Issue Information
(Source: Stem Cells)
Source: Stem Cells - May 25, 2021 Category: Stem Cells Tags: ISSUE INFORMATION Source Type: research
A preview of select articles
(Source: Stem Cells)
Source: Stem Cells - May 25, 2021 Category: Stem Cells Authors: Stuart P. Atkinson Tags: PREVIEWS Source Type: research
Cover Image
Image depicts the immunomodulatory interactions between mesenchymal stem cells (MSCs) and immune cells. With this powerful immunomodulatory ability, MSCs offer a promising strategy for attenuating COVID-19-related cytokine storm.See Song et al. beginning on page707. (Source: Stem Cells)
Source: Stem Cells - May 25, 2021 Category: Stem Cells Tags: COVER IMAGE Source Type: research
Issue Information
(Source: Stem Cells)
Source: Stem Cells - May 25, 2021 Category: Stem Cells Tags: ISSUE INFORMATION Source Type: research
High ‐mobility group AT‐Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling
This study suggests that HMGA1 plays a role in osteoblast commitment and mediates the function of NFIX through transcriptionally activating canonical Wnt signaling.© AlphaMed Press 2021Significance StatementBone homeostasis depends largely on the number and function of osteoblasts. Osteoblasts and adipocytes are both derived from bone marrow mesenchymal stem cells, and a competitive relationship exists between adipogenesis and osteogenesis. We have identified a novel nuclear factor I/X (NFIX)-high-mobility group AT-Hook 1 (HMGA1)-wingless-type MMTV integration site (Wnt)/ β-catenin regulatory axis that governs the cell f...
Source: Stem Cells - May 24, 2021 Category: Stem Cells Authors: Xiaowen Wu,
Xiaochen Wang,
Liying Shan,
Jie Zhou,
Xin Zhang,
Endong Zhu,
Hairui Yuan,
Baoli Wang Tags: Tissue ‐Specific Stem Cells Source Type: research
Directly Reprogrammed Huntington's Disease Neural Precursor Cells Generate Striatal Neurons Exhibiting Aggregates and Impaired Neuronal Maturation
Directly reprogrammed Huntington's disease induced neural precursor cells generate DARPP32+ striatal neurons exhibiting ubiquitinated huntingtin aggregates, altered neuronal morphologies, reduced hyperpolarisation, and reduced BDNF expression that correlates with age of symptom onset and increased CAG expansion. AbstractHuntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterised by the progressive loss of striatal medium spiny neurons. Using a highly efficient protocol for direct reprogramming of adult human fibroblasts with chemically modified mRNA, we report the first generation of HD indu...
Source: Stem Cells - May 24, 2021 Category: Stem Cells Authors: Ruth Monk,
Kevin Lee,
Kathryn S Jones,
Bronwen Connor Tags: Translational and Clinical Research Source Type: research
Acute myeloid leukemia ‐induced functional inhibition of healthy CD34+ hematopoietic stem and progenitor cells
Acute myeloid leukemia (AML)-induced functional inhibition of healthy CD34+ hematopoietic stem and progenitor cells (HSPC) via secreted factors. In particular transforming growth factor β1 (TGFβ1) plays a role in inhibition of key functions of healthy CD34+ HSPC and blockage of this pathway may serve as therapeutic target to improve hematopoiesis in patients with AML. AbstractAcute myeloid leukemia (AML) is characterized by an expansion of leukemic cells and a simultaneous reduction of normal hematopoietic precursors in the bone marrow (BM) resulting in hematopoietic insufficiency, but the underlying mechanisms are poorl...
Source: Stem Cells - May 20, 2021 Category: Stem Cells Authors: Paul J äger,
Stefanie Geyh,
Sören Twarock,
Ron‐Patrick Cadeddu,
Pablo Rabes,
Annemarie Koch,
Uwe Maus,
Tobias Hesper,
Christoph Zilkens,
Christina Rautenberg,
Felix Bormann,
Karl Köhrer,
Patrick Petzsch,
Dagmar Wieczorek,
Beate Betz,
H Tags: Translational and Clinical Research Source Type: research
miR ‐351‐3p promotes rat amniotic fluid‐derived mesenchymal stromal cell proliferation via targeting the coding sequence of Abca4
From left to right, we show that amniotic fluid (AF) was isolated from pregnant rats, AF-derived mesenchymal stromal cells (AFMSCs) were cultured in the laboratory, highly proliferative AFMSCs were determined, RNA sequencing was conducted, and biological experiments and transcription data were integrated to unveil the regulator of AFMSC proliferation, which was found to be a novel proliferation-related factor. AbstractAmniotic fluid-derived mesenchymal stromal cells (AFMSCs) present different features, depending on the isolation timing and culture conditions. The lack of uniform experimental standards hinders the compariso...
