Diagnostyka i leczenie postępującej wieloogniskowej leukoencefalopatii
Publication date: Available online 25 February 2015 Source:Acta Haematologica Polonica Author(s): Monika Kulma-Kreft , Krzysztof Leśniewski-Kmak , Jan Maciej Zaucha Progressive multifocal leukoencephalopathy (PML) is a rare but a very serious complication associated inter alia with the use of new biological and immunomodulatory agents that cause long-lasting immunosuppression. This also applies to rituximab, commonly used for treatment of B-cell non-Hodgkin lymphoma (NHL) patients. PML may develop during, as well as after, completion of treatment with rituximab. Diagnosis of PML is not easy and poses a significant ...
Source: Acta Haematologica Polonica - February 26, 2015 Category: Hematology Source Type: research
Rekomendacje Kolegium Medycyny Laboratoryjnej w Polsce (KMLP) dotyczące wykonywania biopsji aspiracyjnej i oceny cytologicznej szpiku kostnego
This article contains the rules, which should be followed during bone marrow aspirate examination, with the aim to improve the quality of the analysis. The technique of aspiration was presented in detail. The list of data, which should be transferred together with the sample to the laboratory, the methods of preparing and staining of smears, rules for microscopic assessment and preparing of final report are also included. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - February 18, 2015 Category: Hematology Source Type: research
Pierwotny chłoniak ośrodkowego układu nerwowego u pacjentów immunokompetentnych
Publication date: Available online 13 February 2015 Source:Acta Haematologica Polonica Author(s): Edyta Ponikowska-Szyba Primary central nervous system lymphoma (PCNSL) is a rare malignancy, exclusively arising in central nervous system (CNS) and in the intraocular compartment, accounting for 4% of all intracranial tumors. Recently, the incidence of PCNSL is progressively increasing in immunocompetent patients and in the elderly age group. CNS involvement and diffuse large B cell lymphoma (DLBCL) histology in 95% of cases are responsible for an aggressive clinical course of this malignancy. Particular microenvironment...
Source: Acta Haematologica Polonica - February 14, 2015 Category: Hematology Source Type: research
Obinutuzumab jako nowa szansa terapeutyczna dla chorych na przewlekłą białaczkę limfocytową
This article presents the review of current publications concerning the mechanism of action, efficacy and safety of obinutuzumab. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - February 8, 2015 Category: Hematology Source Type: research
Prognostic significance of the number and type of extra nodal localizations of DLBCL in the rituximab era
Conclusions Neither the number of extra nodal lesions nor their localization affects prognosis in patients with DLBCL in the rituximab era. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - January 14, 2015 Category: Hematology Source Type: research
Delayed recovery of kidney function in a multiple myeloma patient treated with high cut-off hemodialysis: A case report
We present a case of a 68-year-old woman with dialysis dependent acute kidney injury secondary to multiple myeloma. The treatment consisted of plasma exchange, 10 sessions of high-cut-off hemodialysis and induction chemotherapy. Free light chain concentration (FLC) was reduced from 1900mg/l to 584mg/l (a 70% reduction). Recovery of kidney function was observed 3 months after hospital admission and discontinuation of dialysis was possible. The case is quite unusual because of the delay in renal recovery. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - January 9, 2015 Category: Hematology Source Type: research
Clinical aspects of prophylaxis and treatment of CNS disease in lymphoma patients
Publication date: Available online 5 December 2014 Source:Acta Haematologica Polonica Author(s): Małgorzata Krawczyk-Kuliś , Sławomira Kyrcz-Krzemień Currently, infiltration of the central nervous system (CNS) in lymphoma patients is an unfavorable prognostic factor contributing to shorter survival. In these cases, immunophenotypisation has become important for evaluation of cerebrospinal fluid cells – especially in the so-called “subclinical form of CNS involvement.” Other methods used in these cases include diagnostic imaging and cytological examination. Therapy protocols, including the prophylactic intra...
