Haemate P − zastosowanie w profilaktyce i leczeniu krwawień w chorobie von Willebranda oraz indukcji immunotolerancji w hemofilii A powikłanej inhibitorem
The objective of the treatment of those patients is the elimination of the inhibitor, possibly through inducing immune tolerance (IT). The efficacy of Haemate P in immune tolerance induction both in the first and consecutive lines of treatment has been demonstrated by many reports. Replacement of highly-purified and recombinant FVIII concentrates in the case of failure to induce IT to concentrates with a high vWF:RCo content may be a beneficial treatment option in another attempt of inducing IT. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - May 24, 2017 Category: Hematology Source Type: research
Metody oznaczania hemoglobiny p łodowej
Publication date: Available online 4 May 2017 Source:Acta Haematologica Polonica Author(s): Elżbieta Górska, Anna Lemańska, Katarzyna Popko The identification of the new form of hemoglobin in fetus red blood cells (HbF), different from adult hemoglobin (HbA), was made over one hundred years ago. Since this time, various methods of fetal hemoglobin measurement have been designed. Most of them are based on the different biochemical characteristics of HbF. Fetal hemoglobin's affinity for oxygen is substantially greater than that of adult hemoglobin. The first techniques for the determination of fetal hemoglobin were b...
Source: Acta Haematologica Polonica - May 5, 2017 Category: Hematology Source Type: research
Visceral varicella-zoster virus (VZV) infection as an underestimated differential diagnosis of acute abdomen in a patient after allogeneic hematopoietic stem cell transplantation
We report a case of 18-year-old male patient who 5.5 months after allogeneic hematopoietic stem cell transplant (HSCT) developed severe abdominal pain not responding to high dose of opioids. The pain was accompanied by gradually increasing activity of liver enzymes and bilirubin concentration. The patient had a history of acute GVHD and was on steroid taper. Importantly, he was also temporarily off standard acyclovir prophylaxis. Provisional diagnosis of acute cholecystitis was made, however, cholecystectomy did not improve patient's condition. Clinical picture of severe abdominal pain without clear surgical cause, resista...
Source: Acta Haematologica Polonica - March 15, 2017 Category: Hematology Source Type: research
Osoczowe st ężenie cytruliny w klinicznej ocenie toksyczności jelitowej u chorych na nowotwory złośliwe poddanych chemioterapii wysokodawkowej [Acta Haematologica Polonica 2015; 46(S): 190–191]
Publication date: Available online 11 March 2017 Source:Acta Haematologica Polonica Author(s): J. Barzał, P. Rzepecki, M. Jaworska, E. Anuszewska (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - March 11, 2017 Category: Hematology Source Type: research
Role of HLA match on results of hematopoietic stem cell transplantations from unrelated donors in children with acute leukemia and bone marrow failure syndromes
Conclusion Current data suggest that results of mismatched and matched UD-HSCT in children with acute leukemia might be comparable. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - February 27, 2017 Category: Hematology Source Type: research
Szczepienia ochronne u chorych doros łych po przeszczepieniu komórek krwiotwórczych – zalecenia sekcji do spraw zakażeń PALG
Publication date: Available online 16 February 2017 Source:Acta Haematologica Polonica Author(s): Agnieszka Piekarska, Sebastian Giebel, Grzegorz Władysław Basak, Jarosław Dybko, Kazimierz Hałaburda, Iwona Hus, Ewa Karakulska-Prystupiuk, Beata Jakubas, Patrycja Mensah-Glanowska, Piotr Rzepecki, Agnieszka Wierzbowska, Lidia Gil Infections are the most serious complications in patients undergoing hematopoietic cell transplantation (HCT). Vaccinations occur to be undeniably one of the most important prophylactic strategies and are routinely recommended in the post-transplantation period. Their use reduces th...
Source: Acta Haematologica Polonica - February 16, 2017 Category: Hematology Source Type: research
Alloimmunologiczna ma łopłytkowość noworodków
Publication date: Available online 16 February 2017 Source:Acta Haematologica Polonica Author(s): Irmina Nowak, Weronika Kubiak-Prałat, Marcin Minta, Marta Szymankiewicz, Janusz Gadzinowski, Dawid Szpecht Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is defined as a platelet count <150,000/μL due to reaction between maternal antibodies and antigens located on thrombocytes of the fetus/neonate. Such a kind of pathology occurs when a mother does not possess specific human platelet antigens (HPA), which are inherited as an infant from the father. HPA-1a is an antigen that most often causes FNAIT in the C...
