Postępy w leczeniu agresywnych chłoniaków z obwodowych komórek T
Publication date: Available online 11 March 2015 Source:Acta Haematologica Polonica Author(s): Anna Czyż Peripheral T-cell lymphoma (PTCL) is relatively uncommon disorder representing only 8–15% of all non-Hodgkin lymphoma. The nodal types of PTCL, which include PTCL not otherwise specified, anaplastic large cell lymphomas (ALCLs), and angioimmunoblastic T cell lymphoma, are a heterogenous group of diseases that are challenging to treat. Although the outcome of patients with PTCL, with the exception of ALK-positive ALCL, is worse than that of patients with B cell lymphomas, they are treated similarly with the CHOP ...
Source: Acta Haematologica Polonica - March 12, 2015 Category: Hematology Source Type: research
Chłoniak rozlany z dużych limfocytów B – czy R-CHOP-21 jest leczeniem optymalnym?
Publication date: Available online 5 March 2015 Source:Acta Haematologica Polonica Author(s): Krzysztof Warzocha The last decade has witnessed significant advances in understanding the pathogenesis of diffuse large B-cell lymphoma (DLBCL). This has been evidenced by a 2008 classification published by the World Health Organisation (WHO), describing several clinical-pathologically distinct subtypes of DLBCL as well as at least two molecular categories which include GCB (germinal centre B-cell like) and ABC (activated B-cell like) DLBCL. Hence in such cases, designing any uniform or effective therapy is practically impos...
Source: Acta Haematologica Polonica - March 6, 2015 Category: Hematology Source Type: research
Przewlekłe nowotwory mieloproliferacyjne Ph ujemne – czerwienica prawdziwa i nadpłytkowość samoistna – kiedy hydroksykarbamid jest nieskuteczny
Publication date: Available online 5 March 2015 Source:Acta Haematologica Polonica Author(s): Joanna Góra-Tybor Polycythaemia Vera (PV) and Essential Thrombocythaemia (ET) are classical Chronic Myeloproliferative Neoplasms BCR-ABL(-). Despite their low incidence rates, survival of PV and ET patients is high, thereby making up a significant proportion of those cared for at the haematology clinic. Most patients requiring cytoreductive therapy receive hydroxycarbamide (HU) as the drug of choice, however around 20% prove to be either HU resistant or intolerant. In such cases, this article discusses the therapeutic option...
Source: Acta Haematologica Polonica - March 6, 2015 Category: Hematology Source Type: research
Zespół hemofagocytowy
Publication date: Available online 5 March 2015 Source:Acta Haematologica Polonica Author(s): Kazimierz Kuliczkowski In this short presentation the most important features of hemophagocytic lymphohistiocytosis in children and adults are presented with pathogenesis, symptoms and treatment. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - March 6, 2015 Category: Hematology Source Type: research
Rozsiane krzepnięcie wewnątrznaczyniowe w ostrych białaczkach
Publication date: Available online 2 March 2015 Source:Acta Haematologica Polonica Author(s): Krzysztof Chojnowski An overt DIC is diagnosed in 10% to 20% of patients with acute leukemia, and bleeding manifestations prevail over thrombosis, with the highest and most harmful clinical impact in acute promyelocytic leukemia (APL). Pathogenic mechanisms include a series of intrinsic properties of malignant cells, able to directly activate the coagulation system or to stimulate prothrombotic effects by the host cells. Moreover, chemotherapy or concomitant infections play an important concurrent role. The most characteristi...
Source: Acta Haematologica Polonica - March 3, 2015 Category: Hematology Source Type: research
Leczenie chorych z chłoniakami i współistniejącym zakażeniem wirusami HCV, HBV lub HIV
Publication date: Available online 2 March 2015 Source:Acta Haematologica Polonica Author(s): Ewa Kalinka-Warzocha Patients with non-Hodgkin's lymphoma (NHL) and coexisting infection with HBV, HCV or HIV constitute a major problem for clinicians concerning interdependence of the viral infection, lymphoma and antineoplatistic treatment. In patients with NHL and HCV infections complex virology diagnostics should be performed before lymphoma treatment is administered. If there are no indications to initiate antiviral therapy, the lymphoma treatment should be administered like in a subject without HCV infection. The risk ...
Source: Acta Haematologica Polonica - March 3, 2015 Category: Hematology Source Type: research
Szpiczak plazmocytowy z niewydolnością nerek jako wyzwanie terapeutyczne
Publication date: Available online 2 March 2015 Source:Acta Haematologica Polonica Author(s): Sebastian Grosicki One of the first symptoms of multiple myeloma (MM) can be renal insufficiency (RI). Elevated concentration of serum creatinine states is already present at the time of diagnosis in 20–50% of patients with MM. The prognosis for patients with a serum creatinine >2.0mg/dL is very bad and is found for only approximately 6 months. Improvement of renal function in MM can only be achieved through a comprehensive therapeutic treatment, but mainly by the quick start of modern chemotherapy. Bortezomib in com...
