Editorial Board
Publication date: January 2019Source: Progress in Lipid Research, Volume 73Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - January 15, 2019 Category: Lipidology Source Type: research
Phytol metabolism in plants
Publication date: Available online 7 January 2019Source: Progress in Lipid ResearchAuthor(s): Katharina Gutbrod, Jill Romer, Peter DörmannAbstractPhytol, the prenyl side chain of chlorophyll, is derived from geranylgeraniol by reduction of three double bonds. Recent results demonstrated that the conversion of geranylgeraniol to phytol is linked to chlorophyll synthesis, which is catalyzed by protein complexes associated with the thylakoid membranes. One of these complexes contains light harvesting chlorophyll binding like proteins (LIL3), enzymes of chlorophyll synthesis (protoporphyrinogen oxidoreductase, POR; chlorophyl...
Source: Progress in Lipid Research - January 8, 2019 Category: Lipidology Source Type: research
Biochemical studies of membrane fusion at the single-particle level
Publication date: Available online 3 January 2019Source: Progress in Lipid ResearchAuthor(s): Zhiqi Tian, Jihong Gong, Michael Crowe, Ming Lei, Dechang Li, Baohua Ji, Jiajie DiaoAbstractTo study membrane fusion mediated by synaptic proteins, proteoliposomes have been widely used for in vitro ensemble measurements with limited insights into the fusion mechanism. Single-particle techniques have proven to be powerful in overcoming the limitations of traditional ensemble methods. Here, we summarize current single-particle methods in biophysical and biochemical studies of fusion mediated by soluble N-ethylmaleimide-sensitive fa...
Source: Progress in Lipid Research - January 4, 2019 Category: Lipidology Source Type: research
Cholesterol transport system: An integrated cholesterol transport model involved in atherosclerosis
Publication date: Available online 4 December 2018Source: Progress in Lipid ResearchAuthor(s): Xiao-Hua Yu, Da-Wei Zhang, Xi-Long Zheng, Chao-Ke TangAbstractAtherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is removed by the reverse cholesterol transport (RCT) pathway, representing a major antiatherogenic mechanism. In addition to the RCT, other pathways are required for maintaining the whole-body cholesterol homeostasis. Thus, we propose a working model of integrated cholesterol transport, termed t...
Source: Progress in Lipid Research - December 5, 2018 Category: Lipidology Source Type: research
Enzymes of glycerol-3-phosphate pathway in triacylglycerol synthesis in plants: Function, biotechnological application and evolution
Publication date: Available online 4 December 2018Source: Progress in Lipid ResearchAuthor(s): Felipe dos Santos Maraschin, Franceli Rodrigues Kulcheski, Ana Lucia Anversa Segatto, Thomaz Stumpf Trenz, Ossman Barrientos-Diaz, Marcia Margis-Pinheiro, Rogerio Margis, Andreia Carina Turchetto-ZoletAbstractTriacylglycerols (TAG) are the major form of energy storage in plants. TAG are primarily stored in seeds and fruits, but vegetative tissues also possess a high capacity for their synthesis and storage. These storage lipids are essential to plant development, being used in seedling growth during germination, pollen developmen...
Source: Progress in Lipid Research - December 4, 2018 Category: Lipidology Source Type: research
Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies
Publication date: Available online 22 November 2018Source: Progress in Lipid ResearchAuthor(s): Nikhlesh K. Singh, Gadiparthi N. RaoAbstract12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses. The in vitro studies have demonstrated the ability of 12/15-LOX metabolites in the expression of various genes and production of cytokine related to inflammation and resolution of inflammation....
Source: Progress in Lipid Research - November 23, 2018 Category: Lipidology Source Type: research
Plant lipids: Key players of plasma membrane organization and function
Publication date: Available online 19 November 2018Source: Progress in Lipid ResearchAuthor(s): Adiilah Mamode Cassim, Paul Gouguet, Julien Gronnier, Nelson Laurent, Véronique Germain, Magali Grison, Yohann Boutté, Patricia Gerbeau-Pissot, Françoise Simon-Plas, Sébastien MongrandAbstractThe plasma membrane (PM) is the biological membrane that separates the interior of all cells from the outside. The PM is constituted of a huge diversity of proteins and lipids. In this review, we will update the diversity of molecular species of lipids found in plant PM. We will further discuss how lipids govern global properties of the...
