ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling
ERG1 binds with Integrin β1 to activate the AKT pathway by recruiting and phosphorylating PI3K p85 and FAK, which promotes rat cardiomyocyte differentiation through mediating phosphorylation of GSK3β to upregulate the expression of both β‐catenin and Gata4, and meanwhile phosphorylating IKKβ to promote nuclear translo cation of nuclear factor‐κB for the inhibition of cell apoptosis. AbstractERG1, a potassium ion channel, is essential for cardiac action potential repolarization phase. However, the role of ERG1 for normal development of the heart is poorly understood. Using the rat embryonic stem cells (rESCs) model...
Source: Stem Cells - February 8, 2021 Category: Stem Cells Authors: Duo Wang,
Chang Liu,
Huan Liu,
Yilei Meng,
Fang Lin,
Yanqiong Gu,
Hanrui Wang,
Mengyue Shang,
Chang Tong,
Agapios Sachinidis,
Qilong Ying,
Li Li,
Luying Peng Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research
A human induced pluripotent stem cell ‐based modular platform to challenge sensorineural hearing loss
Schematic of the various applications of induced pluripotent stem cell (IPSC) modular platform to challenge sensorineural hearing loss. IPSCs can be generated via genetic reprogramming of somatic cells from patient/healthy subject. In the inner ear, this technology has emerged as a promising tool for disease modeling, bioengineering, drug screening/validation and as an otic sensory progenitor source for autologous sensory cell replacement. In the cochlear epithelium, inner hair cells are arranged in a single row and outer hair cells are arranged in three rows (blue color). The supporting cells (yellow color) surround the s...
Source: Stem Cells - February 8, 2021 Category: Stem Cells Authors: Azel Zine,
Yassine Messat,
Bernd Fritzsch Tags: Regenerative Medicine Source Type: research
