Biosimilars: An update on clinical trials (review of published and ongoing studies)
Biosimilars represent a new trend in the treatment of many immune-mediated inflammatory diseases. Regulatory requirements for approval of biosimilars are different from those of originators and rely mostly on the evidence generated from bioequivalence studies and in particular from RCTs. Our goal in this review was to search for relevant studies from randomized controlled trials on the biosimilars adalimumab, etanercept, infliximab and ustekinumab compared with their reference medication (publication in Medline) and ongoing studies in clinical trial registries. For infliximab biosimilars, we found data on patients with ank...
Source: Acta Dermatovenerologica Croatica - May 5, 2017 Category: Dermatology Source Type: research
Aging – what do we know?
Skin aging is a combination of reduction in the biological activity of cells, a slowing down of regenerative processes, and a loss of resistance to environmental factors. Genetics, lifestyle, and hormones significantly affect proper functioning of the skin. The aim of this article was to present the current knowledge about aging processes and concurrent therapies which can influence skin aging. (Source: Acta Dermatovenerologica Croatica)
Source: Acta Dermatovenerologica Croatica - May 5, 2017 Category: Dermatology Source Type: research
The prevalence of penile pearly papules among young men
The aim of this study was to determine the prevalence of pearly penile papules (PPP) among young men in Eskisehir, Turkey. This was a prospective, non-randomized, cross-sectional study. From December 2014 to September 2015, 2613 consecutive male patients who were referred to the dermatology outpatient clinic were included in the study. Patients were inspected for the presence of PPP, localization, and association with human papilloma virus (HPV). A total of 2613 patients were included in the study.The average age of the patients was 21.33 ±2.08 (mean ± Standard Deviation (SD); ranging from 18 to 24) years. All of the pat...
Source: Acta Dermatovenerologica Croatica - May 5, 2017 Category: Dermatology Source Type: research
Microinvasive radial growth phase of cutaneous melanoma: a histopathological and immunohistochemical study with diagnostic implications
Cutaneous melanoma (M) can develop through two progression phases: the radial growth phase of M (RGPM) and the vertical one. This distinction has a practical relevance in defining lesions with potential for a metastatic course. We analyzed the morphological attributes (intraepidermal proliferation type, inflammatory infiltrate, mitogenicity, Breslow thickness, Clark level, ulceration) and the immunohistochemical profile (S100, Melan A, HMB45, p16INK4a, CD117, Ki67, Cyclin D1, E Cadherin, Podoplanin) of 12 microinvasive RGPMs in absence of regression, with almost 10 years of follow-up. Immunohistochemistry (IHC) revealed th...
Source: Acta Dermatovenerologica Croatica - May 5, 2017 Category: Dermatology Source Type: research
Stress and coping in patients with clinical manifestation of Human papillomavirus
This study was based on patients with clinical manifestations of human papillomavirus (HPV) infection and a control group of patients with psoriasis who were admitted over a period of one year to the Dermatology Department of Karlovac General Hospital. A total of 122 patients participated in the study, either with a confirmed diagnosis of clinical manifestations of HPV infection (n=66) or in a psoriasis control group (n=56). The aim of this study was to determine which coping strategies are used in patients with clinical manifestations of HPV infection. We used the Recent Life Changes Questionnaire and Brief COPE test for ...
Source: Acta Dermatovenerologica Croatica - May 5, 2017 Category: Dermatology Source Type: research
Red blood cell distribution width is a reliable marker of inflammation in plaque psoriasis
Psoriasis is a systemic inflammatory disease accepted as an independent risk factor for cardiovascular diseases (CVD). Elevated levels and correlation of red cell distribution width (RDW) with inflammatory markers has recently been shown in studies investigating CVD risk and prognosis in rheumatoid arthritis and ankylosing spondylitis. The aim of this study was to evaluate levels and correlation of RDW with inflammatory markers in patients with plaque psoriasis. Data including demographics, disease severity indices, laboratory parameters, and bioelectrical impedance analysis was collected from medical charts of patients wh...
