Zaka żenia wirusowe u dzieci po przeszczepieniu komórek krwiotwórczych
Conclusions Viral infections in children after HSCT occur in over 50% of the patients after allo-HSCT and 10% after auto-HSCT. Mixed and multiple infections occur frequently. Infections with CMV, EBV, BKV or ADV contribute to deaths in 5–10% patients. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Koncentraty czynnik ów krzepnięcia o przedłużonym działaniu w leczeniu hemofilii
Publication date: September 2015 Source:Acta Haematologica Polonica, Volume 46, Issue 4 Author(s): Anna Klukowska, Krystyna Zawilska The treatment of patients with haemophilia A and B is based on substitution of factor VIII and factor IX. The half-life of factor VIII (about 11hours) and factor IX (about 18hours) are rather short, so frequency of prophylactic infusions of factor VIII and factor IX concentrates are not less than 3 or 2 times a week. The development of new factor VIII and factor IX concentrates with longer half-lives makes possible the prolongation of time between doses and the improvement of prophyla...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Ruksolitynib w leczeniu nowotwor ów mieloproliferacyjnych Ph(-)
Publication date: September 2015 Source:Acta Haematologica Polonica, Volume 46, Issue 4 Author(s): Tomasz Wróbel Ruxolitinib is the first JAK kinase inhibitor registered for the treatment of primary myelofibrosis and post-polycythaemia vera myelofibrosis and post-essential thrombocytaemia myelofibrosis. The article is a summary of current clinical data with ruxolitinib therapy both in myelofibrosis and in other Ph-negative myeloproliferative neoplasms. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Aktualne miejsce nilotynibu i dazatynibu w leczeniu przewlek łej białaczki szpikowej
Publication date: September 2015 Source:Acta Haematologica Polonica, Volume 46, Issue 4 Author(s): Tomasz Sacha, Joanna Wącław Tyrosine kinase inhibitors (TKI) have revolutionized the practise of treatment of chronic myeloid leukemia. The emergence of resistance to imatinib – first TKI – has led to the development of second-generation TKI's (2GTKI). Nilotinib and dasatinib are 2GTKI's routinely used in the tretament of CML patients intolerant or resistant to imatinib since couple of years. The approval of nilotinib and dasatinib in newly diagnosed chronic-phase CML patients was granted based on the results of...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Diagnostyka i leczenie post ępującej wieloogniskowej leukoencefalopatii
Publication date: September 2015 Source:Acta Haematologica Polonica, Volume 46, Issue 4 Author(s): Monika Kulma-Kreft, Krzysztof Leśniewski-Kmak, Jan Maciej Zaucha Progressive multifocal leukoencephalopathy (PML) is a rare but a very serious complication associated inter alia with the use of new biological and immunomodulatory agents that cause long-lasting immunosuppression. This also applies to rituximab, commonly used for treatment of B-cell non-Hodgkin lymphoma (NHL) patients. PML may develop during, as well as after, completion of treatment with rituximab. Diagnosis of PML is not easy and poses a significan...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Pierwotny ch łoniak ośrodkowego układu nerwowego u pacjentów immunokompetentnych
Publication date: September 2015 Source:Acta Haematologica Polonica, Volume 46, Issue 4 Author(s): Edyta Ponikowska-Szyba Primary central nervous system lymphoma (PCNSL) is a rare malignancy, exclusively arising in central nervous system (CNS) and in the intraocular compartment, accounting for 4% of all intracranial tumors. Recently, the incidence of PCNSL is progressively increasing in immunocompetent patients and in the elderly age group. CNS involvement and diffuse large B cell lymphoma (DLBCL) histology in 95% of cases are responsible for an aggressive clinical course of this malignancy. Particular microenvironme...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Ch łoniaki agresywne z komórek B z podwójną/potrójną translokacją – double/triple hit lymphoma
Publication date: September 2015 Source:Acta Haematologica Polonica, Volume 46, Issue 4 Author(s): Jan Walewski Large B-cell lymphoma with cytogenetically detected rearrangement and/or increased copy number of MYC, BCL2, and/or BCL6 are frequently termed double/triple hit lymphoma (DHL/THL) due to molecular, biologic, and clinical similarities. In particular, patient outcome after standard therapy is disappointing; there is a high risk of central nervous system involvement, and resistance to second-line treatment in case of recurrent or progressive disease. DHL/THL are not recognized as a separate diagnostic entity, ...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Analiza leczenia nawrotowych i opornych postaci szpiczaka plazmocytowego w śród polskich pacjentów
This study summarizes therapeutic strategies used to treat recurrent plasma cell myeloma in Polish population before 2015, when bortezomib has become available in the first-line therapy. We focused mainly on the use of IMiDs and proteasome inhibitors. To analyze the situation medical records of patients treated in 21 Polish hematological centers have been reviewed. In total data on 400 patients were analyzed and extrapolated to the national level to obtain data on 7293 patients (400/7293). Mean number of applied therapies was 1.7. Half of the patients were treated with two or more chemotherapy regimens. Second-line therapy...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Wykrywanie mutacji inwersyjnych (INV22 oraz INV1) w genie F8 metod ą IS-PCR u polskich chorych na ciężką hemofilię A
