MLL4 keeps Foxp3 in the loop
Nature Immunology 18, 957 (2017).
doi:10.1038/ni.3811
Authors: Dong-Mei Zhao & Hai-Hui Xue
The histone lysine methyltransferase MLL4 primes the locus encoding the transcription factor Foxp3 for transcriptional activation in thymus-derived and inducible regulatory T cells. (Source: Nature Immunology)
Source: Nature Immunology - August 22, 2017 Category: Allergy & Immunology Authors: Dong-Mei Zhao Hai-Hui Xue Tags: News and Views Source Type: research
Fat T cells go to the joint
Nature Immunology 18, 955 (2017).
doi:10.1038/ni.3810
Author: George C Tsokos
Poor glycolysis and increased fatty-acid synthesis feed the locomotion machinery in T cells from people with rheumatoid arthritis and allow these cells to enter the synovium and propagate joint inflammation and destruction. (Source: Nature Immunology)
Source: Nature Immunology - August 22, 2017 Category: Allergy & Immunology Authors: George C Tsokos Tags: News and Views Source Type: research
Myelopoiesis embraces its inner weakness
Nature Immunology 18, 953 (2017).
doi:10.1038/ni.3814
Authors: Motti Gerlic & Ben A Croker
The ability to expand and contract populations of myeloid and lymphoid cells during emergency hematopoiesis helps shape the immune response. The expression of intracellular and soluble forms of osteopontin regulates apoptosis thresholds differently in myeloid cells and lymphoid cells to counter infection. (Source: Nature Immunology)
Source: Nature Immunology - August 22, 2017 Category: Allergy & Immunology Authors: Motti Gerlic Ben A Croker Tags: News and Views Source Type: research
Asynchronous lineage priming determines commitment to T cell and B cell lineages in fetal liver
Nature Immunology 18, 1139 (2017).
doi:10.1038/ni.3820
Authors: Claire Berthault, Cyrille Ramond, Odile Burlen-Defranoux, Guillaume Soubigou, Sylvestre Chea, Rachel Golub, Pablo Pereira, Paulo Vieira & Ana Cumano (Source: Nature Immunology)
Source: Nature Immunology - August 21, 2017 Category: Allergy & Immunology Authors: Claire Berthault Cyrille Ramond Odile Burlen-Defranoux Guillaume Soubigou Sylvestre Chea Rachel Golub Pablo Pereira Paulo Vieira Ana Cumano Tags: Article Source Type: research
Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation
Nature Immunology 18, 1104 (2017).
doi:10.1038/ni.3818
Authors: Sung Ho Park, Kyuho Kang, Eugenia Giannopoulou, Yu Qiao, Keunsoo Kang, Geonho Kim, Kyung-Hyun Park-Min & Lionel B Ivashkiv (Source: Nature Immunology)
Source: Nature Immunology - August 21, 2017 Category: Allergy & Immunology Authors: Sung Ho Park Kyuho Kang Eugenia Giannopoulou Yu Qiao Keunsoo Kang Geonho Kim Kyung-Hyun Park-Min Lionel B Ivashkiv Tags: Article Source Type: research
Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance
Nature Immunology 18, 1150 (2017).
doi:10.1038/ni.3813
Authors: Susana Minguet, Kathrin Kläsener, Anna-Maria Schaffer, Gina J Fiala, Teresa Osteso-Ibánez, Katrin Raute, Inmaculada Navarro-Lérida, Frederike A Hartl, Maximilian Seidl, Michael Reth & Miguel A Del Pozo (Source: Nature Immunology)
Source: Nature Immunology - August 14, 2017 Category: Allergy & Immunology Authors: Susana Minguet Kathrin Kl ä sener Anna-Maria Schaffer Gina J Fiala Teresa Osteso-Ib á nez Katrin Raute Inmaculada Navarro-L é rida Frederike A Hartl Maximilian Seidl Michael Reth Miguel A Del Pozo Tags: Article Source Type: research
T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation
Nature Immunology 18, 1117 (2017).
doi:10.1038/ni.3816
Authors: Brandon Kwong, Rejane Rua, Yuanyuan Gao, John Flickinger, Yan Wang, Michael J Kruhlak, Jinfang Zhu, Eric Vivier, Dorian B McGavern & Vanja Lazarevic (Source: Nature Immunology)
Source: Nature Immunology - August 14, 2017 Category: Allergy & Immunology Authors: Brandon Kwong Rejane Rua Yuanyuan Gao John Flickinger Yan Wang Michael J Kruhlak Jinfang Zhu Eric Vivier Dorian B McGavern Vanja Lazarevic Tags: Article Source Type: research
Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues
Nature Immunology 18, 1160 (2017).
doi:10.1038/ni.3799
Authors: Michael Delacher, Charles D Imbusch, Dieter Weichenhan, Achim Breiling, Agnes Hotz-Wagenblatt, Ulrike Träger, Ann-Cathrin Hofer, Danny Kägebein, Qi Wang, Felix Frauhammer, Jan-Philipp Mallm, Katharina Bauer, Carl Herrmann, Philipp A Lang, Benedikt Brors, Christoph Plass & Markus Feuerer (Source: Nature Immunology)
Source: Nature Immunology - August 7, 2017 Category: Allergy & Immunology Authors: Michael Delacher Charles D Imbusch Dieter Weichenhan Achim Breiling Agnes Hotz-Wagenblatt Ulrike Tr ä ger Ann-Cathrin Hofer Danny K ä gebein Qi Wang Felix Frauhammer Jan-Philipp Mallm Katharina Bauer Carl Herrmann Philipp A Lang Benedikt Brors Christoph Tags: Research Source Type: research
MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping
Nature Immunology 18, 1035 (2017).
