Aldehyde dehydrogenase 1 a1 regulates energy metabolism in adipocytes from different species
ConclusionsOur data demonstrate the functional exchange of regulatory factors between adipocytes from different species for regulation of energy balance. RBP4 and LCN2 appear to be involved in the transport of retinoids for regulation of lipid accumulation and thermogenesis in xenocultures. While the rarity of thermogenic adipocytes in humans and dogs precludes their use for autologous transplantation, our study demonstrates that xenotransplantation of engineered cells could be a potential solution for the reduction in obesity in dogs and a strategy for translation to patients. (Source: Xenotransplantation)
Source: Xenotransplantation - May 1, 2017 Category: Transplant Surgery Authors: Kefeng Yang, Christopher Adin, Qiwen Shen, Ly James Lee, Lianbo Yu, Paolo Fadda, Arpad Samogyi, Kathleen Ham, Lu Xu, Chen Gilor, Ouliana Ziouzenkova Tags: ORIGINAL ARTICLE Source Type: research
Cytokine profiles in Tibetan macaques following α‐1,3‐galactosyltransferase‐knockout pig liver xenotransplantation
ConclusionHere, we established a modified auxiliary liver xenotransplantation model resulting in near‐normal hepatic function. Inflammatory cytokines might contribute to early damage in liver xenografts. Controlling the systemic inflammatory response of recipients might prevent early post‐Tx graft dysfunction. (Source: Xenotransplantation)
Source: Xenotransplantation - May 1, 2017 Category: Transplant Surgery Authors: Zhuochao Zhang, Xiao Li, Hong Zhang, Xuan Zhang, Hui Chen, Dengke Pan, Hongchen Ji, Liang Zhou, Juan Ling, Jingshi Zhou, Shuqiang Yue, Desheng Wang, Zhaoxu Yang, Kaishan Tao, Kefeng Dou Tags: ORIGINAL ARTICLE Source Type: research
Newspaper coverage of human ‐pig chimera research: A qualitative study on select media coverage of scientific breakthrough
ConclusionsOur results appeared to align with similar research performed on the media representation of sensitive scientific news coverage. We also explored the inconsistency between the tone of the titles and the articles that followed. However, it is still too early to speculate what impact the media will play in the public perception of this particular research. (Source: Xenotransplantation)
Source: Xenotransplantation - May 1, 2017 Category: Transplant Surgery Authors: Abena Hagan ‐Brown, Maddalena Favaretto, Pascal Borry Tags: ORIGINAL ARTICLE Source Type: research
Level of acceptance of islet cell and kidney xenotransplants by personnel of hospitals with and without experience in clinical xenotransplantation
ConclusionThis study shows that involvement in clinical xenotransplantation trials significantly changes the attitude of the clinical staff towards this technology and suggests that better information given to the society may increase acceptance of the xenotransplantation. (Source: Xenotransplantation)
Source: Xenotransplantation - May 1, 2017 Category: Transplant Surgery Authors: Adrian Abalovich, Shinichi Matsumoto, Carlos J. Wechsler, Mariana E. Carulla, Mart ín E. Siciliano, Daniel Sznaider, Joachim Denner, Robert B. Elliott Tags: ORIGINAL ARTICLE Source Type: research
Sensitive methods and improved screening strategies are needed for the detection of pig viruses
(Source: Xenotransplantation)
Source: Xenotransplantation - April 21, 2017 Category: Transplant Surgery Authors: Joachim Denner Tags: LETTER TO THE EDITOR Source Type: research
Thomas Starzl —Visionary and xenotransplantation pioneer: Commentary from the International Xenotransplant Association Vanguard Committee
(Source: Xenotransplantation)
Source: Xenotransplantation - April 18, 2017 Category: Transplant Surgery Authors: Wayne J. Hawthorne, Arielle Cimeno, Mohamed Ezzelarab, Bynvant Sandhu, Christopher Burlak Tags: COMMENTARY Source Type: research
Early clinical xenotransplantation experiences —An interview with Thomas E. Starzl, MD, PhD
Abstract
Dr Thomas E. Starzl, who died on March 4, 2017, was one of the great pioneers of organ transplantation. He was also a pioneer in the field of xenotransplantation. In 1964, he carried out baboon kidney transplants in six patients with terminal renal disease for whom no living or deceased donor became available; graft survival was for 19‐60 days, the grafts being lost largely through continuous complement activation. Between 1966 and 1974, he carried out one ex vivo liver perfusion and three orthotopic liver transplants using chimpanzees as sources of organs; graft survival was for <14 days. In 1992 and 1993,...
