Alternative monocytes settle in for the long term
Nature Immunology 18, 599 (2017).
doi:10.1038/ni.3749
Authors: Allan McI Mowat & Calum C Bain
Monocytes recruited to the peritoneum under conditions of a type 2 inflammatory reaction can convert into resident-type macrophages under the control of vitamin A. (Source: Nature Immunology)
Source: Nature Immunology - May 18, 2017 Category: Allergy & Immunology Authors: Allan McI Mowat Calum C Bain Tags: News and Views Source Type: research
STAT5 alters the state of transcriptional networks, driving aggressive leukemia
Nature Immunology 18, 597 (2017).
doi:10.1038/ni.3747
Authors: Sinisa Dovat & Kimberly J Payne
The transcription factor STAT5 acts as an oncoprotein in B cell acute lymphoblastic leukemia, competing with the transcription factors NF-κB and Ikaros for binding to DNA. (Source: Nature Immunology)
Source: Nature Immunology - May 18, 2017 Category: Allergy & Immunology Authors: Sinisa Dovat Kimberly J Payne Tags: News and Views Source Type: research
RNA-binding proteins, the guardians of the marginal zone
Nature Immunology 18, 595 (2017).
doi:10.1038/ni.3752
Authors: Palaniraja Thandapani, Beatriz Aranda-Orgilles & Iannis Aifantis
RNA-binding proteins (RBPs) take control of binary cell-fate 'decisions' and cellular identity in lymphoid organs, as the RBP ZFP36L1 is shown to negatively regulate the stability of the transcription factors KLF2 and IRF8 to control the maintenance, survival and localization of marginal zone B cells. (Source: Nature Immunology)
Source: Nature Immunology - May 18, 2017 Category: Allergy & Immunology Authors: Palaniraja Thandapani Beatriz Aranda-Orgilles Iannis Aifantis Tags: News and Views Source Type: research
The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
Nature Immunology 18, 800 (2017).
doi:10.1038/ni.3748
Authors: Jing Geng, Shujuan Yu, Hao Zhao, Xiufeng Sun, Xun Li, Ping Wang, Xiaolin Xiong, Lixin Hong, Changchuan Xie, Jiahui Gao, Yiran Shi, Jiaqi Peng, Randy L Johnson, Nengming Xiao, Linrong Lu, Jiahuai Han, Dawang Zhou & Lanfen Chen (Source: Nature Immunology)
Source: Nature Immunology - May 15, 2017 Category: Allergy & Immunology Authors: Jing Geng Shujuan Yu Hao Zhao Xiufeng Sun Xun Li Ping Wang Xiaolin Xiong Lixin Hong Changchuan Xie Jiahui Gao Yiran Shi Jiaqi Peng Randy L Johnson Nengming Xiao Linrong Lu Jiahuai Han Dawang Zhou Lanfen Chen Tags: Article Source Type: research
Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1
Nature Immunology 18, 762 (2017).
doi:10.1038/ni.3750
Authors: Louise A Johnson, Suneale Banerji, William Lawrance, Uzi Gileadi, Gennaro Prota, Kayla A Holder, Yaowaluck M Roshorm, Tomáš Hanke, Vincenzo Cerundolo, Nicholas W Gale & David G Jackson (Source: Nature Immunology)
Source: Nature Immunology - May 15, 2017 Category: Allergy & Immunology Authors: Louise A Johnson Suneale Banerji William Lawrance Uzi Gileadi Gennaro Prota Kayla A Holder Yaowaluck M Roshorm Tom á š Hanke Vincenzo Cerundolo Nicholas W Gale David G Jackson Tags: Article Source Type: research
YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKK ɛ -mediated phosphorylation
Nature Immunology 18, 733 (2017).
doi:10.1038/ni.3744
Authors: Shuai Wang, Feng Xie, Feng Chu, Zhengkui Zhang, Bing Yang, Tong Dai, Liang Gao, Lin Wang, Li Ling, Junling Jia, Hans van Dam, Jin Jin, Long Zhang & Fangfang Zhou (Source: Nature Immunology)
Source: Nature Immunology - May 8, 2017 Category: Allergy & Immunology Authors: Shuai Wang Feng Xie Feng Chu Zhengkui Zhang Bing Yang Tong Dai Liang Gao Lin Wang Li Ling Junling Jia Hans van Dam Jin Jin Long Zhang Fangfang Zhou Tags: Article Source Type: research
Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure
Nature Immunology 18, 665 (2017).
doi:10.1038/ni.3746
Authors: Yochai Wolf, Sigalit Boura-Halfon, Nina Cortese, Zhana Haimon, Hadas Sar Shalom, Yael Kuperman, Vyacheslav Kalchenko, Alexander Brandis, Eyal David, Yifat Segal-Hayoun, Louise Chappell-Maor, Avraham Yaron & Steffen Jung (Source: Nature Immunology)
Source: Nature Immunology - May 1, 2017 Category: Allergy & Immunology Authors: Yochai Wolf Sigalit Boura-Halfon Nina Cortese Zhana Haimon Hadas Sar Shalom Yael Kuperman Vyacheslav Kalchenko Alexander Brandis Eyal David Yifat Segal-Hayoun Louise Chappell-Maor Avraham Yaron Steffen Jung Tags: Article Source Type: research
Mice deficient in NRROS show abnormal microglial development and neurological disorders
Nature Immunology 18, 633 (2017).
