT. Recently, new guidelines for AIT have been published, supporting the clinical evidence for effectiveness of various subcutaneous and sublingual products for AIT in patients who are allergic to airborne allergens. AIT in AR patients not only reduces nasal and/or ocular symptoms bu...
Source: Clinical and Translational Allergy - February 4, 2019 Category: Allergy & Immunology Source Type: research
The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients
ConclusionsAutoantibody profiling of IgG-reactivity using microarray technology revealed an autoantibody-based subgroup in patients with AD. The four identified autoantigens and especially S100A12 could, if characterized further, increase the understanding of different pathogenic mechanisms behind AD and thereby enable better treatment. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - January 31, 2019 Category: Allergy & Immunology Source Type: research
Vilnius Declaration on chronic respiratory diseases: multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases
ConclusionThe Vilnius Declaration represents an important step for the fight against air pollution in chronic respiratory diseases globally and has a clear strategic relevance with regard to the EU Health Strategy as it will bring added value to the existing public health knowledge. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - January 28, 2019 Category: Allergy & Immunology Source Type: research
The roadmap for the Allergology specialty and allergy care in Europe and adjacent countries. An EAACI position paper
AbstractThe high prevalence of allergic diseases warrants for sufficient health care provisions available to patients with allergic diseases. Allergy care should be delivered by well-trained specialists. However, the current status of allergy care is not well documented. For this reason a survey among European and a few non-European countries was launched by the National Allergy Society Committee from the European Academy of Allergy and Clinical Immunology and the Union Europ éenne des Médecins Spécialistes section and board of Allergology. The survey shows that in the vast majority of countries allergy care services ar...
Source: Clinical and Translational Allergy - January 24, 2019 Category: Allergy & Immunology Source Type: research
A specific synbiotic-containing amino acid-based formula in dietary management of cow ’s milk allergy: a randomized controlled trial
ConclusionBeneficial effects of this AAF including specific synbiotics on microbiota composition were observed over 26 weeks, and shown suitable for dietary management of infants with non-IgE-mediated CMA.Trial Registration NTR3979 (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - January 15, 2019 Category: Allergy & Immunology Source Type: research
Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review
AbstractThere is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While some of this heterogeneity of response is due to adherence and environmental causes, genetic variation also influences response to treatment and genetic markers may help guide treatment. Over the past years, researchers have investigated the relationship between a large number of genetic variations and response to ICS by performing pharmacogenomic studies. In this systematic review we will provide a summary of recent pharmacogenomic studies on ICS and discuss the latest insight into the potential functional role of identifie...
Source: Clinical and Translational Allergy - January 9, 2019 Category: Allergy & Immunology Source Type: research
Dual exposure to smoking and household air pollution is associated with an increased risk of severe asthma in adults in Brazil
ConclusionsExposure to household pollution is associated with poorer control, greater severity, and poorer pulmonary function; double-exposed individuals have a greater risk of severe asthma and decreased lung function than those exposed only to household pollution. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 10, 2018 Category: Allergy & Immunology Source Type: research
Relationship between vitamin D and chronic spontaneous urticaria: a systematic review
ConclusionCSU patients had significantly lower serum vitamin D levels than the controls in most studies. However, the results did not prove causation, and the mechanisms were not clearly explained. Despite the scarcity of available studies, this systematic review showed that a high dosage of vitamin D supplementation for 4 –12 weeks might help to decrease the disease activity in some CSU patients. Well-designed randomized placebo-controlled studies are needed to determine the cut-off levels of vitamin D for supplementation and treatment outcomes. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 4, 2018 Category: Allergy & Immunology Source Type: research
Elevated expression of IL-17RB and ST2 on myeloid dendritic cells is associated with a Th2-skewed eosinophilic inflammation in nasal polyps
ConclusionsIncreased expressions of IL-17RB and ST2 on mDCs are associated with enhanced local Th2 inflammation in NP, suggesting that mDCs might play a role in IL-25- and IL-33-induced type 2 responses and eosinophilic inflammation in NP. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 29, 2018 Category: Allergy & Immunology Source Type: research
Highlights and recent developments in airway diseases in EAACI journals (2017)
AbstractThe European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members. There was substantial progress in 2017 in the identification of basic mechanisms of allergic and respiratory disease and the translation of these mechanisms into clinics. Better understanding of molecular and cellular mechanisms...
Source: Clinical and Translational Allergy - November 27, 2018 Category: Allergy & Immunology Source Type: research
Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study) —protocol for a randomized controlled trial
This study is a multi-center, pragmatic, two-parallel group, assessor-blind, superiority, individually randomized controlled trial. Atopic dermatitis infants (N = 650) 7–13 weeks old who develop an itchy rash within the previous 28 days are randomly assigned to the aggressive treatment or the conventional treatment in a 1:1 ratio. The primary outcome is oral food challenge-proven IgE-mediated hen’s egg allergy at the age of 28 weeks.DiscussionThis is a novel pragmatic RCT study to examine the efficacy of early aggressive treatment for atopic dermatitis to prevent later food allergy. If our hypothesis is correct...
Source: Clinical and Translational Allergy - November 23, 2018 Category: Allergy & Immunology Source Type: research
Identification of Pen m 4 as a potential cause of occupational asthma to Gammarus shrimp
We present the case of a 34-year-old male patient employed for 8 years in a company manufacturing and packaging animal feed. The patient developed occupational asthma to dry Gammarus powder. The diagnosis was confirmed by specific bronchial provocation test. The determination of specific IgE antibodies was positive for Pen m 4, a sarcoplasmic calcium binding pr otein, with a level of 6.7 ISU-E. The sensitization to Pen m 4 described here may identify a new allergen causing occupational asthma in these workers. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 9, 2018 Category: Allergy & Immunology Source Type: research
Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites
ConclusionIn conclusion, the distribution of AAT genotypes in HDM allergic asthmatic patients did not differ from those found in Spanish population. Neither severe ATTD or deficient AAT genotypes appear to confer different clinical expression of asthma. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 2, 2018 Category: Allergy & Immunology Source Type: research
