CYP1A1m1 and CYP2C9*2 and *3 polymorphism and risk to develop ARV ‐associated hepatotoxicity and its severity

In conclusion, individuals with CYP1A1m13801CC and 3801TC genotypes independently and in the presence of alcohol and nevirapine usage is likely to be associated with increased risk of development of ARV‐associated hepatotoxicity, its severity, and advancement of disease. CYP2C9*31075AC genotype with combined alcohol and nevirapine usage indicated a risk for development of ARV‐associated hepatotoxicity.
Source: APMIS - Category: Research Authors: Tags: Original Article Source Type: research