Viruses as key modulators of the TGF ‐β pathway; a double‐edged sword involved in cancer
Summary
Transforming growth factor‐β (TGF‐β) signaling pathway is a key network in cell signaling that controls vital processes such as proliferation, differentiation, apoptosis, epithelial‐mesenchymal transition, and migration, thus acting as a double‐edged sword in normal development and diseases, in particular organ fibrosis, vascular disorders, and cancer. Early in tumorigenesis, the pathway exerts anti‐tumor effects through suppressing cell cycle and inducing apoptosis, while during late stages, it functions as a tumor promoter by enhancing tumor invasiveness and metastasis. This signaling pathway can be p...
Source: Reviews in Medical Virology - January 1, 2018 Category: Virology Authors: Habibollah Mirzaei, Ebrahim Faghihloo Tags: REVIEW Source Type: research
Interplay of foot and mouth disease virus with cell ‐mediated and humoral immunity of host
Reviews in Medical Virology,Volume 28, Issue 2, March 2018. (Source: Reviews in Medical Virology)
Source: Reviews in Medical Virology - December 28, 2017 Category: Virology Source Type: research
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Reviews in Medical Virology,Volume 28, Issue 2, March 2018. (Source: Reviews in Medical Virology)
Source: Reviews in Medical Virology - December 28, 2017 Category: Virology Source Type: research
Immunity against hepatitis E virus infection: Implications for therapy and vaccine development
Reviews in Medical Virology,Volume 28, Issue 2, March 2018. (Source: Reviews in Medical Virology)
Source: Reviews in Medical Virology - December 22, 2017 Category: Virology Source Type: research
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Reviews in Medical Virology,Volume 28, Issue 2, March 2018. (Source: Reviews in Medical Virology)
Source: Reviews in Medical Virology - December 22, 2017 Category: Virology Source Type: research
Arboviruses and their related infections in China: A comprehensive field and laboratory investigation over the last 3 decades
Summary
Since the 1980s, a comprehensive field and laboratory investigation has been conducted throughout China, and a total of 29 virus species belonging to 7 families and 13 genera were identified through virological, morphological, and immunological methods, as well as whole‐genome sequencing and molecular genetic analyses. Most of the virus isolates belong to 9 genera in the families Flaviviridae, Bunyaviridae, Togaviridae, and Reoviridae. Among them, 4 genera (Orthobunyavirus, Bunyavirus, Phlebovirus, and Nairovirus) belong to the family Bunyaviridae and 3 genera (Seadonavirus, Orbivirus, and Cypovirus) belong to th...
Source: Reviews in Medical Virology - December 6, 2017 Category: Virology Authors: Guodong Liang, Xiaolong Li, Xiaoyan Gao, Shihong Fu, Huanyu Wang, Minghua Li, Zhi Lu, Wuyang Zhu, Xinjun Lu, Lihua Wang, Yuxi Cao, Ying He, Wenwen Lei Tags: REVIEW Source Type: research
Issue Information
No abstract is available for this article. (Source: Reviews in Medical Virology)
Source: Reviews in Medical Virology - November 20, 2017 Category: Virology Tags: Issue Information Source Type: research
Criteria to define interruption of transmission of human cytomegalovirus from organ donor to recipient
Summary
In this review article, we consider results suggesting that transmission of human cytomegalovirus (HCMV) from a donor of a solid organ to an immunologically naive individual can be reduced. Two randomized controlled trials have been conducted recently, one of active immunization of recipients pretransplant and another of passive immunization with monoclonal antibodies specific for HCMV given at the time of transplant. Although the available data are encouraging—providing evidence of a reduction in the incidence of HCMV viraemia—they fall short of what would be required to prove definitively that transmission ha...
Source: Reviews in Medical Virology - November 17, 2017 Category: Virology Authors: Ilona Anna Baraniak, Matthew B. Reeves, Paul D. Griffiths Tags: REVIEW Source Type: research
Cytomegalovirus is still in intensive care
(Source: Reviews in Medical Virology)
Source: Reviews in Medical Virology - November 15, 2017 Category: Virology Authors: P.D. Griffiths Tags: EDITORIAL Source Type: research
Parainfluenza virus 5 –vectored vaccines against human and animal infectious diseases
Summary
Parainfluenza virus 5 (PIV5), known as canine parainfluenza virus in the veterinary field, is a negative‐sense, nonsegmented, single‐stranded RNA virus belonging to the Paramyxoviridae family. Parainfluenza virus 5 is an excellent viral vector and has been used as a live vaccine for kennel cough for many years in dogs without any safety concern. It can grow to high titers in many cell types, and its genome is stable even in the presence of foreign gene insertions. So far, PIV5 has been used to develop vaccines against influenza virus, respiratory syncytial virus, rabies virus, and Mycobacterium tuberculosis, de...
