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Xenotransplantation, Ahead of Print. (Source: Xenotransplantation)
Source: Xenotransplantation - January 23, 2018 Category: Transplant Surgery Source Type: research
The value of glycated albumin for the prediction of graft outcome in the non ‐human primate porcine islet transplantation model
ConclusionsAs a surrogate indicator for graft function, serial measurement of GA may provide Supporting Information to that obtained from conventional monitoring techniques of graft function for assessing porcine islet grafts in NHP models. (Source: Xenotransplantation)
Source: Xenotransplantation - January 23, 2018 Category: Transplant Surgery Authors: Hee Jung Kang, Haneulnari Lee, Eun Mi Park, Jong ‐Min Kim, Jun‐Seop Shin, Chung‐Gyu Park Tags: ORIGINAL ARTICLE Source Type: research
Does size matter?
(Source: Xenotransplantation)
Source: Xenotransplantation - January 23, 2018 Category: Transplant Surgery Authors: Joachim Denner, Bruno Reichart, Matthias L ängin Tags: LETTER TO THE EDITOR Source Type: research
Strong xenoprotective function by single ‐copy transgenes placed sequentially at a permissive locus
ConclusionStep‐by‐step placement enables highly expressed single‐copy xenoprotective transgenes to be grouped at porcine ROSA26. (Source: Xenotransplantation)
Source: Xenotransplantation - January 23, 2018 Category: Transplant Surgery Authors: Beate Rieblinger, Konrad Fischer, Alexander Kind, Benedikt S. Saller, Wiebke Baars, Marion Schuster, Lelia Wolf ‐van Buerck, Andrea Schäffler, Tatiana Flisikowska, Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Krzysztof Flisikowski, Eckhard Wol Tags: ORIGINAL ARTICLE Source Type: research
Effect of an oxygen ‐generating scaffold on the viability and insulin secretion function of porcine neonatal pancreatic cell clusters
Xenotransplantation, EarlyView. (Source: Xenotransplantation)
Source: Xenotransplantation - January 10, 2018 Category: Transplant Surgery Source Type: research
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Xenotransplantation, Ahead of Print. (Source: Xenotransplantation)
Source: Xenotransplantation - January 10, 2018 Category: Transplant Surgery Source Type: research
Multiple genetically modified GTKO/hCD46/HLA ‐E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood
ConclusionGTKO, hCD46, and HLA‐E expression in porcine hearts reduced complement deposition, complement dependent injury, and myocardial NK cell infiltration during perfusion with human blood. This tested combination of genetic modifications may minimize damage from acute human‐anti‐pig rejection reactions and improve myocardial function after xenotransplantation. (Source: Xenotransplantation)
Source: Xenotransplantation - January 1, 2018 Category: Transplant Surgery Authors: Jan ‐Michael Abicht, Riccardo Sfriso, Bruno Reichart, Matthias Längin, Katja Gahle, Gisella L. Puga Yung, Jörg D. Seebach, Robert Rieben, David Ayares, Eckhard Wolf, Nikolai Klymiuk, Andrea Baehr, Alexander Kind, Tanja Mayr, Andreas Bauer Tags: ORIGINAL ARTICLE Source Type: research
GalT ‐KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels
ConclusionsTo our knowledge, this is the first evidence of histologically viable porcine lung grafts beyond 7 days in baboons. Our results indicate that GalT‐KO pig lungs are highly susceptible to acute humoral rejection and that this may be mitigated by transgenic expression of hCD47. (Source: Xenotransplantation)
Source: Xenotransplantation - January 1, 2018 Category: Transplant Surgery Authors: Hironosuke Watanabe, Hisashi Sahara, Shunichiro Nomura, Tatsu Tanabe, Dilrukshi K. Ekanayake ‐Alper, Lennan K. Boyd, Nathan J. Louras, Arsenoi Asfour, Makenzie A. Danton, Siu‐Hong Ho, Scott J. Arn, Robert J. Hawley, Akira Shimizu, Takeshi Nagayasu, Da Tags: ORIGINAL ARTICLE Source Type: research