Source: Acta Haematologica Polonica - February 16, 2017 Category: Hematology Source Type: research
Diagnosing Beta Thalassemia trait in a developing country
Publication date: Available online 9 February 2017 Source:Acta Haematologica Polonica Author(s): Shan-e- Rauf, Ghassan Umair Shamshad, Fareeha Mushtaq, Saleem Ahmed Khan, Nadir Ali (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - February 9, 2017 Category: Hematology Source Type: research
Emerging spread of β-thalassemia trait in Nigeria
Conclusions The outcome of this study reiterates the emergence of β-thalassemia traits and iron deficiency anaemia in different parts of Nigeria irrespective of their haemoglobin genotype status. This requires adequate specialized intervention for their diagnosis and treatment. There is therefore the need for subsequent molecular analysis to determine the β-thalassemia genes present in the studied community. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - January 20, 2017 Category: Hematology Source Type: research
Wyniki stosowania nowych metod rehabilitacji u pacjent ów z artropatią hemofilową
Publication date: Available online 19 January 2017 Source:Acta Haematologica Polonica Author(s): Janusz Zawilski, Adrian Dudek, Przemysław Lisiński Advanced arthropathy mainly of the knee, hip or ankle joint occurs even in young adults with haemophilia. It has been proved that physical training increases isometric muscular strength and proprioceptive performance in haemophilia patients. The aim of this study was to present the new methods of physiotherapy process and their effect in patients with haemophilic arthropathy. Five subjects, aged from 32 to 42 years, with severe haemophilia A or B attended physiotherapy i...
Source: Acta Haematologica Polonica - January 18, 2017 Category: Hematology Source Type: research
Zaka żenia wirusowe u dzieci po przeszczepieniu komórek krwiotwórczych: raport 2016 Polskiej Pediatrycznej Grupy ds. Zakażeń Polskiego Towarzystwa Onkologii i Hematologii Dziecięcej
Conclusions We found epidemiological trends in viral infections after HSCT in children: increase in incidence after allo-HSCT (increase EBV, appearance of CARV) and decrease after auto-HSCT. Decrease of deaths attributed to viral infections was observed in the last period of time. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - January 18, 2017 Category: Hematology Source Type: research
Genetic alterations in B-acute lymphoblastic leukemia
Publication date: Available online 6 December 2016 Source:Acta Haematologica Polonica Author(s): Mohammadi Seyedeh Momeneh, Mohammad Nejad Daryosh, Nozad Charoudeh Hojjatollah Considerable advances have been made in treatment of acute lymphoblastic leukemia (ALL) with an overall survival rate of 85% in children, and with a great improvement in adults. Despite this improvements and the accessibility of hematopoietic stem cell transplantation, relapsed ALL remains a leading cause of childhood mortality emphasizing the need of new approaches on therapy. Understanding of the pathobiology and genetic alteration of ALL has ...
Source: Acta Haematologica Polonica - December 28, 2016 Category: Hematology Source Type: research
Single Positive Commensal Blood Culture in hospital setting is associated with higher mortality after hematopoietic stem cell transplantation
Conclusion To our knowledge this is the first report that specifically shows that short- and long-term survival after HSCT is significantly lower in patients who experience an episode of SPCBC with Staphylococcus spp. during HSCT hospitalization. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - December 28, 2016 Category: Hematology Source Type: research
Emerging spread of β-thalassaemia trait in Nigeria
Conclusions The outcome of this study reiterates the emergence of β-thalassaemia traits and iron deficiency anaemia in different parts of Nigeria irrespective of their haemoglobin genotype status. This requires adequate specialized intervention for their diagnosis and treatment. There is therefore the need for subsequent molecular analysis to determine the β-thalassaemia genes present in the studied community. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - December 28, 2016 Category: Hematology Source Type: research
Transfusion-associated graft-vs-host disease – A case report
We report a case of TA-GVHD in a 45-year-old post-hysterectomy patient after packed red blood cell transfusion from a sibling donor. The patient had fever, maculopapular rashes all over the body, elevated transaminases, and hyperglycemia after a week of the blood transfusion. Severe pancytopenia and bone marrow aplasia followed and she succumbed to her disease after 3 weeks of onset. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 26, 2016 Category: Hematology Source Type: research
