Przypadek 12-letniego chłopca z ostrą białaczką limfoblastyczną po zgodnym w układzie ABO allo-HSCT, u którego wykryto obecność przeciwciał klasy IgG o swoistości anty-A1
Publication date: Available online 23 July 2015 Source:Acta Haematologica Polonica Author(s): A. Janusz, J. Janusz, G. Domagała, J. Skowrońska, A. Grajewska, B. Drybańska, U. Świnder This review suggested that if there is compatibility ABO between recipient and donor, immunohematologicial research before allo-HSCT (when blood is A and AB group) should also include the research of the serum donor with A1 group red blood. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - July 24, 2015 Category: Hematology Source Type: research
Niezgodne przetoczenie składników krwi w czasie pilnej transfuzji – opis przypadku
Publication date: Available online 23 July 2015 Source:Acta Haematologica Polonica Author(s): A. Jaźwińska-Curyłło, K. Kominek, J. Korzenecka (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - July 24, 2015 Category: Hematology Source Type: research
Komunikacja w hematologii
Publication date: Available online 23 July 2015 Source:Acta Haematologica Polonica Author(s): Wiesław Skrzyński The doctor-patient relationship is an extremely vital determinant in the process of diagnosis and treatment. Two people meet, two worlds consisting of different genetic features, experiences, family conditions, interests, beliefs, emotions and such a difficult diagnosis. Myeloma, lymphoma, and leukemia brings about a hostile connotation. The hematologist-patient relationship is difficult and asymmetrical from the very beginning. With the advantage of knowledge and competence, which enable a doctor to appl...
Source: Acta Haematologica Polonica - July 24, 2015 Category: Hematology Source Type: research
Chłoniaki agresywne z komórek B z podwójną/potrójną translokacją – double/triple hit lymphoma
Publication date: Available online 17 July 2015 Source:Acta Haematologica Polonica Author(s): Jan Walewski Large B-cell lymphoma with cytogenetically detected rearrangement and/or increased copy number of MYC, BCL2, and/or BCL6 are frequently termed double/triple hit lymphoma (DHL/THL) due to molecular, biologic, and clinical similarities. In particular, patient outcome after standard therapy is disappointing; there is a high risk of central nervous system involvement, and resistance to second-line treatment in case of recurrent or progressive disease. DHL/THL are not recognized as a separate diagnostic entity, and s...
Source: Acta Haematologica Polonica - July 18, 2015 Category: Hematology Source Type: research
Aktualne miejsce nilotynibu i dazatynibu w leczeniu przewlekłej białaczki szpikowej
Publication date: Available online 17 July 2015 Source:Acta Haematologica Polonica Author(s): Tomasz Sacha, Joanna Wącław Tyrosine kinase inhibitors (TKI) have revolutionized the practise of treatment of chronic myeloid leukemia. The emergence of resistance to imatinib – first TKI – has led to the development of second-generation TKI's (2GTKI). Nilotinib and dasatinib are 2GTKI's routinely used in the tretament of CML patients intolerant or resistant to imatinib since couple of years. The approval of nilotinib and dasatinib in newly diagnosed chronic-phase CML patients was granted based on the results of stud...
Source: Acta Haematologica Polonica - July 17, 2015 Category: Hematology Source Type: research
Fizjoterapia po zabiegu endoprotezoplastyki stawu skokowego u pacjenta chorego na hemofilię – opis przypadku
Conclusions Function of the ankle joint significantly improved, the level of pain decreased and time needed to complete the TUG test shortened. The range of motion as well as strength of the muscles acting on the ankle joint improved slightly. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - June 30, 2015 Category: Hematology Source Type: research
Koncentraty czynników krzepnięcia o przedłużonym działaniu w leczeniu hemofilii
Publication date: Available online 2 May 2015 Source:Acta Haematologica Polonica Author(s): Anna Klukowska , Krystyna Zawilska The treatment of patients with haemophilia A and B is based on substitution of factor VIII and factor IX. The half-life of factor VIII (about 11hours) and factor IX (about 18hours) are rather short, so frequency of prophylactic infusions of factor VIII and factor IX concentrates are not less than 3 or 2 times a week. The development of new factor VIII and factor IX concentrates with longer half-lives makes possible the prolongation of time between doses and the improvement of prophylaxis effi...
Source: Acta Haematologica Polonica - May 2, 2015 Category: Hematology Source Type: research
Zalecenia Polskiej Grupy Szpiczakowej dotyczące rozpoznawania i leczenia szpiczaka plazmocytowego oraz innych dyskrazji plazmocytowych na rok 2015
Publication date: Available online 24 April 2015 Source:Acta Haematologica Polonica Author(s): Anna Dmoszyńska , Adam Walter-Croneck , Lidia Usnarska-Zubkiewicz , Beata Stella-Hołowiecka , Jan Walewski , Grzegorz Charliński , Wiesław Wiktor Jędrzejczak , Elżbieta Wiater , Ewa Lech-Marańda , Dominik Dytfeld , Mieczysław Komarnicki , Krzysztof Jamroziak , Tadeusz Robak , Artur Jurczyszyn , Joanna Mańko , Aleksander Skotnicki , Sebastian Giebel , Iwona Hus , Ryszard Czepko , Janusz Meder , Bogdan Małkowski , Krzysztof Giannopoulos New drugs introduced in recent years to the therapy of multi...