Source: Acta Haematologica Polonica - January 8, 2015 Category: Hematology Source Type: research
The outcome of primary mediastinal B-cell lymphoma in a single center experience
Conclusions The vast majority of PMBCL patients are susceptible to immunochemotherapy with a high response rate achieved after R-DA-EPOCH/R-CHOP regimens. AHSCT seems to be an option for fit patients with disease chemosensitivity. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - January 8, 2015 Category: Hematology Source Type: research
Standardy diagnostyczne zespołów mielodysplastycznych u osób dorosłych wg zaleceń EuropeanLeukemiaNet
Publication date: Available online 31 December 2014 Source:Acta Haematologica Polonica Author(s): Agnieszka Pluta , Anna Krawczyńska , Agnieszka Wierzbowska Myelodysplastic syndromes (MDS) according to WHO definition are a group of myeloid neoplasms characterized by peripheral blood cytopenias and increased risk of leukemic transformation. An accurate diagnostic procedure and risk assessment are necessary for choosing an optimal treatment option. The aim of this article is performance of MDS diagnostic standards according to European LeukemiaNet. MDS diagnosis should be based on WHO 2008 criteria with International...
Source: Acta Haematologica Polonica - January 8, 2015 Category: Hematology Source Type: research
Leczenie zespołów mielodysplastycznych wysokiego ryzyka u dorosłych wg rekomendacji European LeukemiaNet
This article presents recent European LeukemiaNet recommendations for treatment of high-risk MDS. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - November 21, 2014 Category: Hematology Source Type: research
Profilaktyka zakażeń grzybiczych u dzieci poddawanych transplantacjom komórek hematopoetycznych
Publication date: Available online 13 November 2014 Source:Acta Haematologica Polonica Author(s): Krzysztof Kałwak Invasive fungal infections (IFI) remain a very important cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT) in children. The recent study from Polish pediatric transplant centers revealed that 27.3% of children transplanted in 2012–2013 developed IFI. The highest risk was observed among patients with AML and ALL after allogeneic HSCT. Such results warrant the use of extensive antifungal prophylaxis in this cohort of patients. ECIL-4 guidelines for antifungal prophylax...
Source: Acta Haematologica Polonica - November 14, 2014 Category: Hematology Source Type: research
Assessment of lineage-specific chimerism after allogeneic stem cell transplantation
Conclusions Lineage specific chimerism as a method of high sensitivity and specificity allows for precise assessment of donor chimerism especially in clinically ambiguous situations. Assessment of erythrocyte chimerism by flow cytometry is a reliable method of monitoring erythroblastic line engraftment. Presented results are preliminary and the study is being continued. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - November 13, 2014 Category: Hematology Source Type: research
Częstość zakażeń kiłą u dawców krwi w RCKiK w Bydgoszczy w latach 2001–2013
Publication date: Available online 27 October 2014 Source:Acta Haematologica Polonica Author(s): Danuta Kaczmarek , Dominika Tomczyk Syphilis, an infectious disease caused by a spirochete pale – Treponema pallidum, has been present in Poland since the fifteenth century. The most common is transmitted through sexual relations, but it is also possible to transfer through blood transfusions. Currently, there has been an increasing incidence of new cases, and cases of congenital syphilis and recognition of the advanced forms of the disease are also growing in Poland. The aim of the study was to analyze the incidence of...
Source: Acta Haematologica Polonica - November 7, 2014 Category: Hematology Source Type: research
Functions of the Ikaros transcription factor and the role of IKZF1 gene defects in hematological malignancies
Publication date: Available online 27 October 2014 Source:Acta Haematologica Polonica Author(s): Anna Gorzkiewicz , Anna Walczewska Discovered in the early 1990s, highly conserved DNA- and protein-binding transcription factor, Ikaros, is now considered as one of the most important players in hematopoiesis and the development of certain forms of human malignancies. The Ikaros transcription factor is a multifunctional protein regulating hematopoietic stem cells (HSCs) function, coordinating self-renewal, cell survival processes, cell cycle progression and lymphopoiesis. Ikaros is also considered as one of the most impo...
Source: Acta Haematologica Polonica - November 7, 2014 Category: Hematology Source Type: research
Personalizacja leczenia chorych na chłoniaka grudkowego w dobie rutyksymabu
Publication date: Available online 27 October 2014 Source:Acta Haematologica Polonica Author(s): Maria Cioch , Karolina Radomska , Paweł Jarosz , Hanna Borowska In patients with follicular lymphoma (FL), there are several factors influencing the disease course: morphological, immunological, genetic and clinical. The therapeutic options for patients with FL contain many methods such as rituximab with different chemotherapy regimens, radioimmunotherapy, radiotherapy and hematopoietic stem cell transplantation. The modern management of FL patients should consist of personalization of therapy related to risk factors. ...
Source: Acta Haematologica Polonica - November 7, 2014 Category: Hematology Source Type: research
