Heading for centennial anniversary and beyond
(Source: APMIS)
Source: APMIS - November 29, 2017 Category: Research Tags: Editorial Source Type: research
In Memoriam Ben Vainer 18.6.1969 –21.6.2017
(Source: APMIS)
Source: APMIS - November 29, 2017 Category: Research Tags: Obituary Source Type: research
Issue Information
(Source: APMIS)
Source: APMIS - November 29, 2017 Category: Research Tags: Issue Information Source Type: research
Fibrin thrombi in deceased donor kidneys: Prevalence and influence on graft function and graft survival in transplanted patients
In conclusion, FT in donor kidney biopsies at time of transplantation is a risk factor for the development of reduced renal function during the first year of transplantation. (Source: APMIS)
Source: APMIS - November 20, 2017 Category: Research Authors: Ditte Hansen, Sara R ørvig, Claus B. Andersen, Søren S. Sørensen Tags: Original Article Source Type: research
The value of microscopic ‐observation drug susceptibility assay in the diagnosis of tuberculosis and detection of multidrug resistance
In conclusion, MODS is an inexpensive and rapid test with good performance characteristics for direct diagnosis of tuberculosis and detection of multidrug resistance. (Source: APMIS)
Source: APMIS - November 20, 2017 Category: Research Authors: Den İz Sertel Şelale, Meltem Uzun Tags: Original Article Source Type: research
Impact of heat shock protein 60KD in combination with outer membrane proteins on immune response against Brucella melitensis
Brucellosis caused by the bacterium Brucella affects various domestic and wild species. The outer membrane proteins 25 and 31 play key roles on stimulation of cell‐mediated immune response against Brucella. GroEL as one of the major Brucella antigens stimulates the immune system and increases intracellular survival of bacteria. In the present study, we assumed injection of GroEL in combination with OMP25 and OMP31 would offer higher immunity levels. So, the impact of GroEL with different concentrations of recombinant outer membrane proteins emulsified in Chitosan Nanoparticles on immune responses was evaluated in mice mo...
Source: APMIS - November 20, 2017 Category: Research Authors: Tooba Abbassi ‐Daloii, Soheil Yousefi, Mohammad Hadi Sekhavati, Mojtaba Tahmoorespur Tags: Original Article Source Type: research
Transmission electron microscopy helpfulness in Whipple's disease masked by immunosuppressant therapy for arthritis
A 61‐year‐old woman received a diagnosis of undifferentiated non‐erosive arthritis in 2010 and assumed methotrexate and steroids in 2014. After 1 year, she experienced watery diarrhea, vomiting, fever, weight loss, and severe hypoalbuminemia, thus being admitted into our Unit. Esophagogastroduodenoscopy showed duodenal lymphangiectasia and duodenal biopsy samples several foamy PAS‐positive macrophages and villous subtotal atrophy. Transmission electron microscope demonstrated several extracellular and intracellular rod‐shaped bacteria (Tropheryma whipplei). Therefore, we diagnosed Whipple's disease. Our patient a...
Source: APMIS - November 20, 2017 Category: Research Authors: Alessandra Loiodice, Giuseppe Losurdo, Andrea Iannone, Roberta Rossi, Maria Grazia Fiore, Domenico Piscitelli Tags: Case Report Source Type: research
In vitro activity and time ‐kill curve analysis of sitafloxacin against a global panel of antimicrobial‐resistant and multidrug‐resistant Neisseria gonorrhoeae isolates
Treatment of gonorrhoea is a challenge worldwide because of emergence of resistance in N. gonorrhoeae to all therapeutic antimicrobials available and novel antimicrobials are imperative. The newer‐generation fluoroquinolone sitafloxacin, mostly used for respiratory tract infections in Japan, can have a high in vitro activity against gonococci. However, only a limited number of recent antimicrobial‐resistant isolates from Japan have been examined. We investigated the sitafloxacin activity against a global gonococcal panel (250 isolates cultured in 1991–2013), including multidrug‐resistant geographically, temporally ...
Source: APMIS - November 20, 2017 Category: Research Authors: Agnez J önsson, Sunniva Foerster, Daniel Golparian, Ryoichi Hamasuna, Susanne Jacobsson, Magnus Lindberg, Jörgen Skov Jensen, Makoto Ohnishi, Magnus Unemo Tags: Original Article Source Type: research
Napsin A and WT 1 are useful immunohistochemical markers for differentiating clear cell carcinoma ovary from high ‐grade serous carcinoma
Clear cell carcinoma (CCC) of the ovary is an uncommon, but an aggressive epithelial ovarian cancer (EOC), which has overlapping histopathologic features with other ovarian tumours. Lately, Napsin A has been identified as its useful diagnostic immunohistochemical (IHC) marker. Fifty‐eight prospectively diagnosed ovarian CCCs, 53 high‐grade serous carcinomas (HGSCs), 16 endometrioid adenocarcinomas (EMACs), six mixed carcinomas, containing components of CCC and EMAC, seven metastatic mucinous adenocarcinomas and six ovarian yolk sac tumours (YSTs) were tested for Napsin A immunostaining. Fifty ovarian CCCs, 50 HGSCs, se...
Source: APMIS - November 20, 2017 Category: Research Authors: Bharat Rekhi, Kedar K. Deodhar, Santosh Menon, Amita Maheshwari, Jyoti Bajpai, Jaya Ghosh, Surappa Thumkur Shylasree, Sudeep Gupta Tags: Original Article Source Type: research
Localization of surfactant protein ‐D in the rheumatoid synovial membrane
Surfactant protein‐D (SP‐D) is a collectin, which plays an important role in airway protection and inflammation. The molecule has both pro‐ and anti‐inflammatory capacities depending on its molecular size. Its involvement in joint diseases is largely unknown and the aim of this investigation was to study SP‐D occurrence and distribution in the synovial membrane of patients with long‐standing rheumatoid arthritis (RA) and osteoarthritis (OA). Six RA patients and six OA patients, who underwent total hip arthroplasty, were included in the study. Synovial tissue biopsies were obtained during surgery and subsequentl...
