Learning during inflammation
Nature Immunology 18, 715 (2017).
doi:10.1038/ni.3782
Author: Zoltan Fehervari (Source: Nature Immunology)
Source: Nature Immunology - June 20, 2017 Category: Allergy & Immunology Authors: Zoltan Fehervari Tags: Research Highlights Source Type: research
A rheostat tuning thymic selection
Nature Immunology 18, 713 (2017).
doi:10.1038/ni.3778
Authors: Gerald P Morris & Stephen M Hedrick
Thymocytes must undergo positive selection to survive and differentiate. This process is regulated by the TCR-sensitive protein CHMPS by preventing Bcl2 oxidation and degradation. (Source: Nature Immunology)
Source: Nature Immunology - June 20, 2017 Category: Allergy & Immunology Authors: Gerald P Morris Stephen M Hedrick Tags: News and Views Source Type: research
Atypical matters in myeloid differentiation
Nature Immunology 18, 711 (2017).
doi:10.1038/ni.3776
Authors: Massimo Locati, Alberto Mantovani & Raffaella Bonecchi
Chemokines are important components of the hematopoietic niche. The atypical chemokine receptor 1 (ACKR1), expressed on erythrocyte precursors, regulates myeloid differentiation. (Source: Nature Immunology)
Source: Nature Immunology - June 20, 2017 Category: Allergy & Immunology Authors: Massimo Locati Alberto Mantovani Raffaella Bonecchi Tags: News and Views Source Type: research
A Hippo in the Fox(p3) house
Nature Immunology 18, 709 (2017).
doi:10.1038/ni.3769
Author: Mandy J McGeachy
The Hippo signaling pathway regulates cellular proliferation and survival during tissue growth and cancer. In CD4+ T cells, members of the Hippo family modulate autoimmune inflammation by altering interactions between the transcription factors Foxp3 and RORγt; this reveals an unexpected non-canonical role for Hippo in adaptive immunity. (Source: Nature Immunology)
Source: Nature Immunology - June 20, 2017 Category: Allergy & Immunology Authors: Mandy J McGeachy Tags: News and Views Source Type: research
Polymorphisms in IFIH1: the good and the bad
Nature Immunology 18, 708 (2017).
doi:10.1038/ni.3765
Authors: Erika Della Mina, Mathieu P Rodero & Yanick J Crow
A study of polymorphisms in the sensor IFIH1 exposes the evolutionary trade-off between a robust antiviral type I interferon response and the risk of interferon-mediated inflammation. (Source: Nature Immunology)
Source: Nature Immunology - June 20, 2017 Category: Allergy & Immunology Authors: Erika Della Mina Mathieu P Rodero Yanick J Crow Tags: News and Views Source Type: research
Julius Youngner 1920 – 2017
Nature Immunology 18, 707 (2017).
doi:10.1038/ni.3779
Author: Vincent Racaniello (Source: Nature Immunology)
Source: Nature Immunology - June 20, 2017 Category: Allergy & Immunology Authors: Vincent Racaniello Tags: Obituary Source Type: research
Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer
Nature Immunology 18, 940 (2017).
doi:10.1038/ni.3775
Authors: Anusha-Preethi Ganesan, James Clarke, Oliver Wood, Eva M Garrido-Martin, Serena J Chee, Toby Mellows, Daniela Samaniego-Castruita, Divya Singh, Grégory Seumois, Aiman Alzetani, Edwin Woo, Peter S Friedmann, Emma V King, Gareth J Thomas, Tilman Sanchez-Elsner, Pandurangan Vijayanand & Christian H Ottensmeier (Source: Nature Immunology)
Source: Nature Immunology - June 19, 2017 Category: Allergy & Immunology Authors: Anusha-Preethi Ganesan James Clarke Oliver Wood Eva M Garrido-Martin Serena J Chee Toby Mellows Daniela Samaniego-Castruita Divya Singh Gr é gory Seumois Aiman Alzetani Edwin Woo Peter S Friedmann Emma V King Gareth J Thomas Tilman Sanchez-Elsner Pandura Tags: Article Source Type: research
The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex
Nature Immunology 18, 911 (2017).
