Paratesticular seminoma: echographic features and histological diagnosis with review of the literature
We report the 4th primary seminoma of the paratesticular region/spermatic cord in a 35‐year‐old man, including the first echographic description. We provide review of the literature and etiopathogenetic discussion. Ultrasound examination showed a right paratesticular, solid, heterogeneous mass (iso‐hypoechoic with hyperechoic striae; peri‐ and intra‐lesional vascular signals) with no testicular involvement: the paratesticular origin was confirmed by pathological examination. Despite careful gross examination and extensive sampling, the 6.5‐cm extratesticular tumor revealed only one microscopic focus with minima...
Source: APMIS - February 1, 2018 Category: Research Authors: Andrea Palicelli, Pierluigi Neri, Giansilvio Marchioro, Paolo De Angelis, Gianmarco Bondonno, Antonio Ramponi Tags: Case Report Source Type: research
Extracellular proteases of Staphylococcus epidermidis: roles as virulence factors and their participation in biofilm
The objective of this work is to provide an overview of the current knowledge of S. epidermidis’ extracellular proteases during pathogenicity, especially in the different stages of biofilm formation. (Source: APMIS)
Source: APMIS - February 1, 2018 Category: Research Authors: Sergio Mart ínez‐García, Sandra Rodríguez‐Martínez, Mario E. Cancino‐Diaz, Juan C. Cancino‐Diaz Tags: Review Article Source Type: research
Serum intestinal fatty acid –binding protein in the noninvasive diagnosis of celiac disease
Current diagnostic guidelines for celiac disease (CD) in pediatric patients require a duodenal biopsy if the IgA anti‐tissue transglutaminase (tTG) is below 10x the upper limit of normal (ULN). Additional markers may enable a noninvasive diagnosis in this group. Serum intestinal‐fatty acid‐binding protein (I‐FABP), a marker for intestinal epithelial damage, could be useful in this respect. A total of 95 children with a clinical suspicion of CD and tTG 1‐10x ULN were investigated. All had a duodenal biopsy and analysis of serum I‐FABP. A control group of 161 children with familial short stature and normal tTG wa...
Source: APMIS - January 31, 2018 Category: Research Authors: Irene B. Oldenburger, Victorien M. Wolters, Tineke Kardol ‐Hoefnagel, Roderick H. J. Houwen, Henny G. Otten Tags: Original Article Source Type: research
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APMIS,Volume 126, Issue 3, Page 186-190, March 2018. (Source: APMIS)
Source: APMIS - January 31, 2018 Category: Research Source Type: research
Deregulation of microRNA ‐155 and its transcription factor NF‐kB by polychlorinated biphenyls during viral infections
Polychlorinated biphenyls (PCBs), and similar environmental contaminants, have been linked to virus outbreaks and increased viral induced mortality since the 1970s. Yet the mechanisms behind this increased susceptibility remain elusive. It has recently been illustrated that the innate immune viral detection system is tightly regulated by small non‐coding RNAs, including microRNAs (miRNAs). For virus infections miRNA‐155 expression is an important host response against infection, and deregulation of this miRNA is closely associated with adverse outcomes. Thus, we designed a targeted in vitro study using primary chicken ...
Source: APMIS - January 30, 2018 Category: Research Authors: Courtney A. Waugh, Augustine Arukwe, Veerle L. B. Jaspers Tags: Original Article Source Type: research
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APMIS,Volume 126, Issue 3, Page 234-240, March 2018. (Source: APMIS)
Source: APMIS - January 30, 2018 Category: Research Source Type: research
Histopathological evaluation of duodenal biopsy in the PreventCD project. An observational interobserver agreement study
Aim of the current study was to evaluate the inter‐observer agreement between pathologists in the diagnosis of celiac disease (CD), in the qualified context of a multicenter study. Biopsies from the “PreventCD” study, a multinational‐ prospective‐ randomized study in children with at least one‐first‐degree relative with CD and positive for HLA‐DQ2/HLA‐DQ8. Ninety‐eight biopsies were evaluated. Considering diagnostic samples with villous atrophy (VA), the agreement was satisfactory (κ = 0.84), but much less when assessing the severity of these lesions. The use of the recently proposed Corazza‐Villanac...