Source: Acta Haematologica Polonica - March 3, 2015 Category: Hematology Source Type: research
Ostre białaczki szpikowe – leczenie postaci nawrotowych i opornych
Publication date: Available online 2 March 2015 Source:Acta Haematologica Polonica Author(s): Beata Piątkowska-Jakubas , Agnieszka Kunicka-Sporek Relapsed and refractory acute myeloid leukemia (AML) is defined by clinical and biologic features that predict their poor response to therapy. Despite even the most aggressive and well-developed strategies for treatment, most patients succumb to the disease. No currently available treatment has demonstrated consistent efficacy in terms of salvage therapy or long-term survival in this group of patients. This review will discuss some of the emerging strategies: targeted mole...
Source: Acta Haematologica Polonica - March 3, 2015 Category: Hematology Source Type: research
Zarys objawów klinicznych, leczenia oraz trudności w rozpoznawaniu choroby Gauchera
Publication date: Available online 28 February 2015 Source:Acta Haematologica Polonica Author(s): Alicja Markuszewska-Kuczyńska , Maciej Machaczka Gaucher disease, a rare autosomal recessive disorder caused by the deficient activity of the lysosomal enzyme glucocerebrosidase, can be difficult to diagnose in the absence of a known affected family member. This is particularly true in non-Jewish patients with mild phenotypes due to the incomplete awareness of signs and symptoms of Gaucher disease among physicians (e.g., internists). Here, we present an outline of clinical manifestations of Gaucher disease with a partic...
Source: Acta Haematologica Polonica - March 1, 2015 Category: Hematology Source Type: research
Powikłania infekcyjne w nowotworach mieloproliferacyjnych w dobie terapii celowanych
Publication date: Available online 28 February 2015 Source:Acta Haematologica Polonica Author(s): Krzysztof Lewandowski Introduction of tyrosine kinase inhibitors (TKI) to therapy of myeloproliferative neoplasms (MPN) improved prognosis in this group of patients. Progress was especially noted in the therapy of patients with chronic myeloid leukemia (CML) and Philadelphia negative MPN, especially myelofibrosis and polycythaemia vera. Specific TKI (imatinib, nilotinib, dasatinib in a case of chronic myeloid leukemia and ruxolitinib in a case of Philadelphia negative MPN) inhibits BCR-ABL thyrosine kinase and Janus kinas...
Source: Acta Haematologica Polonica - March 1, 2015 Category: Hematology Source Type: research
Ostra białaczka limfoblastyczna – leczenie postaci nawrotowych i opornych
Publication date: Available online 28 February 2015 Source:Acta Haematologica Polonica Author(s): Sebastian Giebel Relapse is a major cause of mortality in adult acute lymphoblastic leukemia. Prognosis of patients with relapsed and refractory disease is very poor. Treatment should be focused on achievement of complete remission (CR) followed by allogeneic hematopoietic stem cell transplantation. Conventional chemotherapy results in relatively high CR rate, however, duration of the response is short. The use of humoral and cellular forms of immunotherapy may markedly improve the prognosis. The efficacy of this kind of ...
Source: Acta Haematologica Polonica - March 1, 2015 Category: Hematology Source Type: research
Jak postępujemy u chorego z zespołem hipereozynofilowym?
Publication date: Available online 28 February 2015 Source:Acta Haematologica Polonica Author(s): Grzegorz Helbig , Sławomira Kyrcz-Krzemień Hypereosinophilic syndrome (HES) is a group of rare disorders characterized by marked and persistent blood hypereosinophilia and documented as eosinophilia-attributable organ impairment. Discovery of some novel genetic abnormalities let to the categorization of HES patients into a common group of myeloid and lymphoid neoplasms with eosinophilia and recurrent gene rearrangements: platelet-derived growth factor receptor α and β (PDGFRA/B) and fibroblast growth factor receptor ...
Source: Acta Haematologica Polonica - March 1, 2015 Category: Hematology Source Type: research
Rola przeciwciał monoklonalnych anty CD30 i anty PD-1 w terapii nawrotowego/opornego chłoniaka Hodgkina
This article summarizes the possibilities of treatment of relapsed/refractory Hodgkin lymphoma with monoclonal antibodies. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - March 1, 2015 Category: Hematology Source Type: research
Szpiczak plazmocytowy wysokiego ryzyka
Publication date: Available online 28 February 2015 Source:Acta Haematologica Polonica Author(s): Anna Dmoszyńska Multiple myeloma is a very heterogeneous disease. Though distinctive, several subgroups of the disease have been identified basing on pathological and clinical features. It is generally accepted that high risk myeloma could be defined as a subtype of disease leading to death within 24 months. Many prognostic parameters help to identify high risk myeloma including age, renal insufficiency, comorbities, proliferation activity and genetic abnormalities. Basing on selective prognostic factors, some risk strat...
Source: Acta Haematologica Polonica - March 1, 2015 Category: Hematology Source Type: research
Przewlekła białaczka limfocytowa wysokiego ryzyka
Publication date: Available online 1 March 2015 Source:Acta Haematologica Polonica Author(s): Tadeusz Robak Chronic lymphocytic leukemia (CLL) is predominantly a disease of the elderly, with uniquely heterogeneous course. Advanced age has consistently been associated with a poor prognosis in patients with CLL, predominantly due to the frequent occurrence of comorbid conditions. Older and/or comorbid patients with CLL may not tolerate more aggressive approach and in these patients, chlorambucil, especially combined with anti-CD20 monoclonal antibodies, is recommended as the first-line treatment. In physically fit patie...
Source: Acta Haematologica Polonica - March 1, 2015 Category: Hematology Source Type: research
