---
Xenotransplantation,Volume 25, Issue 1, January/February 2018. (Source: Xenotransplantation)
Source: Xenotransplantation - November 12, 2017 Category: Transplant Surgery Source Type: research
The Natural Anti ‐Gal Antibody as Foe Turned Friend in MedicineUri GaliliPhD, Academic Press (an imprint of Elsevier), London, 2018. pp. 1‐300. Price US$95.50.
(Source: Xenotransplantation)
Source: Xenotransplantation - November 12, 2017 Category: Transplant Surgery Authors: David K. C. Cooper Tags: BOOK REVIEW Source Type: research
Culturing with modified EGM2 medium enhances porcine neonatal islet ‐like cell clusters resistance to apoptosis in islet xenotransplantation
ConclusionCulturing NICC with EGM2 provides a simple and effective approach not only to increase NICC yield, viability, and maturation but also to enhance their resistance to apoptosis to preserve the initial graft mass for successful islet xenotransplantation. (Source: Xenotransplantation)
Source: Xenotransplantation - November 12, 2017 Category: Transplant Surgery Authors: Xiaoqian Ma, Cejun Yang, Juan Zhang, Jia Wang, Wei Li, Chang Xu, Pengfei Rong, Bin Ye, Minghua Wu, Jianhui Jiang, Shounan Yi, Wei Wang Tags: ORIGINAL ARTICLE Source Type: research
The effect of epitope ‐based ligation of ICAM‐1 on survival and retransplantation of pig islets in nonhuman primates
ConclusionsLong‐term survival of pig islet xenografts and successful retransplantation were achieved with MD‐3 mAb‐based immunosuppression regimen in this pig‐to‐monkey transplantation model. It should be emphasized that these encouraging results were achieved following the transplantation of islets from pigs that had not been genetically modified. Considering that it is possible to further substantially reduce the destruction of grafted islet using genetically modified pig islet, the islet requirement could be reduced and much longer graft survival can be achieved. (Source: Xenotransplantation)
Source: Xenotransplantation - November 12, 2017 Category: Transplant Surgery Authors: Jae ‐Il Lee, Jiyeon Kim, Yun‐Jung Choi, Hi‐Jung Park, Hye‐Jin Park, Hae Joo Wi, Sunok Yoon, Jun‐Seop Shin, Jin Kyun Park, Kyeong Cheon Jung, Eun Bong Lee, Hee Jung Kang, Eung Soo Hwang, Sang‐Joon Kim, Chung‐Gyu Park, Seong Hoe Park Tags: ORIGINAL ARTICLE Source Type: research
P ‐ and E‐selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage
ConclusionsSelectin blockade may be useful as part of an integrated strategy to prevent neutrophil‐mediated organ xenograft injury, especially during the early time points following reperfusion. (Source: Xenotransplantation)
Source: Xenotransplantation - November 1, 2017 Category: Transplant Surgery Authors: Christopher T. Laird, Wessam Hassanein, Natalie A. O'Neill, Beth M. French, Xiangfei Cheng, William E. Fogler, John L. Magnani, Dawn Parsell, Arielle Cimeno, Carol J. Phelps, David Ayares, Lars Burdorf, Agnes M. Azimzadeh, Richard N. Pierson Tags: ORIGINAL ARTICLE Source Type: research
Effect of an oxygen ‐generating scaffold on the viability and insulin secretion function of porcine neonatal pancreatic cell clusters
ConclusionsNPCCs in PDMS + CaO2 scaffolds show higher viability and insulin secretion than do NPCCs in PDMS scaffolds and control cells. Therefore, this oxygen‐generating scaffold has potential for application in future islet transplantation studies. (Source: Xenotransplantation)
Source: Xenotransplantation - November 1, 2017 Category: Transplant Surgery Authors: Eun Mi Lee, Ji ‐In Jung, Zahid Alam, Hee‐Gyeong Yi, Heejin Kim, Jin Woo Choi, Sunghoon Hurh, Young June Kim, Jong Cheol Jeong, Jaeseok Yang, Kook‐Hwan Oh, Hee Chan Kim, Byeong Chun Lee, Inho Choi, Dong‐Woo Cho, Curie Ahn Tags: ORIGINAL ARTICLE Source Type: research
CD4+CD25HiFoxP3+ regulatory T cells in long ‐term cardiac xenotransplantation
ConclusionOur results suggest that regulatory T (Treg) cells may contribute to preventing or delaying xenograft rejection by controlling the activation and expansion of donor‐reactive T cells, thereby masking the antidonor immune response, leading to long‐term survival of cardiac xenografts. (Source: Xenotransplantation)
Source: Xenotransplantation - November 1, 2017 Category: Transplant Surgery Authors: Avneesh K. Singh, Joshua L. Chan, Caleb N. Seavey, Philip C. Corcoran, Robert F. Hoyt, Billeta G.T. Lewis, Marvin L. Thomas, David L. Ayares, Keith A. Horvath, Muhammad M. Mohiuddin Tags: ORIGINAL ARTICLE Source Type: research
Examining the potential for porcine ‐derived islet cells to harbour viral pathogens
In this study, we wished to investigate whether islet cells indeed harboured the same viral pathogens of concern in the source animal. PMBC and islet cells from both adult and neonatal source animals were directly compared and tested for PCMV, PLHV, PCV2, PPV and HEV using both molecular and serological assays. Adult PBMC were found positive for all viruses with the exception of PCV2 and HEV. Neonatal PBMC were only found positive for PCMV and HEV. All animals were found negative for HEV antibodies. Interestingly, islet cells were negative for all viruses tested regardless of status in the animal‐derived PBMC. Given that...
Source: Xenotransplantation - November 1, 2017 Category: Transplant Surgery Authors: Claire Crossan, Zoe O'Hara, Nizar Mourad, Pierre Gianello, Linda Scobie Tags: BRIEF COMMUNICATION Source Type: research
Delayed revascularization of islets after transplantation by IL ‐6 blockade in pig to non‐human primate islet xenotransplantation model
ConclusionsOur results demonstrated that tocilizumab can delay revascularization of the transplanted islet, although this effect had no significant correlation to the overall islet graft survival. In the pig to NHP islet xenotransplantation model, the endothelial cells from recipient monkey form new blood vessels in and around pig islets. (Source: Xenotransplantation)
Source: Xenotransplantation - November 1, 2017 Category: Transplant Surgery Authors: Byoung ‐Hoon Min, Jun‐Seop Shin, Jong‐Min Kim, Seong‐Jun Kang, Hyun‐Je Kim, Il‐Hee Yoon, Su‐Kyoung Park, Ji‐won Choi, Min‐Suk Lee, Chung‐Gyu Park Tags: ORIGINAL ARTICLE Source Type: research
Effects of carbon monoxide on early dysfunction and microangiopathy following GalT ‐KO porcine pulmonary xenotransplantation in cynomolgus monkeys
Xenotransplantation,Volume 25, Issue 1, January/February 2018. (Source: Xenotransplantation)
Source: Xenotransplantation - October 25, 2017 Category: Transplant Surgery Source Type: research
Synthetic liver function is detectable in transgenic porcine livers perfused with human blood
Xenotransplantation,Volume 25, Issue 1, January/February 2018. (Source: Xenotransplantation)
Source: Xenotransplantation - October 25, 2017 Category: Transplant Surgery Source Type: research
---
Xenotransplantation,Volume 25, Issue 1, January/February 2018. (Source: Xenotransplantation)
Source: Xenotransplantation - October 25, 2017 Category: Transplant Surgery Source Type: research
