Cz ęść II: Wytyczne postępowania w hemofilii A i B powikłanej inhibitorem czynnika VIII i IX (2 wydanie)
Publication date: Available online 8 August 2017 Source:Acta Haematologica Polonica Author(s): Jerzy Windyga, Krzysztof Chojnowski, Anna Klukowska, Magdalena Łętowska, Andrzej Mital, Wojciech Młynarski, Jacek Musiał, Jarosław Peregud-Pogorzelski, Maria Podolak-Dawidziak, Jacek Treliński, Anetta Undas, Tomasz Urasiński, Joanna Zdziarska, Krystyna Zawilska In this article, the Working Group for Haemostasis of the Polish Society of Haematology and Blood Transfusion updates the principles of diagnosis and treatment of haemophilia A and B complicated by factor VIII or IX inhibitors, which were published f...
Source: Acta Haematologica Polonica - August 8, 2017 Category: Hematology Source Type: research
Methods for detection of microparticles derived from blood and endothelial cells
Publication date: Available online 5 August 2017 Source:Acta Haematologica Polonica Author(s): Małgorzata Gradziuk, Piotr Radziwon (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - August 5, 2017 Category: Hematology Source Type: research
Aloplasty of an ankylosed knee in a patient with severe haemophilia A
Publication date: Available online 29 July 2017 Source:Acta Haematologica Polonica Author(s): Jerzy Mirosław Jaworski, Adam Zawojski, Joanna Zdziarska, Krzysztof Czernicki, Magdalena Wilk-Frańczuk The goal of this report is to describe a case of knee arthroplasty in a patient with over a 20 year long history of ankylosis of the left knee joint in the course of severe haemophilia A. Clinical and functional conditions were assessed by means of a Knee Society Score (KSS); pain intensity by Visual Analogue Scale (VAS); and intensity of degeneration of bone forming the joint by means of the Kellgren-Lawrence Scale. ROM...
Source: Acta Haematologica Polonica - July 29, 2017 Category: Hematology Source Type: research
Zmiany w badaniach kontroli jako ści składników krwi w Polsce
Conclusions The implementation of modern techniques/methods of blood component preparation as well as staff training at regular intervals contributed to higher percentage of blood components that meet quality control criteria. The periodical reduction in the number of PCs meeting minimum quality control criteria was most likely due to higher demand for this type of blood component and thus higher frequency of using split apheresis PCs. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - July 29, 2017 Category: Hematology Source Type: research
Zastosowanie cytometrii przep ływowej w badaniach immunohematologicznych krwinek czerwonych
Publication date: Available online 27 July 2017 Source:Acta Haematologica Polonica Author(s): Jadwiga Fabijańska-Mitek, Anna Stachurska Flow cytometry (FC) has been primarily applied to the diagnosis of hematological malignancies, and thereafter, to detection and quantification of CD34+ cells in bone marrow transplants, and granulocytes in neutropenias and paroxysmal nocturnal hemoglobinuria (PNH). In PNH and hereditary spherocytosis, changes in some of the erythrocyte membrane proteins are tested (CD59, CD55, and band 3). The purpose of this paper is to focus on the use of FC in RBC testing. With anti-D, -HbF, and -C...
Source: Acta Haematologica Polonica - July 28, 2017 Category: Hematology Source Type: research
Nietypowe objawy kliniczne szpiczaka plazmocytowego
Publication date: Available online 27 July 2017 Source:Acta Haematologica Polonica Author(s): Artur Jurczyszyn, Magdalena Olszewska-Szopa Multiple myeloma accounting for 10% of malignancies of haematopoietic system is a heterogenous disease. In the era of individual approach to the patient, we are more and more interested in distinct features and forms of this malignancy. In the article, we described rare MM manifestations with reference to location (central nervous system and skin), M-protein produced by the tumor cells (biclonal and immunoglobulin M), early onset of the disease (young versus old) and pregnancy in MM ...
Source: Acta Haematologica Polonica - July 28, 2017 Category: Hematology Source Type: research
Jak rozpoznawa ć i leczyć chorobę Gauchera: zarys patofizjologii, objawów klinicznych, metod diagnostycznych i leczenia
Publication date: Available online 24 July 2017 Source:Acta Haematologica Polonica Author(s): Egle Sumskiene, Maciej Machaczka Rare diseases are a diagnostic challenge for modern medicine. Gaucher disease is a rare autosomal recessive lipid storage disorder caused by the deficient activity of the lysosomal enzyme glucocerebrosidase. In the absence of known affected family member, frequent symptoms of Gaucher disease, such as thrombocytopenia or splenomegaly, often lead to hematological diagnostic workup. This review highlights pathophysiology, signs and symptoms, diagnostic and therapeutic principles of Gaucher disease...
