The role of SLIT–ROBO pathway in crucial cell processes during physiological and pathological conditions
Publication date: Available online 4 August 2014 Source:Acta Haematologica Polonica Author(s): Aleksandra Gołos , Agnieszka Wierzbowska The SLIT glycoproteins and their roundabout (ROBO) receptors were originally identified as axon guidance molecules that prevent axons from re-crossing the midline. In addition, the SLIT–ROBO interaction is involved in the regulation of cell migration, cell death and angiogenesis. Furthermore, it has a pivotal role during the morphogenesis, controlling the correct development of lung, kidney, liver and breast. The functions which the SLIT–ROBO fulfills during tissue morphogenesis...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Wskazania do transplantacji komórek krwiotwórczych u dzieci i młodzieży – rekomendacje Polskiej Pediatrycznej Grupy ds. Transplantacji Komórek Krwiotwórczych – 2014
This article presents the current recommendations from the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation concerning the indications for hematopoietic stem cell transplantation (HSCT) in children and adolescents suffering from hematological malignancies, solid tumours, and congenital or acquired non-malignant disorders. Indications for HSCT are established in context of the recent results of conventional treatment, i.e. obtained with non-HSCT strategies; it means transplantation is justifiable exclusively, when it significantly increases individual patient's chances to be cured, despite of the risk of H...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Dyskwalifikacja dawcy komórek krwiotwórczych w trakcie chemioterapii wysokodawkowanej u biorcy przygotowywanego do transplantacji: propozycja algorytmu postępowania ratunkowego
Conclusion We believe that the proposed algorithm of rescue procedures can facilitate the proceedings in the case of donor hematopoietic cells disqualification directly prior to transplantation. It seems reasonable to propose a discussion on the implementation of procedures to reduce the risk of similar events. To consider is typing for each patient two potential donors, collection of material for transplantation before proceeding to transplantation and collection from each patient's own material for transplantation to the rescue. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
