Coexistence of MACC1 and NM23 ‐H1 dysregulation and tumor budding promise early prognostic evidence for recurrence risk of early‐stage colon cancer
The tumor‐node‐metastasis (TNM) classification, the presence of a mucinous component, and signet ring cells are well‐known criteria for identifying patients at a high risk for recurrence and determining the therapeutic approach for early‐stage colon cancer (eCC). Nevertheless, recurrence can unexpectedly occur in some eCC cases after surgical resection. The aims of the present study were to evaluate the relation of dysregulated MACC1, c‐MET, and NM23‐H1 expression with the histopathological features of tumors in recurrence formation in eCC cases. A total of 100 sporadic eCC patients without poor prognosis facto...
Source: APMIS - January 25, 2018 Category: Research Authors: Ersin Ozturk, Secil AK Aksoy, Nesrin Ugras, Berrin Tunca, Serkan Ceylan, Gulcin Tezcan, Tuncay Yilmazlar, Omer Yerci, Unal Egeli, Gulsah Cecener Tags: Original Article Source Type: research
Issue Information
(Source: APMIS)
Source: APMIS - January 25, 2018 Category: Research Tags: Issue Information Source Type: research
Membrane ‐active peptide PV3 efficiently eradicates multidrug‐resistant Pseudomonas aeruginosa in a mouse model of burn infection
The aim of this study was to evaluate the topical bactericidal activity of peptide PV3 against a MDR isolate of Pseudomonas aeruginosa in a mouse model of burn infection. The structural analysis of PV3 by circular dichroism spectroscopy indicated a low peptide helical content in water, whereas a high helical content was observed in the presence of the more hydrophobic 50% (v/v) trifluoroethanol/water buffer. A confocal microscopy analysis indicated that the main action of PV3 occurred at the membrane of bacteria. Peptide PV3 exhibited superior in vitro anti‐Pseudomonas activity and killing kinetics as compared with dori...
Source: APMIS - January 1, 2018 Category: Research Authors: Hamed Memariani, Delavar Shahbazzadeh, Jean ‐Marc Sabatier, Kamran Pooshang Bagheri Tags: Original Article Source Type: research
Issue Information
(Source: APMIS)
Source: APMIS - December 28, 2017 Category: Research Tags: Issue Information Source Type: research
Placental pathologic lesions with a significant recurrence risk – what not to miss!
APMIS, EarlyView. (Source: APMIS)
Source: APMIS - December 22, 2017 Category: Research Authors: Athena Chen
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Drucilla J. Roberts Source Type: research
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APMIS, Ahead of Print. (Source: APMIS)
Source: APMIS - December 22, 2017 Category: Research Source Type: research
Oseltamivir and indomethacin reduce the oxidative stress in brain and stomach of infected rats
The aim of this study was to determine the effect of oseltamivir and indomethacin on lipid peroxidation (LP), GABA levels, and ATPase activity in brain and stomach of normal and infected rats (IR), as novel inflammation model. Female Sprague Dawley rats grouped five each, either in the absence or presence of a live culture of Salmonella typhimurium (S. typh), were treated as follows: group 1 (control), PBS buffer; group 2, oseltamivir (100 mg/kg); group 3, indomethacin (67 μg/rat); group 4, oseltamivir (100 mg/kg) + indomethacin (67 μg/rat). All drugs were given intraperitoneally for 5 days. IR received the same ...
Source: APMIS - December 21, 2017 Category: Research Authors: David Calder ón Guzmán, Maribel Ortiz Herrera, Norma Osnaya Brizuela, Gerardo Barragán Mejía, Ernestina Hernández García, Hugo Juárez Olguín, Norma Labra Ruíz, Armando Valenzuela Peraza Tags: Original Article Source Type: research
Increased proportions of B cells with spontaneous production of interleukin ‐10 in HIV‐infected individuals are normalized during combination antiretroviral therapy: a longitudinal study
In conclusion, progressors had elevated B10‐cell proportions, while viremic controllers displayed normal proportions. After initiation of cART, the B10‐cell proportion decreased. This could limit B10‐cell‐mediated suppression of specific CD8+ T‐cell responses. (Source: APMIS)
Source: APMIS - December 21, 2017 Category: Research Authors: Camilla Sambleben, Andreas Dehlb æk Knudsen, Hans J. Hartling, Claus H. Nielsen, Susanne D. Nielsen Tags: Original Article Source Type: research
Pseudomesotheliomatous carcinoma of the pleura: an autopsy case of metastasis from a G ‐CSF‐producing anaplastic carcinoma of the pancreas
Pseudomesotheliomatous carcinoma is a malignant tumor that extends along the pleura mimicking malignant mesothelioma. An 81‐year‐old male patient presented to our hospital with epigastralgia, and abdominal computed tomography (CT) showed a 36‐mm tumor in the pancreatic tail. The laboratory data revealed a high leukocyte count (>44 000/μL). Chest CT showed left pleural thickening with pleural effusion. The cancer showed a poor response to chemotherapy, and the patient died of respiratory failure at 5 months after the onset of disease. Autopsy showed solid tumor with hemorrhage, measuring 6 cm in diameter, in the p...