Source: Acta Haematologica Polonica - July 25, 2017 Category: Hematology Source Type: research
Ryzyko przeniesienia czynnik ów zakaźnych przez transfuzje w Polsce
Publication date: Available online 24 July 2017 Source:Acta Haematologica Polonica Author(s): Piotr Grabarczyk, Aneta Kopacz, Ewa Sulkowska, Aleksandra Kalińska Blood transfusion in Poland is the safest in history. High virological level of safety has been achieved mainly by improving not only the qualification of donors and methods used for donor screening, but also applying leukoreduction, pathogen reduction technology and grace period for serum. In this article, we discuss the improvement of the epidemic situation among blood donors for hepatitis B virus (HBV) and hepatitis C virus (HCV) and the increasing trend ...
Source: Acta Haematologica Polonica - July 25, 2017 Category: Hematology Source Type: research
Elevated serum concentrations of β-2-microglobulin are often found at the time of diagnosis of hemophagocytic lymphohistiocytosis in adults with lymphoid and myeloid malignancies
Conclusions: Elevated serum B2M level is a frequent finding at the time of hM-HLH diagnosis in adults. It seems to be a useful indicator of HLH for its early detection and evaluation afterward, as well as for immediate therapeutic intervention. Further prospective investigations answering the question whether serum B2M can be used as a prognostic factor in hM-HLH would be of interest. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - July 25, 2017 Category: Hematology Source Type: research
Iksazomib u chorych z nawrotowym lub opornym na leczenie szpiczakiem plazmocytowym
Publication date: Available online 23 July 2017 Source:Acta Haematologica Polonica Author(s): Krzysztof Giannopoulos, Wiesław Wiktor Jędrzejczak, Krzysztof Jamroziak, Dominik Dytfeld, Tadeusz Robak, Andrzej Hellmann Ixazomib is a new agent registered in combination with lenalidomide and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. The drug is the first oral proteasome inhibitor. Registration data show improvement in progression-free survival time (20.6 vs 14.7 months, p=0.01) but recent analysis in Asian population also in overall survival (...
Source: Acta Haematologica Polonica - July 23, 2017 Category: Hematology Source Type: research
Efficacy and safety of bosutinib in the second and third line of treatment in chronic myeloid leukemia
Publication date: Available online 10 July 2017 Source:Acta Haematologica Polonica Author(s): Bogdan Ochrem, Tomasz Sacha (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - July 11, 2017 Category: Hematology Source Type: research
Mo żliwości leczenia indukcyjnego chorych na szpiczaka plazmocytowego kwalifikujących się do chemioterapii wysokodawkowanej wspomaganej autologiczną transplantacją komórek krwiotwórczych a aktualne zalecenia Polskiej Grupy Szpiczakowej
Publication date: Available online 15 June 2017 Source:Acta Haematologica Polonica Author(s): Agnieszka Druzd-Sitek, Jan Walewski Despite significant progress in the treatment of multiple myeloma, it still remains an incurable disease. The introduction of new drugs has contributed to the increased overall survival of patients diagnosed with multiple myeloma and significantly improved their quality of life. Proteasome inhibitors, immunomodulators and monoclonal antibodies are often used in combination with chemotherapeutic agents. Despite the indisputable role of the new drugs for the treatment of myeloma, high-dose che...
Source: Acta Haematologica Polonica - June 16, 2017 Category: Hematology Source Type: research
Metastasis of solid tumors into bone marrow – Single center experience
Conclusions: Unexplained hematological abnormalities should arise the suspicion of bone marrow metastases. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - May 31, 2017 Category: Hematology Source Type: research
Ekspresja CD10 na minimalnych kom órkach resztkowych u dzieci z ostrą białaczką limfoblastyczną B-komórkową
Publication date: Available online 27 May 2017 Source:Acta Haematologica Polonica Author(s): Joanna Włodek, Karolina Bukowska-Strakova, Anna Pituch-Noworolska, Walentyna Balwierz, Marta Surman (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - May 27, 2017 Category: Hematology Source Type: research
Primary Hodgkin lymphoma of the nasopharynx: Case report
We present a case of a 43-year old man with isolated Hodgkin disease localized in the nasopharynx who presented with a complaint of bilateral nasal congestion. Primary location of Hodgkin lymphoma (HL) in the non-lymphoid tissue is very uncommon and the primary isolated involvement of the nasopharynx has been described in 35 cases in the worldwide literature. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - May 26, 2017 Category: Hematology Source Type: research