doi:10.1038/ni.3812
Authors: Katarzyna Placek, Gangqing Hu, Kairong Cui, Dunfang Zhang, Yi Ding, Ji-Eun Lee, Younghoon Jang, Chaochen Wang, Joanne Elizabeth Konkel, Jiuzhou Song, Chengyu Liu, Kai Ge, Wanjun Chen & Keji Zhao (Source: Nature Immunology)
Source: Nature Immunology - July 31, 2017 Category: Allergy & Immunology Authors: Katarzyna Placek Gangqing Hu Kairong Cui Dunfang Zhang Yi Ding Ji-Eun Lee Younghoon Jang Chaochen Wang Joanne Elizabeth Konkel Jiuzhou Song Chengyu Liu Kai Ge Wanjun Chen Keji Zhao Tags: Article Source Type: research
Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells
Nature Immunology 18, 1004 (2017).
doi:10.1038/ni.3800
Authors: Yulong Gao, Fernando Souza-Fonseca-Guimaraes, Tobias Bald, Susanna S Ng, Arabella Young, Shin Foong Ngiow, Jai Rautela, Jasmin Straube, Nic Waddell, Stephen J Blake, Juming Yan, Laurent Bartholin, Jason S Lee, Eric Vivier, Kazuyoshi Takeda, Meriem Messaoudene, Laurence Zitvogel, Michele W L Teng, Gabrielle T Belz, Christian R Engwerda, Nicholas D Huntington, Kyohei Nakamura, Michael Hölzel & Mark J Smyth (Source: Nature Immunology)
Source: Nature Immunology - July 31, 2017 Category: Allergy & Immunology Authors: Yulong Gao Fernando Souza-Fonseca-Guimaraes Tobias Bald Susanna S Ng Arabella Young Shin Foong Ngiow Jai Rautela Jasmin Straube Nic Waddell Stephen J Blake Juming Yan Laurent Bartholin Jason S Lee Eric Vivier Kazuyoshi Takeda Meriem Messaoudene Laurence Z Tags: Article Source Type: research
SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF- β signaling
Nature Immunology 18, 995 (2017).
doi:10.1038/ni.3809
Authors: Victor S Cortez, Tyler K Ulland, Luisa Cervantes-Barragan, Jennifer K Bando, Michelle L Robinette, Qianli Wang, Andrew J White, Susan Gilfillan, Marina Cella & Marco Colonna (Source: Nature Immunology)
Source: Nature Immunology - July 31, 2017 Category: Allergy & Immunology Authors: Victor S Cortez Tyler K Ulland Luisa Cervantes-Barragan Jennifer K Bando Michelle L Robinette Qianli Wang Andrew J White Susan Gilfillan Marina Cella Marco Colonna Tags: Article Source Type: research
Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells
Nature Immunology 18, 1025 (2017).
doi:10.1038/ni.3808
Authors: Yi Shen, Zhenke Wen, Yinyin Li, Eric L Matteson, Jison Hong, Jörg J Goronzy & Cornelia M Weyand (Source: Nature Immunology)
Source: Nature Immunology - July 24, 2017 Category: Allergy & Immunology Authors: Yi Shen Zhenke Wen Yinyin Li Eric L Matteson Jison Hong J ö rg J Goronzy Cornelia M Weyand Tags: Article Source Type: research
Erratum: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth
Nature Immunology 18, 951 (2017).
doi:10.1038/ni0817-951e
Author: Liang Chen, Justin E Wilson, Mark J Koenigsknecht, Wei-Chun Chou, Stephanie A Montgomery, Agnieszka D Truax, W June Brickey, Christopher D Packey, Nitsan Maharshak, Glenn K Matsushima, Scott E Plevy, Vincent B Young, R Balfour Sartor & Jenny P-Y Ting (Source: Nature Immunology)
Source: Nature Immunology - July 19, 2017 Category: Allergy & Immunology Authors: Liang Chen Justin E Wilson Mark J Koenigsknecht Wei-Chun Chou Stephanie A Montgomery Agnieszka D Truax W June Brickey Christopher D Packey Nitsan Maharshak Glenn K Matsushima Scott E Plevy Vincent B Young R Balfour Sartor Jenny P-Y Ting Tags: Erratum Source Type: research
Erratum: Ontogeny and homeostasis of CNS myeloid cells
Nature Immunology 18, 951 (2017).
doi:10.1038/ni0817-951d
Author: Marco Prinz, Daniel Erny & Nora Hagemeyer (Source: Nature Immunology)
Source: Nature Immunology - July 19, 2017 Category: Allergy & Immunology Authors: Marco Prinz Daniel Erny Nora Hagemeyer Tags: Erratum Source Type: research
Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
Nature Immunology 18, 951 (2017).
doi:10.1038/ni0817-951c
Author: Eliana Mariño, James L Richards, Keiran H McLeod, Dragana Stanley, Yu Anne Yap, Jacinta Knight, Craig McKenzie, Jan Kranich, Ana Carolina Oliveira, Fernando J Rossello, Balasubramanian Krishnamurthy, Christian M Nefzger, Laurence Macia, Alison Thorburn, Alan G Baxter, Grant Morahan, Lee H Wong, Jose M Polo, Robert J Moore, Trevor J Lockett, Julie M Clarke, David L Topping, Leonard C Harrison & Charles R Mackay (Source: Nature Immunology)
Source: Nature Immunology - July 19, 2017 Category: Allergy & Immunology Authors: Eliana Mari ñ o James L Richards Keiran H McLeod Dragana Stanley Yu Anne Yap Jacinta Knight Craig McKenzie Jan Kranich Ana Carolina Oliveira Fernando J Rossello Balasubramanian Krishnamurthy Christian M Nefzger Laurence Macia Alison Thorburn Alan G Baxte Tags: Erratum Source Type: research
