Genetic susceptibility for cow’s milk allergy in Dutch children: the start of the allergic march?

Conclusion We significantly associated two SNPs with CMA, suggesting that variation in the TLR6 and IL2 genes contribute to the expression of CMA. In addition, since TLR6 and IL2 were earlier associated with other later onset allergies, this also favours the “allergic march” hypothesis. We observed more FLG mutations in the CMA-group, albeit we found no statistical significant enrichment of FLG mutations. Further studies are necessary to investigate the role of common variants and FLG or other skin barrier gene mutations in CMA.

http://link.springer.com/10.1186/s13601-016-0096-9

Source: Clinical and Translational Allergy - March 3, 2016 Category: Allergy & Immunology Source Type: research