Editorial
(Source: APMIS)
Source: APMIS - April 13, 2017 Category: Research Authors: Henrik Calum, Claus Moser Tags: Editorial Source Type: research
Issue Information
(Source: APMIS)
Source: APMIS - April 13, 2017 Category: Research Tags: Issue Information Source Type: research
Chondroid lipoma associated with osteoclast ‐like multinucleated giant cells – a case report
We report case of chondroid lipoma associated with osteoclast‐like multinucleated giant cells. To the best of our knowledge, the presence of these giant cells has not been previously described in the English literature. The recognition of these cells is important and their occurrence in this rare neoplasm should not mislead the pathologist to misdiagnose this entity. (Source: APMIS)
Source: APMIS - April 3, 2017 Category: Research Authors: Mohammed Alyousef, Areej Al Nemer Tags: Case Report Source Type: research
A five ‐miRNA expression signature predicts survival in hepatocellular carcinoma
The aim of this study was to identify a microRNA (miRNA) expression signature for predicting HCC (hepatocellular carcinoma) survival. A total of 322 HCC patients in The Cancer Genome Atlas (TCGA) database were randomly divided into training and testing set. miRNAs, associated with survival time in the training set, were identified by using univariate Cox regression analysis. The risk score was formulated based on the expression levels of these miRNAs. Then the miRNA signature was validated in testing set through Kaplan–Meier analysis and log‐rank test. hsa‐miR‐301a, hsa‐miR‐132, hsa‐miR‐212, hsa‐miR‐489...
Source: APMIS - April 1, 2017 Category: Research Authors: Gang Liu, Hui Wang, Jin ‐dong Fu, Jing‐ying Liu, Ai‐guo Yan, Yan‐yan Guan Tags: Original Article Source Type: research
Erdheim –Chester disease with unusual clinicopathological features complicated by DRESS syndrome, disseminated Cytomegalovirus infection and hemophagocytic lymphohistiocytosis
(Source: APMIS)
Source: APMIS - April 1, 2017 Category: Research Authors: Balan Louis Gaspar, Rakesh Kumar Vasishta, Reena Das, Ashish Bhalla Tags: Letter to the Editor Source Type: research
Citrate attenuates vascular calcification in chronic renal failure rats
In conclusion, citrate may attenuate vascular calcification in adenine‐induced CRF rats. (Source: APMIS)
Source: APMIS - March 23, 2017 Category: Research Authors: Yan Ou, Zengying Liu, Shuiqin Li, Xiaojing Zhu, Yan Lin, Jin Han, Zhaoyang Duan, Lining Jia, Baosong Gui Tags: Original Article Source Type: research
Tumor necrosis factor ‐α −308G/A and −238G/A polymorphisms are associated with increased risks of sepsis: evidence from an updated meta‐analysis
Previous studies have reported the relationship between tumor necrosis factor‐α (TNF‐α) −308G/A and −238G/A polymorphisms and sepsis risk with inconsistent results. The aim of this study was to estimate the association of the two polymorphisms with risk of sepsis or sepsis‐related mortality using a meta‐analysis. PubMed, Embase, and Web of Science databases were searched up to June 20 2016. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed or random effect model. Twenty‐six studies were included in this meta‐analysis. Overall, an increased sepsis risk of TNF‐α −3...
Source: APMIS - March 14, 2017 Category: Research Authors: Mu Zhang, Yu Zhao, Qiong Liu Tags: Original Article Source Type: research
The prevalence of HPV infections in HPV ‐vaccinated women from the general population
Currently, three prophylactic HPV vaccines are commercially available to prevent HPV 16/18 infection and associated lesions. The aim of the study was to assess markers of HPV infection in women/girls before vaccination and to ascertain the prevalence and spectrum of post‐vaccination HPV types. Three hundred and thirty subjects of which 75 were virgins were enrolled. Before the first dose of the HPV vaccine and 1, 3 and 5 years after the completion of HPV vaccination, the samples for cytology, HPV detection and anti‐HPV antibody response were taken. At enrolment, HPV DNA was detected in 38% of sexually active girls/wome...
Source: APMIS - March 14, 2017 Category: Research Authors: Eva Hamsikova, Jana Smahelova, Viera Ludvikova, Martina Salakova, Jana Rychla, Jana Skrenkova, Lukas Rob, Ruth Tachezy Tags: Original Article Source Type: research
Dissemination of metallo ‐β‐lactamase in Pseudomonas aeruginosa isolates in Egypt: mutation in blaVIM‐4
This study was designed to investigate the prevalence of metallo‐β‐lactamase (MBL) in Pseudomonas aeruginosa isolates collected from Suez Canal University Hospital in Ismailia, Egypt. Antibiotic susceptibility testing and phenotypic and genotypic screening for MBLs were performed on 147 isolates of P. aeruginosa. MICs were determined by agar dilution method for carbapenem that was ≥2 μg/mL for meropenem. MBL genes were detected by multiplex and monoplex PCR for P. aeruginosa‐harbored plasmids. Mutation profile of sequenced MBL genes was screened using online software Clustal Omega. Out of 147 P. aeruginosa, 39 (2...
