Immunogenicity and efficacy of a bivalent DNA vaccine containing LeIF and TSA genes against murine cutaneous leishmaniasis

In this study, DNA immunization promoted Th1 immune response characterized by higher IFN‐γ and IgG2a levels and also reduction in lesion size. These results showed that a bivalent vaccine containing two distinct antigens may induce more potent immune responses against leishmaniasis.

Source: APMIS - February 23, 2017 Category: Research Authors: Nahid Maspi, Fatemeh Ghaffarifar, Zohreh Sharifi, Abdolhossein Dalimi, Mohammad Saaid Dayer Tags: Original Article Source Type: research