Transcriptomic and virulence factors analyses of Cryptococcus neoformans hypoxia response

This study investigated the effect of hypoxia on virulence factors (including capsule, melanin, urease, and phospholipase) of C. neoformans and conducted transcriptomic analyses of the virulence‐associated genes. We found that C. neoformans grew under hypoxic condition, albeit slowly, and that hypoxia may have inhibited the capsule size, melanin production, and phospholipase and urease activities in C. neoformans.

Source: APMIS - February 23, 2017 Category: Research Authors: Qingtao Kong, Rui Yang, Zhen Wang, Wenquan Zhou, Xue Du, Suyang Huang, Yuan Jiang, Weida Liu, Hong Sang Tags: Original Article Source Type: research