Dwu-, trzy- i czterolekowe schematy w leczeniu pierwszoliniowym szpiczaka plazmocytowego z uwzględnieniem efektów terapii z zastosowaniem bortezomibu

Publication date: January–March 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 1 Author(s): Artur Jurczyszyn , Norbert Grząśko , Jan Maciej Zaucha The approval of bortezomib for the treatment of multiple myeloma in 2003 was a major breakthrough in the management of myeloma patients. Since then some combinations of bortezomib with other agents were proved to be active in preclinical investigations and were subsequently used in clinical trials testing new regimens. First observations with bortezomib-based combined therapies were made in patients with refractory and relapsed multiple myeloma, although there are rising data from studies with newly diagnosed myeloma patients, both elderly and autologous stem cell transplantation eligible. Commonly used combined therapies with bortezomib included regimens that combine this drug with corticosteroids, immunomodulatory drugs like thalidomide and lenalidomide, alkylating agents or anthracyclines. They were showed to be very active in producing high response rate and prolonged progression-free survival, although overall survival benefit was not demonstrated in a large proportion of studies, particularly in patients younger than 65 years and were given high-dose chemotherapy with autologous stem cell support. Moreover, multiagent combined therapies were showed to produce more adverse events and to be worse tolerated than combinations of bortezomib with only one or two drugs, which suggested a necessity for careful c...
Source: Acta Haematologica Polonica - Category: Hematology Source Type: research