Iron uptake and bacteriocin genes among Escherichia coli strains from skin and soft ‐tissue infections
(Source: APMIS)
Source: APMIS - February 23, 2017 Category: Research Authors: Marjanca Star čič Erjavec, Živa Petkovšek, Luka Predojević, Darja Žgur‐Bertok Tags: Letter to the Editor Source Type: research
Development of de novo psoriasis during nivolumab therapy for metastatic renal cell carcinoma: immunohistochemical analyses and clinical outcome
(Source: APMIS)
Source: APMIS - February 23, 2017 Category: Research Authors: Juan Ruiz ‐Bañobre, Ihab Abdulkader, Urbano Anido, Luis León, Rafael López‐López, Jorge García‐González Tags: Letter to the Editor Source Type: research
Immunogenicity and efficacy of a bivalent DNA vaccine containing LeIF and TSA genes against murine cutaneous leishmaniasis
In this study, DNA immunization promoted Th1 immune response characterized by higher IFN‐γ and IgG2a levels and also reduction in lesion size. These results showed that a bivalent vaccine containing two distinct antigens may induce more potent immune responses against leishmaniasis. (Source: APMIS)
Source: APMIS - February 23, 2017 Category: Research Authors: Nahid Maspi, Fatemeh Ghaffarifar, Zohreh Sharifi, Abdolhossein Dalimi, Mohammad Saaid Dayer Tags: Original Article Source Type: research
Transcriptomic and virulence factors analyses of Cryptococcus neoformans hypoxia response
This study investigated the effect of hypoxia on virulence factors (including capsule, melanin, urease, and phospholipase) of C. neoformans and conducted transcriptomic analyses of the virulence‐associated genes. We found that C. neoformans grew under hypoxic condition, albeit slowly, and that hypoxia may have inhibited the capsule size, melanin production, and phospholipase and urease activities in C. neoformans. (Source: APMIS)
Source: APMIS - February 23, 2017 Category: Research Authors: Qingtao Kong, Rui Yang, Zhen Wang, Wenquan Zhou, Xue Du, Suyang Huang, Yuan Jiang, Weida Liu, Hong Sang Tags: Original Article Source Type: research
Different subtypes of epithelioid sarcoma and their clinical implication: long ‐term multi‐institutional experience with a rare sarcoma
Epithelioid sarcoma (ES) is a very rare soft‐tissue sarcoma with a high tendency of recurrence and metastasis. We analyzed clinical features of ES and aimed to identify the potential role of radio‐ and chemotherapy in ES. Fifty‐five patients diagnosed with ES between 1997 and 2014 were enrolled from seven tertiary hospitals in Korean Cancer Research Group. The clinical variables were retrospectively reviewed and analyzed. Forty‐six (84%) patients underwent surgical resection of ES, and among them, 27 experienced recurrence. In these patients, resection margin status and adjuvant radiotherapy were independent progno...
Source: APMIS - February 23, 2017 Category: Research Authors: Chan Kim, Kwai Han Yoo, Min Hwan Kim, Hong Jae Chon, Soon Il Lee, Hyo Jin Lee, Sujin Koh, Ha Yeon Lee, Hye Ran Lee, Kyung Sik Kim, Young Deuk Choi, Sun Young Rha, Su Jin Lee, Hyo Song Kim Tags: Original Article Source Type: research
Expression of erythropoietin and neuroendocrine markers in clear cell renal cell carcinoma
The aim of the study was to investigate the expression of erythropoietin and neuroendocrine markers in clear cell renal cell carcinoma (CCRCC). We retrospectively reviewed the medical records and re‐evaluated histopathological specimens of 33 patients with CCRCC and compared with those of 11 cases of non‐CCRCC. All patients were treated with a partial or radical nephrectomy at St. Olavs Hospital, Trondheim University Hospital, between 2010 and 2016. Thirty‐three patients who were diagnosed with CCRCC had a total of 35 tumours, where 34 of the tumours were CCRCC and one was papillary adenoma. Thirty‐three (97%) of 3...
Source: APMIS - February 23, 2017 Category: Research Authors: Patricia G. Mj ønes, Ivar S. Nordrum, Gunnar Qvigstad, Øystein Sørdal, Liselotte Linnea Mårtensson Rian, Helge L. Waldum Tags: Original Article Source Type: research
Carbonic anhydrase II: a novel biomarker for pseudomyxoma peritonei
This study suggests that the expression of CA II acts as independent prognostic biomarker for survival in PMP. (Source: APMIS)
Source: APMIS - February 23, 2017 Category: Research Authors: Petrus J ärvinen, Antti J. Kivelä, Pirjo Nummela, Anna Lepistö, Ari Ristimäki, Seppo Parkkila Tags: Original Article Source Type: research
Vascular invasion is an adverse prognostic factor in resected non –small‐cell lung cancer
Lung cancer is a leading cause of death, and there is a need for better prognostic factors in treatment decisions. Vascular invasion is a known negative prognosticator, but it is not clear how to evaluate this feature. Here, we studied the prevalence and prognostic impact of blood and lymphatic vascular invasion (BVI, LVI), tumour grade, necrosis, inflammation and pleural invasion on cancer‐specific survival (LCSS) and time to recurrence (TTR) in non–small‐cell lung cancer (NSCLC). A total of 438 patients surgically treated for NSCLC (1993–2010) were examined, including 213 adenocarcinomas (AC), 135 squamous cell c...