Source: APMIS - January 26, 2018 Category: Research Authors: Vincenzo Villanacci, Luisa Lorenzi, Francesco Donato, Renata Auricchio, Piotr Dziechciarz, Judit Gyimesi, Sibylle Koletzko, Zrinjka Mi šak, Vanesa Morente Laguna, Isabel Polanco, David Ramos, Raanan Shamir, Riccardo Troncone, Sabine L. Vriezinga, M. Luis Tags: Original Article Source Type: research
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APMIS,Volume 126, Issue 3, Page 208-214, March 2018. (Source: APMIS)
Source: APMIS - January 26, 2018 Category: Research Source Type: research
Distribution of Ebp pili among clinical and fecal isolates of Enterococcus faecalis and evaluation for human platelet activation
APMIS,Volume 126, Issue 4, Page 314-319, April 2018. (Source: APMIS)
Source: APMIS - January 25, 2018 Category: Research Source Type: research
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APMIS, Ahead of Print. (Source: APMIS)
Source: APMIS - January 25, 2018 Category: Research Source Type: research
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APMIS,Volume 126, Issue 3, Page 227-233, March 2018. (Source: APMIS)
Source: APMIS - January 25, 2018 Category: Research Source Type: research
Distribution of Ebp pili among clinical and fecal isolates of Enterococcus faecalis and evaluation for human platelet activation
Although Enterococcus faecalis is known as normal flora in colon, it is also amongst the most common causative agents of infective endocarditis (IE). Platelet activation resulting from adherence to platelets is an essential step in the pathogenesis of IE. One of the factors proposed in adhesion is endocarditis‐ and biofilm‐ associated pili encoded by ebp operon. The aim of this study was to investigate ebp in isolates from different origins and analyze the potential of isolates to activate human platelets of different donors. The ebp distribution was investigated in E. faecalis from different origin infections (n = 103...
Source: APMIS - January 25, 2018 Category: Research Authors: Roya Ahmadrajabi, Mohammad Sadegh Dalfardi, Alireza Farsinejad, Fereshteh Saffari Tags: Original Article Source Type: research
The association of interferon ‐gamma, interleukin‐4 and interleukin‐17 single‐nucleotide polymorphisms with susceptibility to tuberculosis
In conclusion, single‐nucleotide mutations in different cytokine genes may have protective effects or increase the risk of tuberculosis. (Source: APMIS)
Source: APMIS - January 25, 2018 Category: Research Authors: Fatemeh Mansouri, Rasoul Heydarzadeh, Saber Yousefi Tags: Original Article Source Type: research
Native aortic endocarditis due to an unusual pathogen: Actinotignum schaalii
We report a case of aortic native valve endocarditis due to Actinotignum schaalii in an 89‐year‐old man with prostatism history but no signs of urinary infection. Actinotignum schaalii was isolated not only from positive blood culture but also from cardiac valve culture using mass spectrometry and 16S rDNA sequencing. Actinotignum schaalii is recognized as commensal of genitourinary tract, but it was underdiagnosed. The advances in bacterial identification such as MALDI‐TOF MS probably explain the increasing described cases of infections due to A. schaalii these last years. (Source: APMIS)
Source: APMIS - January 25, 2018 Category: Research Authors: Caroline Lo ïez, Rosario Pilato, Adeline Mambie, Sylvie Hendricx, Karine Faure, Frédéric Wallet Tags: Case Report Source Type: research
Alarmins as biomarkers of gastrointestinal surgical injury – a pilot study
The dysregulation of inflammatory response to surgical injury affects outcomes. Alarmins, the earliest bioactive substances from damaged cells, play a crucial role in initiating the inflammation. We analyzed serum levels of alarmins (S100A8, S100A12, high mobility group box, and heat shock protein 70) after major abdominal surgery (MAS) in surgical (S) (n = 82) and nonsurgical (NS) groups (n = 35). The main objective was determining a role of selected alarmins in host response to MAS. The secondary objectives were (i) evaluation of the relationship among alarmins and selected biomarkers (C‐reactive protein, interleuk...
Source: APMIS - January 25, 2018 Category: Research Authors: Jan Maca, Michal Holub, Filip Bursa, Peter Ihnat, Petr Reimer, Zdenek Svagera, Michal Burda, Pavel Sevcik Tags: Original Article Source Type: research