Source: Xenotransplantation - April 18, 2017 Category: Transplant Surgery Authors: David K. C. Cooper Tags: REVIEW ARTICLE Source Type: research
Thomas E. Starzl, MD, PhD, 1926 –2017
(Source: Xenotransplantation)
Source: Xenotransplantation - April 18, 2017 Category: Transplant Surgery Authors: David K.C. Cooper, A. Joseph Tector Tags: IN MEMORIAM Source Type: research
Issue Information
(Source: Xenotransplantation)
Source: Xenotransplantation - April 18, 2017 Category: Transplant Surgery Tags: ISSUE INFORMATION Source Type: research
Improvement of isolated caprine islet survival and functionality in vitro by enhancing of PDX1 gene expression
ConclusionsOur results indicated that supplemented serum‐free medium with tocopherol and IBMX enhances viability and PDX1 gene expression compared to serum‐added and serum‐free media. (Source: Xenotransplantation)
Source: Xenotransplantation - April 11, 2017 Category: Transplant Surgery Authors: Homayoun Hani, Zeenathul Nazariah Allaudin, Mohd ‐Azmi Mohd‐Lila, Kazhal Sarsaifi, Mina Rasouli, Yew Joon Tam, Tengku‐Azmi Tengku‐Ibrahim, Abas Mazni Othman Tags: ORIGINAL ARTICLE Source Type: research
The potentiating effect of hTFPI in the presence of hCD47 reduces the cytotoxicity of human macrophages
ConclusionsWhen hCD47 was expressed, the expression of hTFPI leaded to tyrosine phosphorylation of SIRP‐α in activated THP‐1 cells via hTSP‐1 inhibition, and consequently, it might improve the effect of hCD47‐SIRP‐a signaling. (Source: Xenotransplantation)
Source: Xenotransplantation - April 10, 2017 Category: Transplant Surgery Authors: Sung Han Jung, Jeong Ho Hwang, Sang Eun Kim, Kim Young Kyu, Hyo Chang Park, Hoon Taek Lee Tags: ORIGINAL ARTICLE Source Type: research
Anti ‐CD40 antibody‐mediated costimulation blockade promotes long‐term survival of deep‐lamellar porcine corneal grafts in non‐human primates
ConclusionsAn anti‐CD40 antibody‐mediated blockade appears to be effective immunosuppressive approach for porcine corneal deep‐lamellar xenotransplantation in primates. (Source: Xenotransplantation)
Source: Xenotransplantation - April 10, 2017 Category: Transplant Surgery Authors: Jaeyoung Kim, Dong Hyun Kim, Hyuk Jin Choi, Hyun Ju Lee, Hee Jung Kang, Chung ‐Gyu Park, Eung‐Soo Hwang, Mee Kum Kim, Won Ryang Wee Tags: ORIGINAL ARTICLE Source Type: research
Xenotransplantation literature update, January/February 2017
(Source: Xenotransplantation)
Source: Xenotransplantation - April 6, 2017 Category: Transplant Surgery Authors: Karl Kerns, AnAn Hua, Christopher Burlak Tags: LITERATURE UPDATE Source Type: research
Human IL ‐6, IL‐17, IL‐1β, and TNF‐α differently regulate the expression of pro‐inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells
ConclusionIn conclusion, our data suggest that human IL‐6, IL‐17, IL‐1β, and TNF‐α significantly activate PAECs and are likely to promote inflammation and coagulation reaction in response to xenograft. (Source: Xenotransplantation)
Source: Xenotransplantation - March 16, 2017 Category: Transplant Surgery Authors: Hanchao Gao, Lu Liu, Yanli Zhao, Hidetaka Hara, Pengfei Chen, Jia Xu, Jia Tang, Ling Wei, Zesong Li, David K.C. Cooper, Zhiming Cai, Lisha Mou Tags: ORIGINAL ARTICLE Source Type: research
Hemodynamic and perioperative management in two different preclinical pig ‐to‐baboon cardiac xenotransplantation models
ConclusionIntensive intra‐ and postoperative monitoring and care is required in both transplantation techniques as a requirement for successful weaning from CPB and respirator. After htHTx, the animals needed less catecholamines and were hemodynamically more stable. Even though pulmonary function was often impaired after htHTx, weaning from the respirator and extubation was more successful in this group. (Source: Xenotransplantation)
Source: Xenotransplantation - March 4, 2017 Category: Transplant Surgery Authors: Tanja Mayr, Andreas Bauer, Bruno Reichart, Sonja Guethoff, Uwe Schoenmann, Matthias L ängin, Alessandro Panelli, Alexander Kind, Paolo Brenner, Jan‐Michael Abicht Tags: ORIGINAL ARTICLE Source Type: research
