MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence
AbstractmHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on s...
Source: Clinical and Translational Allergy - October 25, 2018 Category: Allergy & Immunology Source Type: research
A qualitative study exploring parents ’ experiences with epinephrine use for their child’s anaphylactic reaction
ConclusionsHandling reactions correctly provided parents with confidence to treat subsequent reactions. Witnessing the effects of an EAI and receiving positive feedback from health care providers further strengthened their confidence to quickly and competently intervene in future reactions. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 18, 2018 Category: Allergy & Immunology Source Type: research
Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey
The objective of this analysis was to evaluate the change over time in age at first symptoms, age at diagnosis, and delay in diagnosis using data from the Icatibant Outcome Survey (IOS). Patients with a diagnosis of C1-INH-HAE who were born before the year 1990 and who were diagnosed before they reached 25 years of age were included in the analysis. Both age at diagnosis and delay in diagnosis of C1-INH-HAE appear to decline with later decade of birth, despite wide variation across the countries assessed, suggesting that improved disease awareness causes increased rates of earlier diagnosis over tim e. Our findings demon...
Source: Clinical and Translational Allergy - October 12, 2018 Category: Allergy & Immunology Source Type: research
Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT
ConclusionsClinical outcome of AIT depends on induction of blocking antibodies able to prevent the patient ’s own IgE from allergen binding. Monitoring of clinical efficacy seems to be best achieved using the inhibition mediator release assay, as development of relevant blocking antibodies can be verified in a patient-tailored manner. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 8, 2018 Category: Allergy & Immunology Source Type: research
Atopic dermatitis in cats and dogs: a difficult disease for animals and owners
AbstractThe purpose of this review article is to give an overview of atopic dermatitis in companion animals and of recent developments including knowledge on immunological background, novel treatment options and difficulties in disease management. The prevalence of hypersensitivities seems to be increasing. The pathogenetic mechanisms are not fully understood, yet multiple gene abnormalities and altered immunological processes are involved. In dogs and cats, the diagnosis of atopic dermatitis is based on history, clinical examination and exclusion of other differential diagnoses. Intradermal testing or testing for serum al...
Source: Clinical and Translational Allergy - October 5, 2018 Category: Allergy & Immunology Source Type: research
Deep analysis of immune response and metabolic signature in children with food protein induced enterocolitis to cow ’s milk
ConclusionsIn CM-FPIES, both humoral and cellular specific immune responses are weak or absent, and this is not related to CM avoidance. A metabolomic signature was identified in patients with CM-FPIES that may be useful for the diagnosis and management of this disease. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 28, 2018 Category: Allergy & Immunology Source Type: research
Insulin allergy can be successfully managed by a systematic approach
ConclusionInsulin allergy can be managed by a systematic approach, and symptom relief is obtainable in most patients. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 25, 2018 Category: Allergy & Immunology Source Type: research
Normocomplementaemic urticarial vasculitis: effective treatment with omalizumab
We report two patients with normocomplementaemic urticarial vasculitis with impressive response to omalizumab. This contrasts recent reports on hypocomplementaemic urticarial vasculitis syndrome, highlighting the need for clinical trials of omalizumab in normocomplementaemic urticarial vasculitis. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 21, 2018 Category: Allergy & Immunology Source Type: research
POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project
AbstractAllergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, Asthma and Rhinitis) is a project of the European Institute of Innovation and Technology (EIT Health). It will use a freely-existing application for AR monitoring that has been tested in 23 countries (theAllergy Diary, iOS and Android, 17,000 users, TLR8). The Allergy Diary will be combined with a new tool allowing queries on allergen, pollen (TLR2), sleep quality and disorders (TRL2) as well as existing longitu...
Source: Clinical and Translational Allergy - September 17, 2018 Category: Allergy & Immunology Source Type: research
Calu-3 epithelial cells exhibit different immune and epithelial barrier responses from freshly isolated primary nasal epithelial cells in vitro
In conclusion, immune and barrier function differ between different epithelial cell types studied. As a consequence, care must be taken when interpreting data using different epithelial cell types. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 12, 2018 Category: Allergy & Immunology Source Type: research
