Wrodzona naczyniakowatość krwotoczna rozpoznana u 13-miesięcznego dziecka: opis przypadku i przegląd literatury
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Magdalena Ćwiklińska , Walentyna Balwierz , Łukasz Wyrobek , Wanda Król-Jawień Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant, rare and severe disease that results from vascular dysplasia. It is characterised by recurrent epistaxis, teleangiectasias of skin and mucosa and arteriovenous malformations in: lungs, brain, liver, gastrointestinal tract and spinal cord. Diagnosis of HHT is rarely done in early childhood, because of the gradual appearance of vascular malformations. Patients with...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Powikłania terapii niedokrwistości Blackfana i Diamonda – studium dwóch przypadków klinicznych
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Agnieszka Szymczyk , Katarzyna Radko , Arkadiusz Macheta , Marek Hus , Monika Podhorecka Diamond–Blackfan anemia (DBA) is a rare congenital hypoplastic anemia, diagnosed most frequently in early childhood. Since 1936, when it was first reported, many methods have been proposed for the treatment of the disease. Some of those are still used nowadays, though the rest have gone out of practice in the history of medicine. These approaches are broadly discussed in the literature in terms of their efficacy and safety. ...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Chorzy na szpiczaka plazmocytowego leczeni w Klinice Neurochirurgii i Neurochirurgii Dziecięcej UM w Lublinie
We describe the patients with multiple myeloma treated in Department of Neurosurgery, Medical University of Lublin. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Stare i nowe czynniki ryzyka zakrzepicy u chorych z nadpłytkowością samoistną
In this study there is a summary of old and new risk factors which may contribute to thrombotic complications in ET patients. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Danazol – możliwości wykorzystania w leczeniu chorób hematologicznych
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Arkadiusz Macheta , Agnieszka Szymczyk , Monika Podhorecka Danazol is an attenuated synthetic hormone with weak androgenic effects. It has unique properties similar to those of corticosteroids and has a structure related to testosterone and ethisterone. Danazol is widely used for endometriosis and in mammary gland dysplasia treatment. Among the others, it can be also a therapeutical option for patients with autoimmunological disorders, such as immune thrombocytopenic purpura and autoimmune hemolytic anemia. The atte...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Chorzy ze szpiczakiem plazmocytowym jako problem chirurgiczny
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Dariusz Szczepanek , Ewa Wąsik-Szczepanek , Tomasz Trojanowski Multiple myeloma (MM) is the neoplastic proliferation associated with a variety of neurological manifestations, caused by metabolic abnormalities or bone destruction. Development of a cerebral myeloma tumor is uncommon. Imaging studies include radiographic skeletal surveys, magnetic resonance imaging, computerized tomography. Treatment patients with MM include the systemic and intrathecal chemotherapy, irradiation but in some patients neurosurgery inter...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
POMALIDOMID – nowy immunomodulujący lek w terapii szpiczaka plazmocytowego
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Artur Jurczyszyn , Lidia Usnarska-Zubkiewicz , Anna Engel , Aleksandra Butrym , Grzegorz Mazur , Aleksander B. Skotnicki Multiple myeloma (MM) is a haematological disease characterized by plasma cells proliferation in bone marrow associated with damage of organs – mainly kidneys and bones. Previous therapies significantly extended the survival of patients, but still relapse is 100%. In February 2013, in USA, the Food and Drug Administration (FDA) introduced to therapy a new immunomodulatory drug – pomalidomid...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Gammapatia monoklonalna o nieustalonym znaczeniu – rola czynników genetycznych i infekcyjnych w patogenezie choroby
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Marcin Pasiarski , Artur Kowalik , Agnieszka Stelmach , Ewelina Grywalska , Stanisław Góźdź , Jacek Roliński Monoclonal gammopathy of undetermined significance (MGUS) is a disorder characterized by an increased concentration of one type of immunoglobulin following a clonal proliferation of plasma cells. The etiology and pathogenesis of MGUS are not fully understood. The risk factors of proven importance include family history and hormonal factors. Recently carried out cohort studies have shown that the molec...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Białaczkowe komórki macierzyste