Source: Progress in Lipid Research - November 21, 2018 Category: Lipidology Source Type: research
Editorial Board
Publication date: October 2018Source: Progress in Lipid Research, Volume 72Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - November 14, 2018 Category: Lipidology Source Type: research
The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs
Publication date: Available online 17 September 2018Source: Progress in Lipid ResearchAuthor(s): Hartmut Kuhn, Lia Humeniuk, Nikita Kozlov, Sophie Roigas, Susan Adel, Dagmar HeydeckAbstractThe reaction specificity of lipoxygenases (ALOX) impacts the biological activity of these enzymes and also constitutes the decisive parameter for enzyme classification. ALOX15 orthologs, commonly known as 12/15-lipoxygenases, have recently been suggested to exhibit mainly arachidonic acid 12-lipoxygenating specificity in mammals ranked in evolution lower than gibbons and 15-lipoxygenating specificity in the higher ranking primates (Adel ...
Source: Progress in Lipid Research - September 17, 2018 Category: Lipidology Source Type: research
Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology
Publication date: Available online 6 September 2018Source: Progress in Lipid ResearchAuthor(s): Grace E. Lidgerwood, Stuart M. Pitson, Claudine Bonder, Alice PébayAbstractStem cells are unique in their ability to self-renew and differentiate into various cell types. Because of these features, stem cells are key to the formation of organisms and play fundamental roles in tissue regeneration and repair. Mechanisms controlling their fate are thus fundamental to the development and homeostasis of tissues and organs. Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are bioactive phospholipids that play a wide rang...
Source: Progress in Lipid Research - September 7, 2018 Category: Lipidology Source Type: research
Properties, metabolism and roles of sulfogalactosylglycerolipid in male reproduction
Publication date: October 2018Source: Progress in Lipid Research, Volume 72Author(s): Nongnuj Tanphaichitr, Kessiri Kongmanas, Kym F. Faull, Julian Whitelegge, Federica Compostella, Naoko Goto-Inoue, James-Jules Linton, Brendon Doyle, Richard Oko, Hongbin Xu, Luigi Panza, Arpornrad SaewuAbstractSulfogalactosylglycerolipid (SGG, aka seminolipid) is selectively synthesized in high amounts in mammalian testicular germ cells (TGCs). SGG is an ordered lipid and directly involved in cell adhesion. SGG is indispensable for spermatogenesis, a process that greatly depends on interaction between Sertoli cells and TGCs. Spermatogenes...
Source: Progress in Lipid Research - August 31, 2018 Category: Lipidology Source Type: research
Properties, metabolisms and roles of sulfogalactosylglycerolipid in male reproduction
Publication date: Available online 25 August 2018Source: Progress in Lipid ResearchAuthor(s): Nongnuj Tanphaichitr, Kessiri Kongmanas, Kym F. Faull, Julian Whitelegge, Federica Compostella, Naoko Goto-Inoue, James-Jules Linton, Brendon Doyle, Richard Oko, Hongbin Xu, Luigi Panza, Arpornrad SaewuAbstractSulfogalactosylglycerolipid (SGG, aka seminolipid) is selectively synthesized in high amounts in mammalian testicular germ cells (TGCs). SGG is an ordered lipid and directly involved in cell adhesion. SGG is indispensable for spermatogenesis, a process that greatly depends on interaction between Sertoli cells and TGCs. Sperm...
Source: Progress in Lipid Research - August 25, 2018 Category: Lipidology Source Type: research
Lipid storage myopathies: Current treatments and future directions
Publication date: Available online 9 August 2018Source: Progress in Lipid ResearchAuthor(s): Emily R. Vasiljevski, Matthew A. Summers, David G. Little, Aaron SchindelerAbstractLipid storage myopathies (LSMs) are a heterogeneous group of genetic disorders that present with abnormal lipid storage in multiple body organs, typically muscle. Patients can clinically present with cardiomyopathy, skeletal muscle weakness, myalgia, and extreme fatigue. An early diagnosis is crucial, as some LSMs can be managed by simple nutraceutical supplementation. For example, high dosage l-carnitine is an effective intervention for patients wit...
Source: Progress in Lipid Research - August 10, 2018 Category: Lipidology Source Type: research
Editorial Board
Publication date: July 2018Source: Progress in Lipid Research, Volume 71Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - August 3, 2018 Category: Lipidology Source Type: research
Innovations in improving lipid production: Algal chemical genetics
Publication date: Available online 12 July 2018Source: Progress in Lipid ResearchAuthor(s): Nishikant Wase, Paul Black, Concetta DiRussoAbstractPerturbation of a biological system with small molecules to achieve a desired phenotype or activity is commonly referred as chemical genetics. In pharmaceutical discovery, this approach is most often employed in target-based screening but in plants systems the focus is primarily on phenotypic selection for commercially relevant phenotype generation such as crop improvement or disease and pathogen resistance. Likewise, algae are considered feedstock organisms for viable and sustaina...
Source: Progress in Lipid Research - July 13, 2018 Category: Lipidology Source Type: research