Source: APMIS - December 13, 2017 Category: Research Authors: Yui Hattori, Kazuhiro Sentani, Takuya Hattori, Naohide Oue, Wataru Yasui Tags: Case Report Source Type: research
Macrolide and fluoroquinolone resistance in Mycoplasma genitalium in two Swedish counties, 2011 –2015
Mycoplasma genitalium, causing non‐gonococcal non‐chlamydial urethritis and associated with cervicitis, has developed antimicrobial resistance (AMR) to both the macrolide azithromycin (first‐line treatment) and the fluoroquinolone moxifloxacin (second‐line treatment). Our aim was to estimate the prevalence of resistance, based on genetic AMR determinants, to these antimicrobials in the M. genitalium population in two Swedish counties, Örebro and Halland, 2011–2015. In total, 672 M. genitalium positive urogenital samples were sequenced for 23S rRNA and parC gene mutations associated with macrolide and fluoroquino...
Source: APMIS - December 13, 2017 Category: Research Authors: Ronza Hadad, Daniel Golparian, Amaya C. Lagos, Johan Ljungberg, Peter Nilsson, J örgen S. Jensen, Hans Fredlund, Magnus Unemo Tags: Original Article Source Type: research
Placental pathologic lesions with a significant recurrence risk – what not to miss!
Here, we review three important placental pathologies with significant clinical implications and recurrence risks. They are, in order of most to least frequently seen, villitis of unknown etiology, chronic histiocytic intervillositis, and massive perivillous fibrin deposition (also known as maternal floor infarction). These entities occur in both preterm and term gestations and are observed more frequently with maternal and obstetric disorders including prior pregnancy loss, hypertension/preeclampsia, and autoimmune disease. They are associated with, and probably the cause of, significant perinatal morbidity and mortality ...
Source: APMIS - December 1, 2017 Category: Research Authors: Athena Chen, Drucilla J. Roberts Tags: Review Article Source Type: research
Dynamics of HCV epidemiology in Aydin province of Turkey and the associated factors
This paper gives an update on the local distributions of HCV genotypes in Aydin province of Turkey, provides a comparison with the previous records, and discusses the potential causal reasons shaping the evolving genotype profiles. Patient files from 2011 to 2016 were retrospectively analyzed, and newly detected cases were documented. Out of 286 patients, male and female ratios were determined to remain nearly the same (~50%). Genotype 1 was still the most common (90.2%), followed by genotype 3 (5.9%), genotype 2 (2.1%), and genotype 4 (1.4%) in frequency. There were international patients (4.50%). One patient had genotype...
Source: APMIS - December 1, 2017 Category: Research Authors: Sevin Kirdar, Neriman Aydin, Yasin Tiryaki, Bulent Ertugrul, Adil Coskun, Mehmet Bilgen Tags: Original Article Source Type: research
IFN ‐γ against the 38‐kDa antigen of Mycobacterium tuberculosis discriminates pulmonary tuberculosis from infection and infection from exposure: evidence from a study of human population in a high endemic setting
Mycobacterium tuberculosis (Mtb) 38‐kDa antigen is an immunogenic lipoprotein that induces strong T‐cell responses in experimental animals. However, there is limited information on the role of this antigen in human population. In this article, we present the dynamics of pro‐inflammatory (IFN‐γ and TNF‐α) and anti‐inflammatory cytokine (IL‐10) against the 38 kDa in cohorts of pulmonary TB (PTB) patients, household contacts (HHCs), and community controls (CCs) in a high endemic setting. Whole blood assay was used to determine the levels of cytokines in 149 patients, 149 HHCs, and 68 CCs at baseline, 6 months,...
Source: APMIS - December 1, 2017 Category: Research Authors: Fekadu Abebe, Mulugeta Belay, Mengistu Legesse Tags: Original Article Source Type: research
The genetically determined production of the alarmin eosinophil ‐derived neurotoxin is reduced in visceral leishmaniasis
Visceral leishmaniasis (VL) is the most severe form of leishmaniasis. Recent findings indicate that dendritic cells have a key role in the defense against the Leishmania parasite and that the activity of this cell may be modified by the eosinophil secretory protein eosinophil‐derived neurotoxin (EDN). We hypothesized that the interactions between dendritic cells and EDN might be of importance in the disease development. Cellular content of EDN was analyzed by ELISA. The single‐nucleotide polymorphisms at positions 405, 416, and 1122 in the EDN gene were analyzed by real‐time PCR with TaqMan® reagents. The study coho...
Source: APMIS - November 29, 2017 Category: Research Authors: Kristin Blom, Amir I. Elshafie, Ulla ‐Britt Jönsson, Johan Rönnelid, Lena Douhan Håkansson, Per Venge Tags: Original Article Source Type: research