Source: APMIS - November 20, 2017 Category: Research Authors: Anne Friesgaard Christensen, Grith Lykke Sorensen, Kirsten Junker, Peter Hvidbak Revald, Claus Varnum, Flemming Brandt Sorensen, Peter Junker Tags: Original Article Source Type: research
Relationship between hepatic progenitor cells and stellate cells in chronic hepatitis C genotype 4
Hepatitis C virus (HCV) infection represents a major health problem in many areas of the world, especially Egypt. Hepatic progenitor cells (HPCs) and hepatic stellate cells (HSCs) have been implicated in fibrosis progression in chronic HCV. The aim of this study was to investigate the role of HPCs and HSCs in chronic HCV infection and the relationship between both cell types. This retrospective study was conducted on 100 chronic HCV patients. Immunohistochemistry was performed on liver tissue sections for cytokeratin 19 (progenitor cell markers), smooth muscle actin (stellate cell markers), matrix metalloproteinase‐9 (MM...
Source: APMIS - November 20, 2017 Category: Research Authors: Thanaa El Sayed Ahmed Helal, Nermine Ahmed Ehsan, Nehal Ahmed Radwan, Eman Abdelsameea Tags: Original Article Source Type: research
The modulatory role of cytokines IL ‐4 and IL‐17 in the functional activity of phagocytes in diabetic pregnant women
The study investigated the role of cytokines IL‐4 and IL‐17 in the modulation of the functional activity of mononuclear phagocytes in diabetic pregnant women with hyperglycemia. Sixty pregnant women were assigned to the following groups: nondiabetic (ND), mild gestational hyperglycemia (MGH), gestational diabetes mellitus (GDM), or type 2 diabetes mellitus (DM2). The functional activity of phagocytes from maternal blood, cord blood, and colostrum was assessed by determining their superoxide release, phagocytosis, microbicidal activity, and intracellular Ca2+ release. Irrespective of glycemic status, colostrum and blood...
Source: APMIS - November 14, 2017 Category: Research Authors: Danny L. G. Fagundes, Eduardo L. Fran ça, Michelangelo B. Gonzatti, Marilza V. C. Rugde, Iracema M. P. Calderon, Adenilda C. Honorio‐França Tags: Original Article Source Type: research
Erysipelothrix rhusiopathiae serotype 5 ‐associated metritis in a Norwegian Red heifer
This report summarized the findings of a case of Erysipelothrix rhusiopathiae infection in a farmed Norwegian Red heifer located in the south‐east of Norway. The 2.5‐year‐old pregnant heifer was found dead after a short episode of inappetence. On gross exam, the heifer was severely dehydrated with uterine torsion. Microscopically, necrosis of the endometrium was present throughout the uterus along with presence of intralesional Gram‐positive bacteria, interstitial nephritis, and pyelonephritis. E. rhusiopathiae was isolated from the uterus and placenta and was also demonstrated by immunohistochemistry (IHC) in the ...
Source: APMIS - November 1, 2017 Category: Research Authors: Øyvor Kolbjørnsen, Bjarne Bergsjø, Jeanette Sveen, Tanja Opriessnig Tags: Case Report Source Type: research
Association of Helicobacter pylori infection with Toll ‐like receptor‐4 Thr399Ile polymorphism increased the risk of peptic ulcer development in North of Iran
This study aimed to investigate whether TLR4 polymorphisms are associated with H. pylori susceptibility and risk of peptic ulcer development or not. The TLR4 + 3725 G/C polymorphism was studied using polymerase chain reaction with confronting two‐pair primers (PCR–CTPP). In addition, TLR4 Asp299Gly and Thr399Ile polymorphisms were evaluated by PCR‐restriction fragment length polymorphism (RFLP). There was no significant difference in TLR4 + 3725 G/C and Asp299Gly genotype frequencies between non‐peptic ulcer (NPUD) and peptic ulcer (PUD) individuals in the context of peptic ulcer development and susceptibili...
Source: APMIS - November 1, 2017 Category: Research Authors: Mehdi Tourani, Maryam Habibzadeh, Javad Shokri ‐Shirvani, Omid Teymournejad, Amrollah Mostafazadeh, Soraya Khafri, Hamid Reza Nouri Tags: Original Article Source Type: research
Primary antibiotic resistance of Helicobacter pylori strains among adults and children in a tertiary referral centre in Lithuania
The study evaluated primary antibiotic resistance of Helicobacter pylori within the period 2013–2015 and trends of antibiotic consumption over the last decade in Lithuania; 242 adults and 55 children were included in the study. E‐tests were performed for amoxicillin, metronidazole, clarithromycin, ciprofloxacin, rifampicin and tetracycline. The presence of H. pylori and clarithromycin resistance was additionally tested by PCR. Helicobacter pylori culture was positive in 67 of 242 (28%) adult and in 12 of 55 (21.8%) children samples. Resistance rates among adults by E‐tests were as follows: metronidazole – 32.8% (95...
Source: APMIS - November 1, 2017 Category: Research Authors: Gintare Dargiene, Juozas Kupcinskas, Laimas Jonaitis, Mindaugas Vezbavicius, Edmundas Kadusevicius, Eugenija Kupcinskiene, Tove Havnhoj Frandsen, Ruta Kucinskiene, Limas Kupcinskas, Leif Percival Andersen Tags: Original Article Source Type: research