doi:10.1038/ni.3774
Authors: Elmar Dolezal, Simona Infantino, Friedel Drepper, Theresa Börsig, Aparajita Singh, Thomas Wossning, Gina J Fiala, Susana Minguet, Bettina Warscheid, David M Tarlinton, Hassan Jumaa, David Medgyesi & Michael Reth (Source: Nature Immunology)
Source: Nature Immunology - June 19, 2017 Category: Allergy & Immunology Authors: Elmar Dolezal Simona Infantino Friedel Drepper Theresa B ö rsig Aparajita Singh Thomas Wossning Gina J Fiala Susana Minguet Bettina Warscheid David M Tarlinton Hassan Jumaa David Medgyesi Michael Reth Tags: Article Source Type: research
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage
Nature Immunology 18, 931 (2017).
doi:10.1038/ni.3773
Authors: Qiang Shan, Zhouhao Zeng, Shaojun Xing, Fengyin Li, Stacey M Hartwig, Jodi A Gullicksrud, Samarchith P Kurup, Natalija Van Braeckel-Budimir, Yao Su, Matthew D Martin, Steven M Varga, Ichiro Taniuchi, John T Harty, Weiqun Peng, Vladimir P Badovinac & Hai-Hui Xue (Source: Nature Immunology)
Source: Nature Immunology - June 12, 2017 Category: Allergy & Immunology Authors: Qiang Shan Zhouhao Zeng Shaojun Xing Fengyin Li Stacey M Hartwig Jodi A Gullicksrud Samarchith P Kurup Natalija Van Braeckel-Budimir Yao Su Matthew D Martin Steven M Varga Ichiro Taniuchi John T Harty Weiqun Peng Vladimir P Badovinac Hai-Hui Xue Tags: Article Source Type: research
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense
Nature Immunology 18, 899 (2017).
doi:10.1038/ni.3767
Authors: Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Shuhei Nakamura, Tsuyoshi Kawabata, Hironori Bando, Youngae Lee, Tatsuya Saitoh, Shizuo Akira, Akiko Iwasaki, Daron M Standley, Tamotsu Yoshimori & Masahiro Yamamoto (Source: Nature Immunology)
Source: Nature Immunology - June 12, 2017 Category: Allergy & Immunology Authors: Miwa Sasai Naoya Sakaguchi Ji Su Ma Shuhei Nakamura Tsuyoshi Kawabata Hironori Bando Youngae Lee Tatsuya Saitoh Shizuo Akira Akiko Iwasaki Daron M Standley Tamotsu Yoshimori Masahiro Yamamoto Tags: Article Source Type: research
IgG Fc domains that bind C1q but not effector Fc γ receptors delineate the importance of complement-mediated effector functions
Nature Immunology 18, 889 (2017).
doi:10.1038/ni.3770
Authors: Chang-Han Lee, Gabrielle Romain, Wupeng Yan, Makiko Watanabe, Wissam Charab, Biliana Todorova, Jiwon Lee, Kendra Triplett, Moses Donkor, Oana I Lungu, Anja Lux, Nicholas Marshall, Margaret A Lindorfer, Odile Richard-Le Goff, Bianca Balbino, Tae Hyun Kang, Hidetaka Tanno, George Delidakis, Corrine Alford, Ronald P Taylor, Falk Nimmerjahn, Navin Varadarajan, Pierre Bruhns, Yan Jessie Zhang & George Georgiou (Source: Nature Immunology)
Source: Nature Immunology - June 12, 2017 Category: Allergy & Immunology Authors: Chang-Han Lee Gabrielle Romain Wupeng Yan Makiko Watanabe Wissam Charab Biliana Todorova Jiwon Lee Kendra Triplett Moses Donkor Oana I Lungu Anja Lux Nicholas Marshall Margaret A Lindorfer Odile Richard-Le Goff Bianca Balbino Tae Hyun Kang Hidetaka Tanno Tags: Article Source Type: research
Post-translational control of T cell development by the ESCRT protein CHMP5
Nature Immunology 18, 780 (2017).
