The expression of CD123 can decrease with basophil activation: implications for the gating strategy of the basophil activation test

Conclusions Basophils of a subset of patients down-regulate CD123 with activation. The use of CD203c before gating on CD123+/HLA-DR− cells or in isolation ensures the identification of the entire basophil population and accurate assessment of basophil activation, with important diagnostic implications.
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research