Source: Acta Dermatovenerologica Croatica - May 5, 2017 Category: Dermatology Source Type: research
Two ultrasonographic patterns in maculopapular cutaneous mastocytosis: a preliminary report
We present 2 characteristic ultrasonographic patterns of MPCM lesions. Three subjects presented with an abnormal, widened, and hypoechogenic area representing the dermis. One subject demonstrated an anechogenic fusiform structure below the epidermis that represented a localized pattern of infiltrate. This patient responded better to psoralen and ultraviolet A radiation (PUVA) therapy than the other subjects. Our research implies that HFUS may be used as an additional method in evaluating skin lesions in MPCM. (Source: Acta Dermatovenerologica Croatica)
Source: Acta Dermatovenerologica Croatica - May 5, 2017 Category: Dermatology Source Type: research
Lupus band test in patients with borderline systemic lupus erythematosus patients with discoid lesions
Patients with lupus erythematosus (LE) that have discoid lesions who fulfill the four diagnostic criteria of systemic lupus erythematosus (SLE) with only mucocutaneous findings and antinuclear antibody (ANA) positivity were classified as borderline SLE in the literature. Objective of this study was to determine the place of borderline SLE with discoid lesions on the LE spectrum according to the lupus band test (LBT). Lesional and sun-protected non-lesional (SPNL) skin LBTs of 94 patients with LE that had discoid lesions were retrospectively evaluated. Firstly, patients were divided into two main groups: discoid LE (DLE; gr...
Source: Acta Dermatovenerologica Croatica - May 5, 2017 Category: Dermatology Source Type: research
Correlation of antibodies against desmogleins 1 and 3 with indirect immunofluorescence and disease activity in 72 patients with pemphigus vulgaris
This study supports the previous observations that the disease severity in most patients with pemphigus correlates with IIF titers, which in turn is determined by the quantities of Dsg1 and Dsg3 antibodies, as well as the previous observation that the clinical phenotype and antibody profile are n ot always in correlation. (Source: Acta Dermatovenerologica Croatica)
Source: Acta Dermatovenerologica Croatica - May 5, 2017 Category: Dermatology Source Type: research
Health and economic burden of skin melanoma in Croatia – cost-of-illness study
Melanoma incidence is increasing, especially in the younger population. The aim of this study was to investigate the cost of this disease in the Croatian population and to identify costs through types of care and types of costs. The secondary goal was to estimate the prevalence of certain types of melanoma (as well as staging distribution) and to connect each stage and its prevalence in Croatia to related costs. A cost-of-illness analysis was performed, mainly including direct costs (monitoring, drugs, primary health care services, hospitalizations, and diagnostics). The calculations were based on data collected from Sestr...
Source: Acta Dermatovenerologica Croatica - May 5, 2017 Category: Dermatology Source Type: research
Adc 24(4)
(Source: Acta Dermatovenerologica Croatica)
Source: Acta Dermatovenerologica Croatica - January 30, 2017 Category: Dermatology Source Type: research
Thin Melanoma: a Generic Term Including Four Histological Subtypes of Cutaneous Melanoma
No abstract available (Source: Acta Dermatovenerologica Croatica)
Source: Acta Dermatovenerologica Croatica - January 28, 2017 Category: Dermatology Source Type: research
Gestational Pityriasis Rosea: Suggestions for Approaching Affected Pregnant Women
(Source: Acta Dermatovenerologica Croatica)
Source: Acta Dermatovenerologica Croatica - January 28, 2017 Category: Dermatology Source Type: research
Direct Insertion of Muscle Fibers is not Restricted to Facial Muscles
(Source: Acta Dermatovenerologica Croatica)
Source: Acta Dermatovenerologica Croatica - January 28, 2017 Category: Dermatology Source Type: research
Vesicular Contact Reaction May Progress into Erythema Multiforme
No abstract available (Source: Acta Dermatovenerologica Croatica)
Source: Acta Dermatovenerologica Croatica - January 28, 2017 Category: Dermatology Source Type: research