Source: APMIS - February 23, 2017 Category: Research Authors: Maria Ramnefjell, Christina Aamelfot, Lars Helgeland, Lars A. Akslen Tags: Original Article Source Type: research
Issue Information
(Source: APMIS)
Source: APMIS - February 23, 2017 Category: Research Tags: Issue Information Source Type: research
Cytopathologic differential diagnosis of low ‐grade urothelial carcinoma and reactive urothelial proliferation in bladder washings: a logistic regression analysis
Conventional cytomorphologic assessment is the first step to establish an accurate diagnosis in urinary cytology. In cytologic preparations, the separation of low‐grade urothelial carcinoma (LGUC) from reactive urothelial proliferation (RUP) can be exceedingly difficult. The bladder washing cytologies of 32 LGUC and 29 RUP were reviewed. The cytologic slides were examined for the presence or absence of the 28 cytologic features. The cytologic criteria showing statistical significance in LGUC were increased numbers of monotonous single (non‐umbrella) cells, three‐dimensional cellular papillary clusters without fibrova...
Source: APMIS - February 21, 2017 Category: Research Authors: Ebru Cakir, Ulku Kucuk, Emel Ebru Pala, Ozlem Sezer, Rahmi Gokhan Ekin, Ozgur Cakmak Tags: Original Article Source Type: research
Association of the IL ‐10 receptor A536G (S138G) loss‐of‐function variant with multiple sclerosis in Tunisian patients
In conclusion, our results suggest that S138G loss‐of‐function polymorphism of the IL‐10R1 may be important risk factor in increasing susceptibility to MS. (Source: APMIS)
Source: APMIS - February 21, 2017 Category: Research Authors: Nadia Ben Fredj, Mouna Aissi, Walid Ben Selma, Imen Mahmoud, Faten Nefzi, Mahbouba Frih ‐Ayed, Jalel Boukadida, Mahjoub Aouni Tags: Original Article Source Type: research
Significant variations in the seroprevalence of C6 ELISA antibodies in a highly endemic area for Lyme borreliosis: evaluation of age, sex and seasonal differences
The purpose of this study was to assess the seroprevalence of C6 ELISA antibodies in healthy blood donors in Kalmar County, Sweden, in relation to age, sex and time of year (peak season vs off season). In addition, we wanted to assess serological status over time in a group of C6 ELISA seropositive blood donors. Sera were collected from 273 (131 women, 142 men) blood donors in autumn 2011 and 300 (144 women, 156 men) in winter 2014. All sera were analysed in the C6 ELISA and the results were interpreted according to the manufacturer′s instructions. The seroprevalence was 22% (females 16%, males 28%) in 2011 and 24% (fema...
Source: APMIS - January 31, 2017 Category: Research Authors: Marcus Johansson, Lena Manfredsson, Annika Wistedt, Lena Serrander, Ivar Tjernberg Tags: Original Article Source Type: research
Monocyte and lymphocyte surface molecules in severe sepsis and non ‐septic critically ill Patients
The aim of the present study was to investigate whether expression of monocyte and lymphocyte surface molecules differs between patients with severe sepsis and non‐septic patients treated in the intensive care unit (ICU). The expression of monocyte CD14, CD40, CD80 and HLA‐DR, and lymphocyte CD69 were analyzed using quantitative flow cytometry on three consecutive days in 27 patients with severe sepsis and in 15 non‐septic patients. Receiver operating characteristic analyses were performed and each corresponding area under the curve (AUC) was determined. The results showed that the expression levels of CD40 on monocy...
Source: APMIS - January 31, 2017 Category: Research Authors: Joel J ämsä, Hannu Syrjälä, Virva Huotari, Eeva‐Riitta Savolainen, Tero Ala‐Kokko Tags: Original Article Source Type: research
Eosinophilia – associated basal plasmacytosis: an early and sensitive histologic feature of inflammatory bowel disease
Basal plasmacytosis is an early‐onset and highly predictive feature of inflammatory bowel disease (IBD), but may have several restrictions in routine histology. Considering evidences about cooperation between eosinophils and plasma cells in IBD pathogenesis, we investigated immunostain of these two cells as a marker of disease. 343 samplings from 83 patients (52 IBD, 31 non‐IBD colitis) were evaluated. The sections were stained with monoclonal antibodies against plasma cells (CD138 and MUM1), and eosinophils (CD193). Eosinophilia‐associated basal plasmacytosis (EBP) was related with the histologic diagnosis of IBD (9...
Source: APMIS - January 25, 2017 Category: Research Authors: Gabriella Canavese, Vincenzo Villanacci, Elisabetta Antonelli, Moris Cadei, Anna Sapino, Rodolfo Rocca, Marco Daperno, Renzo Suriani, Maria Giulia Di santo, Paola Cassoni, Nunzia Bernardini, Gabrio Bassotti Tags: Original Article Source Type: research
The role of toll ‐like and protease‐activated receptors and associated intracellular signaling in Porphyromonas gingivalis‐infected gingival fibroblasts
This study investigates how the expression of protease‐activated receptors (PAR1, PAR2) and toll‐like receptors (TLR2, TLR4) changes with P. gingivalis exposure and how silencing of one receptor affects the expression of the other receptors. The importance of protein kinase C (PKC) and p38 in the regulation of CXCL8 and IL‐6 was also examined. Receptors were knockdown with small‐interfering RNA. PKC or p38 was blocked prior to stimulation with P. gingivalis. Fibroblasts were able to compensate for PAR1 knockdown with increased expression of PAR2. PKC and p38 were involved in the regulation of P. gingivalis‐induce...
Source: APMIS - January 23, 2017 Category: Research Authors: Eleonor Palm, Isak Demirel, Torbj örn Bengtsson, Hazem Khalaf Tags: Original Article Source Type: research
