The association of IgA deficiency on infection rate, self ‐perceived health, and levels of C‐reactive protein in healthy blood donors
The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self‐reported mental and physical health and the risk of infection in IgA‐deficient blood donors compared to healthy control blood donors. Infectious events, recorded in public health registries either as prescriptions filled of any antimicrobial medicine or as hospital infections, were compared between 177 IgA‐deficient blood donors and 1770 control blood donors. A subset of the IgA‐deficient donors were further characterized by self‐reported health (Short Form‐12, n...
Source: APMIS - February 27, 2018 Category: Research Authors: Sabina Chaudhary Hauge, Charlotte K æstel Jensen, Leif Kofoed Nielsen, Ole B. Pedersen, Erik Sørensen, Lise Wegner Thørner, Henrik Hjalgrim, Christian Erikstrup, Kaspar René Nielsen, Kathrine Agergård Kaspersen, Maria Didriksen, Morten Dziegiel, Henr Tags: Original Article Source Type: research
rpoB gene mutations among Mycobacterium tuberculosis isolates from extrapulmonary sites
This study demonstrated sequence alterations in codon 513 of the 81 bp region of the rpoB gene as the most common mutation occurred in 75.6% of molecularly confirmed rifampin‐resistant strains. In addition, simultaneous mutation at codons 512 and 513 was demonstrated in 34.3% of the isolates. (Source: APMIS)
Source: APMIS - February 27, 2018 Category: Research Authors: Azar Dokht Khosravi, Hossein Meghdadi, Ata A. Ghadiri, Ameneh Alami, Amir Hossein Sina, Mehdi Mirsaeidi Tags: Original Article Source Type: research
Bacterial isolates exhibiting multidrug resistance, hemolytic activity, and high 16S rRNA gene similarity with well ‐known pathogens found in camel milk samples of Riyadh region
Customary consumption of unpasteurized milk by the population in the central Najed region of Saudi Arabia may pose a health risk. Therefore, 80 camel milk samples were collected aseptically from seven different stations of Riyadh region. The biochemical and microbiological properties of these milk samples were determined. Nutrient agar and brain heart infusion agar were used to determine mesophilic aerobic counts (MACs). The MAC in each mL of milk varied from 60 to 16 × 104 CFU/mL on nutrient agar. Based on the colony morphology, 176 colonies were collected from different samples, and these isolates were de‐replicate...
Source: APMIS - February 27, 2018 Category: Research Authors: Abdurahman H. Hirad, Javed Ahmad, Abdulaziz A. Alkhedhairy, Ali H. Bahkali, Shams T. Khan Tags: Original Article Source Type: research
Eosinophilia is a favorable prognostic marker for oral cavity and lip squamous cell carcinoma
Eosinophils are frequently encountered with squamous cell carcinomas (SCC) and it has been proposed that tumor‐associated tissue eosinophilia (TATE) could be of prognostic significance in oral SCC. The aim was to evaluate TATE in 83 oral cavity and 16 lip SCCs as well as the best possible use of TATE as a prognostic marker. The number of eosinophils was counted per high power fields (HPF, ×400) in three different representative areas of the tumor and its stroma. The degree of TATE was analyzed in relation to clinicopathological features of tumors and patients’ survival (follow‐up mean 40.7 months) using Fisher's ex...