Source: Reviews in Medical Virology - November 1, 2017 Category: Virology Authors: Zhenhai Chen Tags: REVIEW Source Type: research
Interplay of foot and mouth disease virus with cell ‐mediated and humoral immunity of host
Summary
Foot and mouth disease virus (FMDV) causes a communicable disease of cloven hoofed animals, resulting in major economic losses during disease outbreaks. Like other members of the Picornaviridae FMDV has a relatively short infectious cycle; initiation of infection and dissemination, with production of infectious virions occurs in less than a week. The components of innate immunity as well as cell‐mediated and humoral immunity play a crucial role in control of FMDV. However, it has been shown in vitro using a mouse model that FMDV has evolved certain mechanisms to counteract host immune responses ensuring its survi...
Source: Reviews in Medical Virology - November 1, 2017 Category: Virology Authors: Muhammad Abubakar, Shumaila Manzoor, Afshan Ahmed Tags: REVIEW Source Type: research
Immunity against hepatitis E virus infection: Implications for therapy and vaccine development
Summary
Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide and an emerging cause of chronic infection in immunocompromised patients. As with viral infections in general, immune responses are critical to determine the outcome of HEV infection. Accumulating studies in cell culture, animal models and patients have improved our understanding of HEV immunopathogenesis and informed the development of new antiviral therapies and effective vaccines. In this review, we discuss the recent progress on innate and adaptive immunity in HEV infection, and the implications for the devolopment of effective vacc...
Source: Reviews in Medical Virology - November 1, 2017 Category: Virology Authors: Mohamad S. Hakim, Aqsa Ikram, Jianhua Zhou, Wenshi Wang, Maikel P. Peppelenbosch, Qiuwei Pan Tags: REVIEW Source Type: research
Current status on the development of pseudoviruses for enveloped viruses
Summary
Emerging and reemerging infectious diseases have a strong negative impact on public health. However, because many of these pathogens must be handled in biosafety level, 3 or 4 containment laboratories, research and development of antivirals or vaccines against these diseases are often impeded. Alternative approaches to address this issue have been vigorously pursued, particularly the use of pseudoviruses in place of wild‐type viruses. As pseudoviruses have been deprived of certain gene sequences of the virulent virus, they can be handled in biosafety level 2 laboratories. Importantly, the envelopes of these viral...
Source: Reviews in Medical Virology - November 1, 2017 Category: Virology Authors: Qianqian Li, Qiang Liu, Weijin Huang, Xuguang Li, Youchun Wang Tags: REVIEW Source Type: research
Dengue in Rio Grande do Sul, Brazil: 2014 to 2016
This study analyzes and discusses laboratory, demographic, and clinical data regarding dengue cases in RS, from 2014 to 2016. This study analyzed 13,420 serum samples from notified patients with suspicion of dengue fever in RS from 2014 to 2016. Seasonality of positive cases, viral serotypes, and clinical and epidemiological aspects were analyzed. There was no difference in gender (P = .4); dengue fever occurred mainly in adults, with similar distribution among age groups. The number of dengue virus (DENV) cases increased from 89 cases in 2014 to 2518 in 2016. Dengue virus 1 was the most prevalent circulating serotype du...
Source: Reviews in Medical Virology - November 1, 2017 Category: Virology Authors: Tatiana Schaffer Gregianini, Gabriela Luchiari Tumioto ‐Giannini, Cátia Favreto, Luciana Ciarelli Plentz, Nilo Ikuta, Ana B. Gorini Veiga Tags: REVIEW Source Type: research
Retraction: ‘Ebola virus: an introduction and its pathology’ by Gurpreet Singh, Arbind Kumar, Kashmir Singh and Jagdeep Kaur
(Source: Reviews in Medical Virology)
Source: Reviews in Medical Virology - September 21, 2017 Category: Virology Tags: RETRACTION Source Type: research