Pigs expressing the human inhibitory ligand PD ‐L1 (CD 274) provide a new source of xenogeneic cells and tissues with low immunogenic properties
ConclusionsThese data indicate a low immunogenic, immune‐protected status of cells from hPD‐L1 transgenic pigs. The integration of the hPD‐L1 concept into existing multi‐transgenic pigs is promising to achieve long‐term survival of porcine xenografts in non‐human primate recipients. (Source: Xenotransplantation)
Source: Xenotransplantation - January 1, 2018 Category: Transplant Surgery Authors: Anna Buermann, Stoyan Petkov, Bj örn Petersen, Rabea Hein, Andrea Lucas‐Hahn, Wiebke Baars, Antje Brinkmann, Heiner Niemann, Reinhard Schwinzer Tags: ORIGINAL ARTICLE Source Type: research
Comparison of detergent ‐based decellularization protocols for the removal of antigenic cellular components in porcine aortic valve
ConclusionsThese results indicated that SDS‐based protocols more effectively removed antigenic cellular components compared to Triton X‐100‐based protocols. These results are clinically significant because complete removal of antigenic determinants is critical to decrease adverse immune‐mediated and inflammatory responses to a PAV when used in xenogeneic application.
Schematic depiction of detergent‐based decellularization protocols for the removal of antigenic cellular components from PAVs. (Source: Xenotransplantation)
Source: Xenotransplantation - January 1, 2018 Category: Transplant Surgery Authors: Xiaohong Liu, Ning Li, Dejun Gong, Cuiping Xia, Zhiyun Xu Tags: ORIGINAL ARTICLE Source Type: research
The Sda and Cad glycan antigens and their glycosyltransferase, β1,4GalNAcT‐II, in xenotransplantation
Abstract
Antibody‐mediated rejection is a barrier to the clinical application of xenotransplantation, and xenoantigens play an important role in this process. Early research suggested that N‐acetyl‐D‐galactosamine (GalNAc) could serve as a potential xenoantigen. GalNAc is the immunodominant glycan of the Sda antigen. Recently, knockout of β1,4‐N‐acetylgalactosaminyltransferase 2 (β1,4GalNAcT‐II) from the pig results in a decrease in binding of human serum antibodies to pig cells. It is believed that this is the result of the elimination of the GalNAc on the Sda antigen, which is catalyzed by the enzyme, β1...
Source: Xenotransplantation - January 1, 2018 Category: Transplant Surgery Authors: Chengjiang Zhao, David K. C. Cooper, Yifan Dai, Hidetaka Hara, Zhiming Cai, Lisha Mou Tags: REVIEW ARTICLE Source Type: research
Interleukin ‐8 mediates neutrophil‐endothelial interactions in pig‐to‐human xenogeneic models
ConclusionsPig IL‐8 increased in an ex vivo model of pig‐to‐human lung xenotransplantation but is not detected in vivo, whereas human or NHP IL‐8 is elevated to a similar degree in both models. Both pig and human IL‐8 activate human neutrophils and increase their adhesion to pig aortic ECs, a process significantly inhibited by the addition of Reparixin to human neutrophils. This work implicates IL‐8, whether of pig or human origin, as a possible factor mediating in lung xenograft inflammation and injury and supports the evaluation of therapeutic targeting of this pathway in the context of xenotransplantation. (...
Source: Xenotransplantation - January 1, 2018 Category: Transplant Surgery Authors: Beth M. French, Selin Sendil, Krishna Mohan Sepuru, Jolene Ranek, Lars Burdorf, Donald Harris, Emily Redding, Xiangfei Cheng, Christopher T. Laird, Yuming Zhao, Benjamin Cerel, Krishna Rajarathnam, Richard N. Pierson, Agnes M. Azimzadeh Tags: ORIGINAL ARTICLE Source Type: research