doi:10.1038/ni.3764
Authors: Stanley Adoro, Kwang Hwan Park, Sarah E Bettigole, Raphael Lis, Hee Rae Shin, Heewon Seo, Ju Han Kim, Klaus-Peter Knobeloch, Jae-Hyuck Shim & Laurie H Glimcher (Source: Nature Immunology)
Source: Nature Immunology - May 29, 2017 Category: Allergy & Immunology Authors: Stanley Adoro Kwang Hwan Park Sarah E Bettigole Raphael Lis Hee Rae Shin Heewon Seo Ju Han Kim Klaus-Peter Knobeloch Jae-Hyuck Shim Laurie H Glimcher Tags: Article Source Type: research
Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis
Nature Immunology 18, 753 (2017).
doi:10.1038/ni.3763
Authors: Johan Duchene, Igor Novitzky-Basso, Aude Thiriot, Maria Casanova-Acebes, Mariaelvy Bianchini, S Leah Etheridge, Elin Hub, Katrin Nitz, Katharina Artinger, Kathrin Eller, Jorge Caamaño, Thomas Rülicke, Paul Moss, Remco T A Megens, Ulrich H von Andrian, Andres Hidalgo, Christian Weber & Antal Rot (Source: Nature Immunology)
Source: Nature Immunology - May 29, 2017 Category: Allergy & Immunology Authors: Johan Duchene Igor Novitzky-Basso Aude Thiriot Maria Casanova-Acebes Mariaelvy Bianchini S Leah Etheridge Elin Hub Katrin Nitz Katharina Artinger Kathrin Eller Jorge Caama ñ o Thomas R ü licke Paul Moss Remco T A Megens Ulrich H von Andrian Andres Hidal Tags: Article Source Type: research
The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity
Nature Immunology 18, 744 (2017).
doi:10.1038/ni.3766
Authors: Jacquelyn A Gorman, Christian Hundhausen, John S Errett, Amy E Stone, Eric J Allenspach, Yan Ge, Tanvi Arkatkar, Courtnee Clough, Xuezhi Dai, Socheath Khim, Kathleen Pestal, Denny Liggitt, Karen Cerosaletti, Daniel B Stetson, Richard G James, Mohamed Oukka, Patrick Concannon, Michael Gale, Jane H Buckner & David J Rawlings (Source: Nature Immunology)
Source: Nature Immunology - May 29, 2017 Category: Allergy & Immunology Authors: Jacquelyn A Gorman Christian Hundhausen John S Errett Amy E Stone Eric J Allenspach Yan Ge Tanvi Arkatkar Courtnee Clough Xuezhi Dai Socheath Khim Kathleen Pestal Denny Liggitt Karen Cerosaletti Daniel B Stetson Richard G James Mohamed Oukka Patrick Conca Tags: Article Source Type: research
BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency
Nature Immunology 18, 813 (2017).
doi:10.1038/ni.3753
Authors: Behdad Afzali, Juha Grönholm, Jana Vandrovcova, Charlotte O'Brien, Hong-Wei Sun, Ine Vanderleyden, Fred P Davis, Ahmad Khoder, Yu Zhang, Ahmed N Hegazy, Alejandro V Villarino, Ira W Palmer, Joshua Kaufman, Norman R Watts, Majid Kazemian, Olena Kamenyeva, Julia Keith, Anwar Sayed, Dalia Kasperaviciute, Michael Mueller, Jason D Hughes, Ivan J Fuss, Mohammed F Sadiyah, Kim Montgomery-Recht, Joshua McElwee, Nicholas P Restifo, Warren Strober, Michelle A Linterman, Paul T Wingfield, Holm H Uhlig, Rahul Roychoudhuri, Timothy J Aitman, Peter Kelleher, Mic...
Source: Nature Immunology - May 22, 2017 Category: Allergy & Immunology Authors: Behdad Afzali Juha Gr ö nholm Jana Vandrovcova Charlotte O'Brien Hong-Wei Sun Ine Vanderleyden Fred P Davis Ahmad Khoder Yu Zhang Ahmed N Hegazy Alejandro V Villarino Ira W Palmer Joshua Kaufman Norman R Watts Majid Kazemian Olena Kamenyeva Julia Keith A Tags: Article Source Type: research