doi:10.1038/ni.3743
Authors: Kit Wong, Rajkumar Noubade, Paolo Manzanillo, Naruhisa Ota, Oded Foreman, Jason A Hackney, Brad A Friedman, Rajita Pappu, Kimberly Scearce-Levie & Wenjun Ouyang (Source: Nature Immunology)
Source: Nature Immunology - May 1, 2017 Category: Allergy & Immunology Authors: Kit Wong Rajkumar Noubade Paolo Manzanillo Naruhisa Ota Oded Foreman Jason A Hackney Brad A Friedman Rajita Pappu Kimberly Scearce-Levie Wenjun Ouyang Tags: Article Source Type: research
S100-alarmin-induced innate immune programming protects newborn infants from sepsis
Nature Immunology 18, 622 (2017).
doi:10.1038/ni.3745
Authors: Thomas Ulas, Sabine Pirr, Beate Fehlhaber, Marie S Bickes, Torsten G Loof, Thomas Vogl, Lara Mellinger, Anna S Heinemann, Johanna Burgmann, Jennifer Schöning, Sabine Schreek, Sandra Pfeifer, Friederike Reuner, Lena Völlger, Martin Stanulla, Maren von Köckritz-Blickwede, Shirin Glander, Katarzyna Barczyk-Kahlert, Constantin S von Kaisenberg, Judith Friesenhagen, Lena Fischer-Riepe, Stefanie Zenker, Joachim L Schultze, Johannes Roth & Dorothee Viemann (Source: Nature Immunology)
Source: Nature Immunology - May 1, 2017 Category: Allergy & Immunology Authors: Thomas Ulas Sabine Pirr Beate Fehlhaber Marie S Bickes Torsten G Loof Thomas Vogl Lara Mellinger Anna S Heinemann Johanna Burgmann Jennifer Sch ö ning Sabine Schreek Sandra Pfeifer Friederike Reuner Lena V ö llger Martin Stanulla Maren von K ö ckritz-B Tags: Article Source Type: research
Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota
Nature Immunology 18, 675 (2017).
doi:10.1038/ni.3732
Authors: Kazuki Nagashima, Shinichiro Sawa, Takeshi Nitta, Masanori Tsutsumi, Tadashi Okamura, Josef M Penninger, Tomoki Nakashima & Hiroshi Takayanagi (Source: Nature Immunology)
Source: Nature Immunology - April 24, 2017 Category: Allergy & Immunology Authors: Kazuki Nagashima Shinichiro Sawa Takeshi Nitta Masanori Tsutsumi Tadashi Okamura Josef M Penninger Tomoki Nakashima Hiroshi Takayanagi Tags: Article Source Type: research
Vitamin A mediates conversion of monocyte-derived macrophages into tissue-resident macrophages during alternative activation
Nature Immunology 18, 642 (2017).
doi:10.1038/ni.3734
Authors: Uma Mahesh Gundra, Natasha M Girgis, Michael A Gonzalez, Mei San Tang, Hendrik J P Van Der Zande, Jian-Da Lin, Mireille Ouimet, Lily J Ma, Jordan Poles, Nikollaq Vozhilla, Edward A Fisher, Kathryn J Moore & P'ng Loke (Source: Nature Immunology)
Source: Nature Immunology - April 24, 2017 Category: Allergy & Immunology Authors: Uma Mahesh Gundra Natasha M Girgis Michael A Gonzalez Mei San Tang Hendrik J P Van Der Zande Jian-Da Lin Mireille Ouimet Lily J Ma Jordan Poles Nikollaq Vozhilla Edward A Fisher Kathryn J Moore P'ng Loke Tags: Article Source Type: research
Mitochondria are the powerhouses of immunity
Nature Immunology 18, 488 (2017).
doi:10.1038/ni.3704
Authors: Evanna L Mills, Beth Kelly & Luke A J O'Neill (Source: Nature Immunology)
Source: Nature Immunology - April 18, 2017 Category: Allergy & Immunology Authors: Evanna L Mills Beth Kelly Luke A J O'Neill Tags: Review Source Type: research
Vitamin C for microglia
Nature Immunology 18, 487 (2017).
doi:10.1038/ni.3740
Author: Laurie A. Dempsey (Source: Nature Immunology)
Source: Nature Immunology - April 18, 2017 Category: Allergy & Immunology Authors: Laurie A. Dempsey Tags: Research Highlights Source Type: research
PD-1 targets CD28
Nature Immunology 18, 487 (2017).
doi:10.1038/ni.3739
Author: Laurie A. Dempsey (Source: Nature Immunology)
Source: Nature Immunology - April 18, 2017 Category: Allergy & Immunology Authors: Laurie A. Dempsey Tags: Research Highlights Source Type: research
Marking HIV
Nature Immunology 18, 487 (2017).
doi:10.1038/ni.3738
Author: Ioana Visan (Source: Nature Immunology)
Source: Nature Immunology - April 18, 2017 Category: Allergy & Immunology Authors: Ioana Visan Tags: Research Highlights Source Type: research
