Standardization of double blind placebo controlled food challenge with soy within a multicentre trial
ConclusionsWe present the hitherto largest group of adults with Bet v 1 and Gly m 4 sensitization being investigated by DBPCFC. In this type of food allergy evaluation of DBPCFC outcome should not only include monitoring of objective signs but also scoring of subjective symptoms. Our data may contribute to standardize DBPCFC in pollen-related food allergy in multicentre settings.Trial registrationEudraCT: 2009-011737-27. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 6, 2016 Category: Allergy & Immunology Source Type: research
4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research
6th International Symposium on Molecular Allergology (ISMA)
Table of contentsORAL ABSTRACTSSymposium 1: Biochemistry, structure and environment of the allergen: what makes a protein an allergen?O1 Two cell-membrane peptidases carrying galactose-alpha-1,3-galactose are implicated in delayed anaphylactic reactions upon pork kidney ingestion in patients with IgE-antibodies to alpha-GalChristiane Hilger, Kyra Swiontek, J örg Fischer, François Hentges, Christiane Lehners, Martine Morisset, Bernadette Eberlein, Tilo Biedermann, Markus OllertO2 Structure solution of Pla l 1 suggests similar folding of Ole e 1-like family members but distinct immunological propertiesSabrina Wildner, Tere...
Source: Clinical and Translational Allergy - September 30, 2016 Category: Allergy & Immunology Source Type: research
Impaired health-related quality of life in adolescents with allergy to staple foods
ConclusionsAs ascertained via a food allergy-specific questionnaire, adolescents with staple food allergy report poorer than average HRQL, specifically in relation to emerging independence and the need for support. Girls have clinically worse HRQL than boys. The number and type of previous symptoms and history of anaphylaxis were not associated with worse HRQL. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 29, 2016 Category: Allergy & Immunology Source Type: research
Proficiency testing of skin prick testers as part of a quality assurance system
ConclusionThe described histamine testing provides an objective system for the evaluation of basic skin test quality assessment standards especially for documentation in scientific studies. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 20, 2016 Category: Allergy & Immunology Source Type: research
Cost utility analysis of the SQ ® HDM SLIT-tablet in house dust mite allergic asthma patients in a German setting
ConclusionThis analysis indicates that ACARIZAX plus pharmacotherapy is cost-effective compared with placebo plus pharmacotherapy for house dust mite allergic asthma patients in Germany. If a disease-modifying effect can be proven the results of this analysis may underestimate the true benefits of ACARIZAX. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 6, 2016 Category: Allergy & Immunology Source Type: research
A qualitative study of the allergy testing experiences, views and preferences of adult patients
ConclusionsThe patient preferred method of allergy testing was skin prick testing rather than in vitro allergen specific IgE testing. However, most patients were accepting of either testing modality because their desire to confirm or exclude an allergic trigger overrode any perceived disadvantages of the test method.Trial registrationNot applicable as study descriptive and qualitative. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - August 29, 2016 Category: Allergy & Immunology Source Type: research
7th Drug hypersensitivity meeting: part two
Table of contentsPoster walk 11: miscellaneous drug hypersensitivity 2 (P92 –P94, P96–P101)P92 16 years of experience with proton pump inhibitors (PPIs)Javier Dionicio Elera, Cosmin Boteanu, Maria Aranzazu Jimenez Blanco, Rosario Gonzalez-Mendiola, Irene Carrasco Garc ía, Antonio Alvarez, Jose Julio Laguna MartinezP93 Allergy evaluation of quinolone induced adverse reactionsJaume Mart í Garrido, Carla Torán Barona, Carolina Perales Chorda, Ramón López Salgueiro, Miguel Díaz Palacios, Dolores Hernández Fernández De RojasP94 Bupropion-induced acute urticaria and angioedema, a case reportEmre Ali Acar, Ayse Akta...
Source: Clinical and Translational Allergy - August 24, 2016 Category: Allergy & Immunology Source Type: research
7th drug hypersensitivity meeting: part one
Table of contentsOral AbstractsO1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TENDaniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir PirmohamedO2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture?Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel YerlyO3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivityRebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, Davi...
Source: Clinical and Translational Allergy - August 24, 2016 Category: Allergy & Immunology Source Type: research
Body mass index and physical activity in early childhood are associated with atopic sensitization, atopic dermatitis and asthma in later childhood
ConclusionsBMI and physical activity in early childhood were associated with atopic sensitization, atopic dermatitis and asthma in later childhood. Larger cohorts with repeated measurements of both predictors and outcomes are required to further elucidate this issue.Trial registration Our study was observational without any clinical intervention on the participants. Therefore, no trial registration number is available (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - August 23, 2016 Category: Allergy & Immunology Source Type: research
Improvement of sleep in patients with chronic idiopathic/spontaneous urticaria treated with omalizumab: results of three randomized, double-blind, placebo-controlled studies
ConclusionsImprovement in sleep was reported after the first dose of omalizumab. Sleep continued to improve throughout the active treatment period. Patients receiving omalizumab 300 mg achieved greater improvement in sleep than those in other treatment arms.Trial registration ClinicalTrials.gov, NCT01287117 (ASTERIA I), NCT01292473 (ASTERIA II), and NCT01264939 (GLACIAL) (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - August 17, 2016 Category: Allergy & Immunology Source Type: research
Different risk factor patterns for adult asthma, rhinitis and eczema: results from West Sweden Asthma Study
ConclusionsThere are different risk factor patterns for asthma, rhinitis and eczema in adults but some risk factors are overlapping between some of the conditions. The effect of mutable risk factors should be assessed further in longitudinal studies. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - August 3, 2016 Category: Allergy & Immunology Source Type: research
Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " >
Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR ( < em class= " a-plus-plus " > Contre les MAladies Chroniques pour un VIeillissement Actif < /em > ) and ARIA (Allergic Rhinitis and its Impact on Asthma)...
Source: Clinical and Translational Allergy - July 28, 2016 Category: Allergy & Immunology Source Type: research
Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediated by breast milk TSLP or TGF- β
Conclusions < /h3 > < p class= " a-plus-plus " > Whilst maternal probiotic supplementation resulted in higher breast milk concentrations of TLSP at 10 days postpartum, this does not appear to be a mechanism for prevention of AD by maternal probiotics. < /p > < p class= " a-plus-plus " > < em class= " a-plus-plus " > Trial registration < /em > The original trial protocol is registered in ClinicalTrials.gov (identifier NCT00159523) < /p > < /span > (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 21, 2016 Category: Allergy & Immunology Source Type: research
Optimizing diagnostic tests for persulphate-induced respiratory diseases
Conclusions
The proposed method for performing SIC showed a high specificity for detecting persulphate-induced asthma and rhinitis. The rapid SIC was able to produce positive nasal and bronchial responses in symptomatic hairdressers without any severe reactions occurring. SPTs and HRTs cannot predict asthma or rhinitis caused by persulphates. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 20, 2016 Category: Allergy & Immunology Source Type: research