Publication date: November 2015 Source:Acta Haematologica Polonica, Volume 46, Issue 5 Author(s): Edyta Odnoczko, Ewa Stefańska-Windyga, Beata Baran, Magdalena Górska-Kosicka, Joanna Sowińska, Ksenia Bykowska, Jerzy Windyga Hemophilia A is a genetically determined bleeding disorder, caused by deficiency, lack or dysfunction of plasma coagulation factor VIII. Approximately in 45–50% of severe haemophilia A patients excessive bleeding tendency is caused by the occurrence of inversion mutation in the intron 22 (INV22) F8 gene and in about 1–5% – inversion mutation in the intron 1 (INV1). In this pap...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Monoklonalne przeciwcia ła w szpiczaku plazmocytowym – przełom w terapii
Publication date: November 2015 Source:Acta Haematologica Polonica, Volume 46, Issue 5 Author(s): Magdalena Olszewska-Szopa, Artur Jurczyszyn Myeloma multiplex (MM) is one of the most common haematological malignancies. In recent years, due to new drugs introduction, overall survival of the patients has improved very much. Nevertheless new active ingredients are being searched. There is growing attention to monoclonal antibodies. Over 20 molecules are being investigated, but none of them has already been approved in MM. Work on elotuzumab, daratumumab and in bone disease on denosumab is the most advanced. In this a...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Limfohistiocytoza hemofagocytarna zwi ązana z infekcją – opis przypadku
Publication date: January–March 2016 Source:Acta Haematologica Polonica, Volume 47, Issue 1 Author(s): Karolina Torba, Grzegorz Helbig, Krzysztof Woźniczka, Anna Wacławik, Sławomira Kyrcz-Krzemień Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disorder characterized by abnormal activation of macrophages. It is also characterized by hemophagocytosis in the bone marrow and in the reticuloendothelial system (RES). The most common symptoms are persistent fever, splenomegaly and cytopenia. The probable mechanism of disease is due to hyperinflammation caused by increasing amounts of ...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Alloprzeciwcia ła odpornościowe anty-C po transplantacji krwiotwórczych komórek macierzystych
Publication date: January–March 2016 Source:Acta Haematologica Polonica, Volume 47, Issue 1 Author(s): Lucyna Pawelec-Marzec, Małgorzata Szymczyk-Nużka After multiple transfusions of blood components the patient produced alloantibodies anti-C from the Rh blood group system. These antibodies were the reason of the lack of compatibility of red blood cells of donor's hematopoietic stem cells. After allogeneic hematopoietic stem cell transplantation (allo-HSCT) the presence of anti-C from the Rh group was observed, which may indicate production of these antibodies by residual donor lymphocytes. The presence of anti...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Przyczyny dyskwalifikacji niespokrewnionych dawc ów krwiotwórczych komórek macierzystych
Conclusion The percentages of permanent deferrals are low in Polish donors. The temporal deferrals are mostly based on suspicion of infectious diseases. The temporal deferrals of over 3 weeks in most of the cases effectively block the donation possibility. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Zmiany bia łaczkowe w ośrodkowym układzie nerwowym w przebiegu przewlekłej białaczki limfocytowej
Publication date: January–March 2016 Source:Acta Haematologica Polonica, Volume 47, Issue 1 Author(s): Ewa Wąsik-Szczepanek, Dariusz Szczepanek, Małgorzata Wach, Marek Hus Central nervous system involvement (CNS) of chronic lymphocytic leukemia (CLL) is a rare complication. Some analyses of autopsy studies suggest that the complication remains subclinical or is under-diagnosed. The symptoms of patients with leukemic CNS involvement are heterogeneous and nonspecific. Due to the low incidence, there are no treatment guidelines for this problem. Intrathecal chemotherapy and cranial irradiation are often perfor...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
Wczesna diagnostyka i leczenie postaci opornych i nawrotowych klasycznego ch łoniaka Hodgkina
Publication date: January–March 2016 Source:Acta Haematologica Polonica, Volume 47, Issue 1 Author(s): Jan Maciej Zaucha, Andrzej Deptała, Renata Zaucha Although the prognosis of Hodgkin's lymphoma (HL) is relatively good, about 10% of patients with early and up to 30% with advanced stages do not respond to first line treatment (ABVD) or relapse. The chemoresistance is defined as: the progression of the disease during treatment, lack of complete metabolic response during or after treatment, or the very early <3 months) relapse. At the time of relapse patients can be assigned to three risk groups: high, ...
Source: Acta Haematologica Polonica - July 20, 2016 Category: Hematology Source Type: research
