Xenotransplantation literature update, May –June 2016
(Source: Xenotransplantation)
Source: Xenotransplantation - April 30, 2016 Category: Transplant Surgery Authors: Christopher Burlak Tags: Literature Update Source Type: research
Islet cell transplantation from G öttingen minipigs to cynomolgus monkeys: analysis of virus safety
ConclusionAlthough the donor islet cells and the recipients were negative for HEV using PCR and Western blot analysis, in one recipient, antibodies against HEV were found, indicating infection in a single case. All recipients were negative for antibodies against PERV, and all were negative for PCMV, indicating absence of infection. As HEV was not detected in the donor pig before transplantation, a more complex and regular screening of the animals using highly sensitive methods is required to avoid virus transmission. (Source: Xenotransplantation)
Source: Xenotransplantation - April 30, 2016 Category: Transplant Surgery Authors: Vladimir A. Morozov, Stefan Ludwig, Barbara Ludwig, Avi Rotem, Uriel Barkai, Stefan R. Bornstein, Joachim Denner Tags: Original Article Source Type: research
Islet‐derived damage‐associated molecular pattern molecule contributes to immune responses following microencapsulated neonatal porcine islet xenotransplantation in mice
ConclusionsIn conclusion, early inflammatory reactions might be therapeutic targets for the prolongation of microencapsulated NPIs graft survival. Thus, treatment‐targeting inflammation might improve the efficiency of clinical microencapsulated NPI xenotransplantation. (Source: Xenotransplantation)
Source: Xenotransplantation - April 30, 2016 Category: Transplant Surgery Authors: Takeshi Itoh, Yuko Hata, Hitomi Nishinakamura, Kenjiro Kumano, Hiroyuki Takahashi, Shohta Kodama Tags: Original Article Source Type: research
Is successful orthotopic heart transplantation in the pig‐to‐non‐human primate model required before proceeding to a clinical trial?
(Source: Xenotransplantation)
Source: Xenotransplantation - April 30, 2016 Category: Transplant Surgery Authors: David K. C. Cooper Tags: Letter to the Editor Source Type: research
Jewish ethics and xenotransplantation
ConclusionsJewish ethics has strong tendencies toward supporting xenotransplantation given a certain criteria is met. No categorical bans on xenotransplantation can be established on the grounds of Halacha. (Source: Xenotransplantation)
Source: Xenotransplantation - April 30, 2016 Category: Transplant Surgery Authors: Richard Mathieu Tags: Original Article Source Type: research
Human antibody reactivity against xenogeneic N‐glycolylneuraminic acid and galactose‐α‐1,3‐galactose antigen
ConclusionsWe showed that IgG‐mediated CDC was detected in Neu5Gc‐overexpressed HEK293 cells incubated with human sera; however, this antibody reactivity to Neu5Gc was highly variable among individuals. Our results suggest that additional modifications to the CMAH gene should be considered for widespread use of pig organs for human transplants. (Source: Xenotransplantation)
Source: Xenotransplantation - April 30, 2016 Category: Transplant Surgery Authors: Sunghoon Hurh, Bohae Kang, Inho Choi, Bumrae Cho, Eun Mi Lee, Hwajung Kim, Young June Kim, Yun Shin Chung, Jong Cheol Jeong, Jong‐Ik Hwang, Jae Young Kim, Byeong Chun Lee, Charles D. Surh, Jaeseok Yang, Curie Ahn Tags: Original Article Source Type: research
Issue Information
(Source: Xenotransplantation)
Source: Xenotransplantation - April 30, 2016 Category: Transplant Surgery Tags: Issue Information Source Type: research
Corrigendum
(Source: Xenotransplantation)
Source: Xenotransplantation - April 21, 2016 Category: Transplant Surgery Tags: Corrigendum Source Type: research
Xenotransplantation literature update, January–February 2016
(Source: Xenotransplantation)
Source: Xenotransplantation - April 21, 2016 Category: Transplant Surgery Authors: Christopher Burlak Tags: Literature Update Source Type: research
Issue Information
(Source: Xenotransplantation)
Source: Xenotransplantation - March 11, 2016 Category: Transplant Surgery Tags: Issue Information Source Type: research
First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes—Chapter 2a: source pigs—preventing xenozoonoses
Abstract
Chapter 2 of the original consensus statement published in 2009 by IXA represents an excellent basis for the production of safe donor pigs and pig‐derived materials for porcine islet xenotransplantation. It was intended that the consensus statement was to be reviewed at interval to remain relevant. Indeed, many of the original salient points remain relevant today, especially when porcine islet xenotransplantation is performed in conjunction with immunosuppressants. However, progress in the field including demonstrated safe clinical porcine xenograft studies, increased understanding of risks including those posed...
Source: Xenotransplantation - March 4, 2016 Category: Transplant Surgery Authors: Thomas Spizzo, Joachim Denner, Lawrence Gazda, Michael Martin, Divya Nathu, Linda Scobie, Yasuhiro Takeuchi Tags: Original Article Source Type: research
First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes—Executive summary
Abstract
The International Xenotransplantation Association has updated its original “Consensus Statement on Conditions for Undertaking Clinical Trials of Porcine Islet Products in Type 1 Diabetes,” which was published in Xenotransplantation in 2009. This update is timely and important in light of scientific progress and changes in the regulatory framework pertinent to islet xenotransplantation. Except for the chapter on “informed consent,” which has remained relevant in its 2009 version, all other chapters included in the initial consensus statement have been revised for inclusion in this update. These chapters wil...
Source: Xenotransplantation - March 4, 2016 Category: Transplant Surgery Authors: Bernhard J. Hering, Emanuele Cozzi, Thomas Spizzo, Peter J. Cowan, Gina R. Rayat, David K.C. Cooper, Joachim Denner Tags: Original Article Source Type: research
Pig‐to‐nonhuman primate solid organ xenografting: recent achievements on the road to first‐in‐man explorations
(Source: Xenotransplantation)
Source: Xenotransplantation - February 29, 2016 Category: Transplant Surgery Authors: Henk‐Jan Schuurman Tags: Commentary Source Type: research
Contribution of polymeric materials to progress in xenotransplantation of microencapsulated cells: a review
Abstract
Cell microencapsulation and subsequent transplantation of the microencapsulated cells require multidisciplinary approaches. Physical, chemical, biological, engineering, and medical expertise has to be combined. Several natural and synthetic polymeric materials and different technologies have been reported for the preparation of hydrogels, which are suitable to protect cells by microencapsulation. However, owing to the frequent lack of adequate characterization of the hydrogels and their components as well as incomplete description of the technology, many results of in vitro and in vivo studies appear contradictory...
Source: Xenotransplantation - February 29, 2016 Category: Transplant Surgery Authors: Redouan Mahou, Solène Passemard, Michele Carvello, Alessandra Petrelli, François Noverraz, Sandrine Gerber‐Lemaire, Christine Wandrey Tags: Review Article Source Type: research
Xenotransplantation literature update, March–April 2016
(Source: Xenotransplantation)
Source: Xenotransplantation - February 29, 2016 Category: Transplant Surgery Authors: Christopher Burlak Tags: Literature Update Source Type: research