Source: Acta Haematologica Polonica - April 25, 2015 Category: Hematology Source Type: research
Zajęcie ośrodkowego układu nerwowego w przebiegu szpiczaka plazmocytowego – opis przypadku i przegląd literatury
Publication date: Available online 23 April 2015 Source:Acta Haematologica Polonica Author(s): Artur Jurczyszyn , Magdalena Olszewska-Szopa , Szymon Fornagiel , Aleksander Skotnicki In multiple myeloma extramedullary involvement occurs in 13% of patients. Central nervous system (CNS) involvement is extremely rare and comprises 1% of cases. Review of literature shows only limited data on this subject and consists mostly of few case reports. Scarce knowledge about CNS involvement in the course of multiple myeloma makes its diagnosis and treatment very difficult and challenging. The authors describe a clinical case wh...
Source: Acta Haematologica Polonica - April 24, 2015 Category: Hematology Source Type: research
Substytucja immunoglobulin u chorych na przewlekłą białaczkę limfocytową i szpiczaka plazmocytowego
Publication date: Available online 20 April 2015 Source:Acta Haematologica Polonica Author(s): Krzysztof Jamroziak , Agnieszka Końska Infections play an important role in the mortality of patients with chronic lymphocytic leukemia (CLL) and plasma cell myeloma (PMC). Susceptibility to infections in CLL and MM results from complex defects of humoral and cell-mediated immunity including hypogammaglobulinemia. Potential methods of prevention of bacterial infections in CLL and PCM include vaccination against Streptococcus pneumoniae and Haemophilus influenzae, prophylactic use of antibiotics and intravenous or subcutane...
Source: Acta Haematologica Polonica - April 20, 2015 Category: Hematology Source Type: research
Dziesięciolecie Polskiej Grupy Szpiczakowej – historia i osiągnięcia
Publication date: Available online 20 April 2015 Source:Acta Haematologica Polonica Author(s): Anna Dmoszyńska , Adam Walter-Croneck , Norbert Grząśko , Lidia Usnarska-Zubkiewicz , Jakub Dębski , Joanna Mańko , Wioletta Kamińska , Paulina Własiuk , Krzysztof Giannopoulos Polish Myeloma Study Group (PMSG) was created in 2005 during XXI Congress of Polish Society of Haematology and Transfusion Medicine with the initiative of prof. Anna Dmoszynska as a forum for exchanging experiences and for clinical and scientific cooperation focused on the issue of multiple myeloma (MM). The main aims of PMSG include de...
Source: Acta Haematologica Polonica - April 20, 2015 Category: Hematology Source Type: research
Peptide-based immunotherapy in multiple myeloma
Publication date: Available online 17 April 2015 Source:Acta Haematologica Polonica Author(s): Marta Podgórniak , Joanna Zaleska , Krzysztof Giannopoulos The modifications of the immune system with immunomodulatory drugs or monoclonal antibodies are still insufficient to obtain long-lasting complete remissions in most of the multiple myeloma patients (MM). Peptide-based immunotherapy combined with an autologous hematopoietic stem cell transplantation, immunomodulatory drugs or monoclonal antibodies might represent novel therapeutic strategies, that might retain immune control on disease development and progression ...
Source: Acta Haematologica Polonica - April 17, 2015 Category: Hematology Source Type: research
Allogeneic transplantation in multiple myeloma – How, when or at all?
Publication date: Available online 11 April 2015 Source:Acta Haematologica Polonica Author(s): Gösta Gahrton Allogeneic transplantation (allo) of patients with multiple myeloma is a controversial treatment due to high transplant related mortality (TRM) with myeloablative conditioning before the transplant. However, using reduced intensity conditioning (RIC) and previous autologous transplantation (auto) has dramatically reduced TRM. This, in combination with a lower relapse/progression rate, has in two out of six prospective studies resulted in prolongation of both progression free survival (PFS) and overall survival...
Source: Acta Haematologica Polonica - April 11, 2015 Category: Hematology Source Type: research
Zakażenia wirusowe u dzieci po przeszczepieniu komórek krwiotwórczych
Conclusions Viral infections in children after HSCT occur in over 50% of the patients after allo-HSCT and 10% after auto-HSCT. Mixed and multiple infections occur frequently. Infections with CMV, EBV, BKV or ADV contribute to deaths in 5–10% patients. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - April 2, 2015 Category: Hematology Source Type: research
Chłoniak z komórek płaszcza – nawrót po leczeniu pierwszej linii
Publication date: Available online 10 March 2015 Source:Acta Haematologica Polonica Author(s): Michał Szymczyk Mantle cell lymphoma remains a challenge for the modern oncology and hematology. It combines the unfavorable features of non-Hodgkin lymphomas: it is recurrent and incurable as indolent lymphomas and it grows rapidly as most aggressive lymphomas. In most cases the disease develops rapidly and is characterized by persistent relapses. The available treatment options do not offer satisfying results. So far, there is no therapeutic standard available neither in the first nor in the subsequent lines of treatment....
Source: Acta Haematologica Polonica - March 12, 2015 Category: Hematology Source Type: research
