Magnetoencapsulated human islets xenotransplanted into swine: a comparison of different transplantation sites
ConclusionWe have demonstrated the feasibility of using a clinical 1.5T MRI to non‐invasively detect the accuracy of APSA magnetocapsule injection into various clinically accessible transplantation sites. Among the investigated transplantation sites, the liver and kidney subcapsular space were found to be the least immuno‐responsive toward xenografted magneto‐encapsulated human islets. (Source: Xenotransplantation)
Source: Xenotransplantation - February 29, 2016 Category: Transplant Surgery Authors: Dian R. Arifin, Steffi Valdeig, Robert A. Anders, Jeff W.M. Bulte, Clifford R. Weiss Tags: Original Article Source Type: research
Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor
ConclusionsThe GPIb‐VWF and GPIIb/IIIa axes play important roles in platelet sequestration and coagulation cascade activation during GalTKO.hCD46 lung xenograft injury. GPIb blockade significantly reduces platelet activation and delays platelet sequestration in this xenolung rejection model, an effect amplified by adding αGPIIb/IIIa blockade or depletion of VWF from pig lung. (Source: Xenotransplantation)
Source: Xenotransplantation - February 29, 2016 Category: Transplant Surgery Authors: Lars Burdorf, Andrea Riner, Elana Rybak, Isabelle I. Salles, Simon F. De Meyer, Aakash Shah, Kevin J. Quinn, Donald Harris, Tianshu Zhang, Dawn Parsell, Franchesca Ali, Evan Schwartz, Elizabeth Kang, Xiangfei Cheng, Evelyn Sievert, Yuming Zhao, Gheorghe B Tags: Original Article Source Type: research
Biophysico‐functional compatibility of Seoul National University (SNU) miniature pig cornea as xenocorneal graft for the use of human clinical trial
ConclusionsIn conclusion, SNU pig cornea is feasible for xenocorneal transplantation using the same preservation protocol as human with respect to biophysical and functional properties and can be stored for up to 7 days for transplantation in human clinical trials. An age limitation of donor pigs may be required for qualified corneal products to be used in human trials. (Source: Xenotransplantation)
Source: Xenotransplantation - February 29, 2016 Category: Transplant Surgery Authors: Dong Hyun Kim, Jaeyoung Kim, Hyun Jeong Jeong, Hyun Ju Lee, Mee Kum Kim, Won Ryang Wee Tags: Original Article Source Type: research
Issue Information
(Source: Xenotransplantation)
Source: Xenotransplantation - February 29, 2016 Category: Transplant Surgery Tags: Issue Information Source Type: research
First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes—Chapter 5: recipient monitoring and response plan for preventing disease transmission
Abstract
Xenotransplantation of porcine cells, tissues, and organs may be associated with the transmission of porcine microorganisms to the human recipient. A previous, 2009, version of this consensus statement focused on strategies to prevent transmission of porcine endogenous retroviruses (PERVs). This version addresses potential transmission of all porcine microorganisms including monitoring of the recipient and provides suggested approaches to the monitoring and prevention of disease transmission. Prior analyses assumed that most microorganisms other than the endogenous retroviruses could be eliminated from donor anima...
Source: Xenotransplantation - February 26, 2016 Category: Transplant Surgery Authors: Joachim Denner, Ralf R. Tönjes, Yasu Takeuchi, Jay Fishman, Linda Scobie Tags: Original Article Source Type: research