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Maria Cioch , Karolina Radomska Acute myeloid leukaemia (AML) is a neoplasm originating in early haematopoietic progenitor cells. Each AML clone contains a subpopulation of leukaemic stem cells (LSCs). LSCs have the capacity to repopulate AML in NOD/SCID mice and regrow leukaemia in patients after remission period. LSCs are characterized by CD34+CD38-Lin-CD33+/-CD123+ immunophenotype. The currently available data show that LSCs play a pivotal role in drug resistance. Many studies and clinical trials are being conduct...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
The role of Th17 cells in tumor immunity
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Agnieszka Karczmarczyk , Marta Karp , Krzysztof Giannopoulos CD4+ T helper (Th) cells play an important role in modulating immune responses. Th17 cells are a newly established Th subpopulation. Th17 cells differentiate in the presence of TGF-β and IL-6 in mice or IL-1β and IL-6 in humans, depending on the transcription factor RORγt. IL-23 stabilizes the Th17 cells phenotype and helps Th17 cells acquire effector functions. Th17 secretes IL-17, IL-21, and IL-22, which play significant role in the immune response ag...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Wartość diagnostyczna i zastosowanie kliniczne biomarkerów oraz ferrytynemii w chorobie Gauchera
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Fryderyk Lorenz , Aleksander B. Skotnicki , Maciej Machaczka Gaucher disease is a progressive, multisystem lysosomal storage disorder caused by the deficient activity of the lysosomal enzyme, glucocerebrosidase (GBA), arising from autosomal recessive mutations in the GBA1 gene (1q21). There are several biomarkers used in Gaucher disease (i.e., chitotriosidase, CCL18/PARC, tartrate resistant acid phosphatase, angiotensin-converting enzyme), however, all of them have some disadvantages. It is believed that none of the...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Pierwotna mielofibroza – przegląd metod leczniczych
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Maria Cioch , Paweł Jarosz Primary myelofibrosis (PMF) is a Ph-negative myeloproliferative neoplasm (MPN), that manifests bone marrow fibrosis, cytopenias, splenomegaly, and constitutional symptoms. The conventional therapeutic options for patients with PMF consist of management of anemia, use of cytoreductive and immunomogulatory agents, and splenectomy or splenic irradiation. Cure is only achievable through allogeneic haematopoietic stem cell transplantation. The discovery of crucial role of JAK2 signaling in path...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Optymalizacja chemio- i radioterapii w leczeniu I linii chłoniaka Hodgkina
This article summarizes current possibilities of first line treatment of Hodgkin lymphoma with chemo- and radiotherapy. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
Transplantacje komórek krwiotwórczych w przewlekłej białaczce limfocytowej
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Wojciech Legieć , Iwona Hus , Marek Hus Despite the significant progress that has been made in recent years in the treatment of chronic lymphocytic leukemia (CLL), mainly due to the introduction of monoclonal antibodies, allogeneic hematopoietic cell transplantation remains the only method that could potentially cure CLL. However, because of high peritransplant mortality, this method is reserved only for patients with high-risk CLL. Autologous transplantation is currently not recommended for patients with CLL due t...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
New horizons in the treatment of chronic lymphocytic leukemia
Publication date: April–June 2014 Source:Acta Haematologica Polonica, Volume 45, Issue 2 Author(s): Tadeusz Robak Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world, accounting for approximately 30% of all leukemias in Europe and North America. Recently, significant progress in the characterization and understanding of the biology and prognosis of CLL has provided new opportunities for the development of innovative, more effective therapies. Several new anti-CD20 monoclonal antibodies directed against lymphoid cells have been developed and are under investigation in preclinical...
Source: Acta Haematologica Polonica - October 12, 2014 Category: Hematology Source Type: research