Source: APMIS - March 14, 2017 Category: Research Authors: Hany Hashem, Amro Hanora, Salah Abdalla, Alaa Shaeky, Alaa Saad Tags: Original Article Source Type: research
Carbapenemases ‐producing Klebsiella pneumoniae in hospitals of two regions of Southern Italy
This study was aimed at characterizing by phenotypic and genotypic methods carbapenem‐resistant K. pneumoniae isolated from several Hospitals of Apulia and Basilicata, Southern Italy. Antibiotic susceptibility was also evaluated. The relatedness of carbapenemase‐producing K. pneumoniae strains was established by pulsed‐field gel electrophoresis (PFGE). Among the 150 K. pneumoniae carbapenemase producers, KPC‐3 genotype was the most predominant (95%), followed by VIM‐1 (5%). No other genotypes were found and no co‐presence of two carbapenemase genes was found. A full concordance between results obtained by b...
Source: APMIS - March 14, 2017 Category: Research Authors: Carla Calia, Carlo Pazzani, Marta Oliva, Maria Scrascia, Piero Lovreglio, Carmen Capolongo, Anna Maria Dionisi, Adriana Chiarelli, Rosa Monno Tags: Original Article Source Type: research
CYP1A1m1 and CYP2C9*2 and *3 polymorphism and risk to develop ARV ‐associated hepatotoxicity and its severity
In conclusion, individuals with CYP1A1m13801CC and 3801TC genotypes independently and in the presence of alcohol and nevirapine usage is likely to be associated with increased risk of development of ARV‐associated hepatotoxicity, its severity, and advancement of disease. CYP2C9*31075AC genotype with combined alcohol and nevirapine usage indicated a risk for development of ARV‐associated hepatotoxicity. (Source: APMIS)
Source: APMIS - March 1, 2017 Category: Research Authors: HariOm Singh, Sonam Lata, Vijay Nema, Dharmesh Samani, Manisha Ghate, Raman R. Gangakhedkar Tags: Original Article Source Type: research
Apoptotic pathways of macrophages within osteolytic interface membrane in periprosthestic osteolysis after total hip replacement
The objective of this study was to identify the apoptotic mechanism of macrophages, and to explore the relationship between the apoptotic pathways and progression of osteolysis. Transmission electron microscopy (TEM) was utilized to analyze the tissue ultrastructure of wear particles, and in situ apoptotic macrophage identification was performed by TUNEL staining. We analyzed the expression of the key biomarkers of apoptotic pathways via immunohistochemistry and Western blotting. Our results demonstrated that the majority of wear particles within osteolytic interface membrane was in the 30–60 nm range, and that macrophag...
Source: APMIS - March 1, 2017 Category: Research Authors: Guoyin Liu, Ting Guo, Yong Zhang, Naicheng Liu, Jiangning Chen, Jianmin Chen, Junfeng Zhang, Jianning Zhao Tags: Original Article Source Type: research
Toll ‐like receptor‐2 Arg753Gln and Arg677Trp polymorphisms and susceptibility to pulmonary and peritoneal tuberculosis
Recent evidence suggests that toll‐like receptor‐2 (TLR2) is important for host defense against Mycobacterium tuberculosis (MTB). TLR2 polymorphisms have shown significant impact on susceptibility or resistance to tuberculosis (TB). This case–control study aims to determine the influence of TLR2 (Arg753Gln and Arg677Trp) polymorphisms on the susceptibility to develop pulmonary or peritoneal TB. Genotyping of TLR2 (Arg753Gln and Arg677Trp) polymorphisms was carried out on 52 patients with pulmonary TB, 44 patients with peritoneal TB, and 50 healthy controls using polymerase chain reaction‐restriction fragment length...
Source: APMIS - March 1, 2017 Category: Research Authors: Mohammed A. Saleh, Mahmoud M. Ramadan, Eman O. Arram Tags: Original Article Source Type: research
Evaluation of phytochemicals from medicinal plants of Myrtaceae family on virulence factor production by Pseudomonas aeruginosa
Virulence factors regulated by quorum sensing (QS) play a critical role in the pathogenesis of an opportunistic human pathogen, Pseudomonas aeruginosa in causing infections to the host. Hence, in the present work, the anti‐virulence potential of the medicinal plant extracts and their derived phytochemicals from Myrtaceae family was evaluated against P. aeruginosa. In the preliminary screening of the tested medicinal plant extracts, Syzygium jambos and Syzygium antisepticum demonstrated a maximum inhibition in QS‐dependent violacein pigment production by Chromobacterium violaceum DMST 21761. These extracts demonstrated ...
Source: APMIS - February 28, 2017 Category: Research Authors: Khadar Syed Musthafa, Wipawadee Sianglum, Jongkon Saising, Sakkarin Lethongkam, Supayang Piyawan Voravuthikunchai Tags: Original Article Source Type: research
Circulating syndecans during critical illness
Circulating syndecans are proposed to be markers of glycocalyx degradation and previous investigations have found higher plasma levels of syndecan‐1 among patients with different pathological conditions. We wanted to investigate if levels of other syndecans (‐2,‐3 and ‐4) are altered during critical illness and compare the levels to syndecan‐1. In 137 consecutive intensive care unit (ICU) patients with sepsis, cardiac arrest, gastrointestinal bleeding, intoxication or trauma, plasma levels of syndecan‐1, ‐2, ‐3 and ‐4 were measured using ELISA. Syndecan‐1 and syndecan‐3 levels were similar among the d...
Source: APMIS - February 28, 2017 Category: Research Authors: Axel Nelson, Joakim Johansson, Jonas Tyd én, Mikael Bodelsson Tags: Original Article Source Type: research