Source: Stem Cells - May 19, 2021 Category: Stem Cells Authors: Jieting Huang,
Qi Zhao,
Xiaowei Wei,
Wei Ma,
Wenting Luo,
Hui Gu,
Dan Liu,
Yiwen He,
Tianchu Huang,
Yusi Liu,
Chenfei Wang,
Zhengwei Yuan Tags: Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics Source Type: research
Radiotherapy and the immune system: More than just immune suppression
The tumor microenvironment, A, can be modulated by radiotherapy (RT) through the induction of immunogenic cell death, B, leading to the priming of cytotoxic T lymphocytes, C. Combinations of RT with immunotherapies, such as immune checkpoint inhibitors counteracting immunosuppression, D, and tumor vaccines or cytokines boosting antitumor immune responses, E, might improve local tumor control and elicit abscopal effects, F. AbstractRadiotherapy (RT) is still one of the standard cancer therapies with up to two third of all cancer patients with solid tumors being irradiated in the course of their disease. The aim of using ion...
Source: Stem Cells - May 18, 2021 Category: Stem Cells Authors: Michael R ückert,
Ann‐Sophie Flohr,
Markus Hecht,
Udo S. Gaipl Tags: Concise Review Source Type: research
Neural stem cells in the adult olfactory bulb core generate mature neurons in vivo
Local neural stem cells (NSCs) contribute to neurogenesis (thick arrows) and gliogenesis (thin arrows) in the adult olfactory bulb. EPL, external plexiform layer; GCL, granule cell layer; GL, glomerular layer; ML, mitral layer. AbstractAlthough previous studies suggest that neural stem cells (NSCs) exist in the adult olfactory bulb (OB), their location, identity, and capacity to generate mature neurons in vivo has been little explored. Here, we injected enhanced green fluorescent protein (EGFP)‐expressing retroviral particles into the OB core of adult mice to label dividing cells and to track the differentiation/matur...
Source: Stem Cells - May 17, 2021 Category: Stem Cells Authors: Çağla Defteralı,
Mireia Moreno‐Estellés,
Carlos Crespo,
Eva Díaz‐Guerra,
María Díaz‐Moreno,
Eva Vergaño‐Vera,
Vanesa Nieto‐Estévez,
Anahí Hurtado‐Chong,
Antonella Consiglio,
Helena Mira,
Carlos Vicario Tags: Tissue ‐Specific Stem Cells Source Type: research
Neural stem cells in the adult olfactory bulb core generate mature neurons in vivo
Local neural stem cells (NSCs) contribute to neurogenesis (thick arrows) and gliogenesis (thin arrows) in the adult olfactory bulb. EPL, external plexiform layer; GCL, granule cell layer; GL, glomerular layer; ML, mitral layer. AbstractAlthough previous studies suggest that neural stem cells (NSCs) exist in the adult olfactory bulb (OB), their location, identity, and capacity to generate mature neurons in vivo has been little explored. Here, we injected enhanced green fluorescent protein (EGFP)-expressing retroviral particles into the OB core of adult mice to label dividing cells and to track the differentiation/maturat...
Source: Stem Cells - May 17, 2021 Category: Stem Cells Authors: Çağla Defteralı,
Mireia Moreno‐Estellés,
Carlos Crespo,
Eva Díaz‐Guerra,
María Díaz‐Moreno,
Eva Vergaño‐Vera,
Vanesa Nieto‐Estévez,
Anahí Hurtado‐Chong,
Antonella Consiglio,
Helena Mira,
Carlos Vicario Tags: Tissue ‐Specific Stem Cells Source Type: research
A case for revisiting Nodal signaling in human pluripotent stem cells
Hayes et al discuss the implications of recent advances in our understanding of Nodal signaling for the maintenance and self ‐renewal of human pluripotent stem cells. AbstractNodal is a transforming growth factor ‐β (TGF‐β) superfamily member that plays a number of critical roles in mammalian embryonic development. Nodal is essential for the support of the peri‐implantation epiblast in the mouse embryo, and subsequently acts to specify mesendodermal fate at the time of gastrulation, and later, left‐ right asymmetry. Maintenance of human pluripotent stem cells (hPSCs) in vitro is dependent on Nodal signaling. ...
Source: Stem Cells - May 10, 2021 Category: Stem Cells Authors: Kevin Hayes,
Yun ‐Kyo Kim,
Martin F. Pera Tags: Concise Review Source Type: research
