Bilateral peripheral facial palsy secondary to Waldenström's macroglobulinemia. A case report and literature review
This report describes a case of bilateral FNP as initial presentation of a Waldenström's macroglobulinemia and discuss treatment. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - November 7, 2014 Category: Hematology Source Type: research
Pierwotna małopłytkowość immunologiczna u dzieci w świetle współczesnych definicji
Conclusions Contemporary definitions allow for more adequate categorization on most of the patients with primary immune thrombocytopenia considering the specific clinical aspects and different natural history of primary ITP in children. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Wpływ cytotoksyczny R-amfinazy, endorybonukleazy o działaniu przeciwnowotworowym, na komórki chłoniaka rozlanego z dużych komórek B w warunkach in vitro
Publication date: January–March 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 1 Author(s): Małgorzata Zwolińska , Barbara Cebula-Obrzut , Magdalena Witkowska , Agata Majchrzak , Aleksandra Mędra , Piotr Smolewski Onconase (ONC) and R-Amphinase (R-AM) are enzymes with anti-tumor activity, belonging to pancreatic ribonuclease A family, received from eggs collected from frog Rana pipiens. Both proteins can induce death of some types of neoplastic cells by inhibition of protein synthesis, cell growth and proliferation. The aim of this study was to assess the cytotoxicity of R-AM, used alone or in com...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Skuteczność liposomalnej cytarabiny w leczeniu pierwotnego i wtórnego zajęcia ośrodkowego układu nerwowego w przebiegu chłoniaków nieziarniczych – ocena retrospektywna pacjentów leczonych w Klinice Hematologii UJ CM
Publication date: January–March 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 1 Author(s): Monika Długosz-Danecka , Wojciech Jurczak , Katarzyna Krawczyk , Agnieszka Giza , Aleksander B. Skotnicki Intrathecally-administered liposomal cytarabine (DepoCyte – slow release formula) is an efficient way of treatment in primary and secondary central nervous system (CNS) involvement in patients with non-Hodgkin lymphoma. Thirty-six patients with CNS lymphoma were analyzed. Median age was 48 years (18–73). There were 18 males and 18 females. In patients with lymphoma infiltrations circumscribed to cerebr...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Jak wybrać koncentrat czynnika krzepnięcia dla dziecka chorego na hemofilię?
Publication date: January–March 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 1 Author(s): Anna Klukowska The introduction of the coagulation factor VIII and IX concentrates has changed the treatment of haemophilia patients dramatically. The concentrates were produced from pooled human plasma in the beginning. During the 1990s of the 20th century, recombinant factor VIII was accessed, then factor IX was introduced. The modern methods of elimination and inactivation of viruses led to the development of safe plasma-derived products. However, minimal risk of viral transmission is still greater by plasma-der...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Klasyfikacja barier stojących na drodze do przestrzegania zaleceń terapeutycznych u chorych na nowotwory układu krwiotwórczego
This article provides a review of methods used to assess adherence and factors influencing adherence behavior, with special emphasis on psychological types of patients. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Czynniki warunkujące aktywność terapeutyczną L-asparaginazy
Publication date: January–March 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 1 Author(s): Justyna Walenciak , Beata Zalewska-Szewczyk L-asparaginase (L-asp) is the basis of contemporary protocols used in the treatment of pediatric acute lymphoblastic leukemia and non-Hodgkin lymphomas. The key factor during L-asparaginase treatment is achieving sufficient serum activity of the drug during particular time period. There are several specified factors influencing L-asp activity. One is the preparation of the enzyme and their different pharmacokinetics. The other is L-asparaginase inactivation due to immuno...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Dwu-, trzy- i czterolekowe schematy w leczeniu pierwszoliniowym szpiczaka plazmocytowego z uwzględnieniem efektów terapii z zastosowaniem bortezomibu
Publication date: January–March 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 1 Author(s): Artur Jurczyszyn , Norbert Grząśko , Jan Maciej Zaucha The approval of bortezomib for the treatment of multiple myeloma in 2003 was a major breakthrough in the management of myeloma patients. Since then some combinations of bortezomib with other agents were proved to be active in preclinical investigations and were subsequently used in clinical trials testing new regimens. First observations with bortezomib-based combined therapies were made in patients with refractory and relapsed multiple myeloma, although th...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Cytogenetyczne i molekularne uwarunkowania agresywnej postaci przewlekłej białaczki limfocytowej
Publication date: January–March 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 1 Author(s): Anna Grenda , Michał Budzyński , Agata A. Filip Chronic lymphocytic leukemia (CLL) mainly affects people older than 60 years. Accumulation of morphologically mature but dysfunctional B-lymphocytes in the bone marrow, lymph nodes and peripheral blood is a characteristic feature of this disease. Chromosomal aberrations are observed in lymphocytes of most CLL patients. Typical alterations include deletions of 13q14 and 11q, trisomy 12, and deletions of 17p. Altered expression of the genes located within involved r...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Znaczenie mutacji genów modulujących zmiany epigenetyczne w ostrej białaczce szpikowej
Publication date: January–March 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 1 Author(s): Małgorzata Zając , Krzysztof Giannopoulos The epigenetic regulation is a complex process that affects the gene expression. Recent studies revealed abberant DNA methylation patterns in acute myeloid leukemia (AML) patients suggesting the significant role of these alterations in leukemogenesis. Additionally, the next generation sequencing (NGS) technology uncover mutations of IDH1/2, TET2, DNMT3A and EZH2 genes involved in DNA methylation processes or post translational histone modifications. Although, the functio...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Bortezomib w terapii skojarzonej: dwa, trzy czy cztery leki?
Publication date: January–March 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 1 Author(s): Krzysztof Jamroziak (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Aktualizacja zaleceń Polskiej Grupy Szpiczakowej dotyczących rozpoznawania i leczenia dyskrazji plazmocytowych w 2014 roku
Publication date: January–March 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 1 Author(s): Anna Dmoszyńska , Wiesław Wiktor Jędrzejczak , Sebastian Giebel , Adam Walter-Croneck , Krzysztof Giannopoulos (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Wspomnienie Profesora Johna Michaela Goldmana (1938–2013)
Publication date: January–March 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 1 Author(s): Andrzej Hellmann , Tadeusz Robak (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Test suchej kropli w diagnostyce choroby Gauchera i Niemanna-Picka
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Bożena Sokołowska In this paper there is a presentation of early results of the DBS test as a diagnostic for Gaucher and Niemann-Pick diseases. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Pierwotny chłoniak ośrodkowego układu nerwowego – opis przypadku
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Edyta Ponikowska-Szyba , Marcin Pasiarski , Jacek Paluch , Stanisław Góźdź Primary central nervous system lymphoma (PCNSL) is a rare malignancy with an aggressive clinical course. Diffuse large B cell lymphoma (DLBCL) accounts for 95% of the recorded cases. Although therapeutic standards are lacking, high dose methotrexate and radiotherapy are the backbone of treatment for this group of patients. Herein we present a patient who having been treated in our site with immunochemotherapy and radiotherapy achieved co...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
