Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children
ConclusionAlthough co-sensitisation between cashew nut and pistachio nut was observed in 98%, pistachio nut sensitisation was only clinically relevant in 34% of the children. Therefore, a challenge test with pistachio nut is recommended in children with cashew nut and pistachio nut sensitisation.Trial registration The study was registered in the Dutch trial register (registration number 3572) on 10 August 2012 (retrospectively registered) (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 19, 2017 Category: Allergy & Immunology Source Type: research
Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America
Abstract
Drug hypersensitivity reactions (DHRs) affect an unknown proportion of the general population, and are an important public health problem due to their potential to cause life-threatening anaphylaxis and rare severe cutaneous allergic reactions. DHR evaluations are frequently needed in both ambulatory and hospital settings and have a complex diagnosis that requires a detailed clinical history and other tests that may include in vitro tests and in vivo procedures such as skin tests and drug provocation tests. Although over the years both European and U.S. experts have published statements on general procedures fo...
Source: Clinical and Translational Allergy - March 12, 2017 Category: Allergy & Immunology Source Type: research
Galectin-3: an early predictive biomarker of modulation of airway remodeling in patients with severe asthma treated with omalizumab for 36 months
ConclusionsOur results showed that omalizumab can be considered a disease-modifying treatment in OR. The proteomic signatures confirmed the presence of Gal-3 at baseline to be a biomarker of long-term reduction in bronchial RBM thickness, eosinophilic inflammation, and muscular and fibrotic components in omalizumab-treated patients with severe asthma. Our findings suggest a possible relationship between Gal-3 positivity and improved pulmonary function. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 8, 2017 Category: Allergy & Immunology Source Type: research
Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
(Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 19, 2017 Category: Allergy & Immunology Source Type: research
Effectiveness and safety of antihistamines up to fourfold or higher in treatment of chronic spontaneous urticaria
ConclusionUp-dosing antihistamines higher than fourfold dosage seems a feasible therapeutic option with regards to effectiveness and safety. The need for third line therapies could be decreased by 49%, with a very limited increase of reported side effects. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 13, 2017 Category: Allergy & Immunology Source Type: research
Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA 2 LEN) Survey
Conclusion and clinical relevanceThere was no consistent evidence for an association of asthma or CRS with fruit and vegetable intake in this representative sample of European adults. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - January 26, 2017 Category: Allergy & Immunology Source Type: research
Looking forward to new targeted treatments for chronic spontaneous urticaria
AbstractThe introduction of omalizumab to the management of chronic spontaneous urticaria (CSU) has markedly improved the therapeutic possibilities for both, patients and physicians dealing with this disabling disease. But there is still a hard core of patients who do not tolerate or benefit from existing therapies and who require effective treatment. Novel approaches include the use of currently available drugs off-licence, investigational drugs currently undergoing clinical trials and exploring the potential for therapies directed at pathophysiological targets in CSU. Off-licence uses of currently available drugs include...
Source: Clinical and Translational Allergy - January 9, 2017 Category: Allergy & Immunology Source Type: research
Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid
We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients such as macrogols is needed, especially when allergy tests for the active drug is negative and in patients with a history of repeated anaphylaxis to seemingly unrelated drugs. To establish the correct diagnosis it is important to test with the exact formulation of the culprit drug, as well as all the ingredient...
Source: Clinical and Translational Allergy - January 9, 2017 Category: Allergy & Immunology Source Type: research
ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
AbstractThe Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA —disseminated and implemented in over 70 countries globally—is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vie...
Source: Clinical and Translational Allergy - December 29, 2016 Category: Allergy & Immunology Source Type: research
Cross-reactive LTP sensitization in food-dependent exercise-induced urticaria/anaphylaxis: a pilot study of a component-resolved and in vitro depletion approach
ConclusionsIn vitro immunodepletion might be a useful diagnostic tool in food dependent exercise induced urticaria/anaphylaxis with panallergen sensitization, particularly for identifying the culprit allergen and guiding dietary elimination recommendations. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 21, 2016 Category: Allergy & Immunology Source Type: research
Exploratory analysis of CD63 and CD203c expression in basophils from hazelnut sensitized and allergic individuals
ConclusionOur data indicate that the basophil activation test may provide information to better distinguish between sensitized and allergic subjects if several allergen concentrations are considered. CD203c expression displayed a better discrimination compared to CD63; therefore, its diagnostic value might be superior compared with CD63. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 12, 2016 Category: Allergy & Immunology Source Type: research
Immunoglobulin free light chains in adult atopic dermatitis patients do not correlate with disease severity
ConclusionThere are no differences in serum kappa Ig-FLC levels between adult patients suffering from moderate to severe AD compared to non-atopic controls. Moreover, serum levels of kappa Ig-FLCs cannot be used as a biomarker for disease severity in adult AD. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 5, 2016 Category: Allergy & Immunology Source Type: research
A mutually beneficial collaboration between the European Academy of Allergy and Clinical Immunology Junior Members and Clinical and Translational Allergy
AbstractThe European Academy of Allergy and Clinical Immunology (EAACI) Junior Members (JM) comprise the largest EAACI section with around 4000 clinicians and scientists under 35 years of age working in the field of allergy and clinical immunology. The Junior Member collaboration with Clinical and Translational Allergy Journal is a mutually beneficial relationship providing Junior Members of EAACI with excellent opportunities to publish their work in the Journal, enhance t heir visibility in their respective field, and get involved with Journal-related activities and processes. In the future, this collaboration will grow...
Source: Clinical and Translational Allergy - November 30, 2016 Category: Allergy & Immunology Source Type: research
Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies
AbstractAllergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Sant é). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unm...
Source: Clinical and Translational Allergy - November 22, 2016 Category: Allergy & Immunology Source Type: research
Hypothesis: may e-cigarette smoking boost the allergic epidemic?
(Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 14, 2016 Category: Allergy & Immunology Source Type: research