Source: APMIS - February 27, 2018 Category: Research Authors: Emma Peurala, Mirella Tuominen, Eliisa L öyttyniemi, Stina Syrjänen, Jaana Rautava Tags: Original Article Source Type: research
Issue Information
(Source: APMIS)
Source: APMIS - February 27, 2018 Category: Research Tags: Issue Information Source Type: research
Expression of 14 ‐3‐3 sigma and eta proteins is unrelated to survival in metastatic high‐grade serous carcinoma
APMIS,Volume 126, Issue 4, Page 309-313, April 2018. (Source: APMIS)
Source: APMIS - February 21, 2018 Category: Research Source Type: research
---
APMIS, Ahead of Print. (Source: APMIS)
Source: APMIS - February 21, 2018 Category: Research Source Type: research
Entrapment of LTB protein in alginate nanoparticles protects against Enterotoxigenic Escherichia coli
APMIS,Volume 126, Issue 4, Page 320-328, April 2018. (Source: APMIS)
Source: APMIS - February 20, 2018 Category: Research Source Type: research
---
APMIS, Ahead of Print. (Source: APMIS)
Source: APMIS - February 20, 2018 Category: Research Source Type: research
---
APMIS,Volume 126, Issue 3, Page 267-272, March 2018. (Source: APMIS)
Source: APMIS - February 7, 2018 Category: Research Source Type: research
---
APMIS,Volume 126, Issue 3, Page 177-185, March 2018. (Source: APMIS)
Source: APMIS - February 5, 2018 Category: Research Source Type: research
---
APMIS,Volume 126, Issue 3, Page 191-200, March 2018. (Source: APMIS)
Source: APMIS - February 4, 2018 Category: Research Source Type: research
Urothelial tumors with villous morphology: Histomorphology and role of immunohistochemistry in diagnosis
Villous adenoma and urothelial carcinoma with villoglandular differentiation (UCVGD) are rare urothelial tumours showing villous morphology, the former being a preneoplastic entity and the latter being a malignant one. The detailed immunohistochemistry of these entities is previously not described in the literature. Moreover, a limited biopsy sample of UCVGD or a villous adenoma with or without adenocarcinoma may be difficult to distinguish on the basis of the histomorphology alone. An immunohistochemical panel comprising of GATA3, p63, β‐catenin, CK7 and CK20 was performed on five cases of UCVGD and three cases of vill...
Source: APMIS - February 4, 2018 Category: Research Authors: Suvradeep Mitra, Debajyoti Chatterjee, Ashim Das, Kirti Gupta, Bishan D. Radotra, Arup K. Mandal Tags: Original Article Source Type: research
Expression of 14 ‐3‐3 sigma and eta proteins is unrelated to survival in metastatic high‐grade serous carcinoma
The objective of this study was to analyze the expression and clinical role of 14‐3‐3 family proteins in high‐grade serous carcinoma (HGSC). Protein expression of 14‐3‐3 sigma (14‐3‐3σ) and 14‐3‐3 eta (14‐3‐3η) by immunohistochemistry was studied in 298 HGSC specimens (249 peritoneal, 49 pleural) and was analyzed for association with clinicopathologic parameters, chemoresponse and survival. The 14‐3‐3σ protein was diffusely (>75% of cells) expressed in 100% of carcinomas in analysis of a pilot series and was therefore not further analyzed. The 14‐3‐3η protein was expressed to a variable...
Source: APMIS - February 1, 2018 Category: Research Authors: Ben Davidson, Arild Holth, Zhihui Wang, Ellen Hellsylt, Claes G. Trop é, Thea E. Hetland Falkenthal, Ruth Holm Tags: Original Article Source Type: research
Entrapment of LTB protein in alginate nanoparticles protects against Enterotoxigenic Escherichia coli
In this study, feasibility of alginate nanoparticles (NPs) such as recombinant LTB from Enterotoxigenic Escherichia coli (ETEC) carrier was investigated. To do this, the eltb gene was cloned and expressed in E. coli BL21 (DE3) host cells, and a Ni‐NTA column purified the protein. NPs were achieved through ion gelation method in the presence of LTB protein and CaCl2 as the cross‐Linker and NPs were characterized physicochemically. Balb/C mice groups were immunized with LTB‐entrapped NPs or LTB with adjuvant and immunogenicity was assessed by evaluating IgG titer. Finally, the neutralization of antibodies was evaluate...
Source: APMIS - February 1, 2018 Category: Research Authors: Emad Kordbacheh, Shahram Nazarian, Abbas Hajizadeh, Davood Sadeghi Tags: Original Article Source Type: research
