Tim-3 promotes maternal tolerance
Nature Immunology 18, 1189 (2017).
doi:10.1038/ni.3861
Author: Laurie A. Dempsey (Source: Nature Immunology)
Source: Nature Immunology - October 18, 2017 Category: Allergy & Immunology Authors: Laurie A. Dempsey Tags: Research Highlights Source Type: research
CD28 enhances mitochondrial function
Nature Immunology 18, 1189 (2017).
doi:10.1038/ni.3860
Author: Laurie A. Dempsey (Source: Nature Immunology)
Source: Nature Immunology - October 18, 2017 Category: Allergy & Immunology Authors: Laurie A. Dempsey Tags: Research Highlights Source Type: research
Killer T cells with a beta-flavi(r) for dengue
Nature Immunology 18, 1186 (2017).
doi:10.1038/ni.3833
Authors: Sydney Blevins & Eric S Huseby
Dysfunctional immunity is associated with dengue hemorrhagic fever and dengue shock syndrome. Structural analyses reveal that a key germline-encoded contact between the T cell antigen receptor and a peptide underpins the immunodominance of dengue-virus-specific CD8+ T cell responses of weak affinity. (Source: Nature Immunology)
Source: Nature Immunology - October 18, 2017 Category: Allergy & Immunology Authors: Sydney Blevins Eric S Huseby Tags: News and Views Source Type: research
TFR cells trump autoimmune antibody responses to limit sedition
Nature Immunology 18, 1185 (2017).
doi:10.1038/ni.3856
Authors: Michelle A Linterman & Kai-Michael Toellner
The differentiation of follicular regulatory T cells can be limited by the cytokine IL-2, preventing the emergence of autoantibodies. This research identifies these cells as key regulators of the germinal center response. (Source: Nature Immunology)
Source: Nature Immunology - October 18, 2017 Category: Allergy & Immunology Authors: Michelle A Linterman Kai-Michael Toellner Tags: News and Views Source Type: research
Cytokine-driven role of Srebps in killer cell metabolism
Nature Immunology 18, 1183 (2017).
doi:10.1038/ni.3855
Authors: Camille Guillerey & Mark J Smyth
A new and unexpected role is identified for Srebps in controlling NK cell activity that is independent of their role in lipid biosynthesis. (Source: Nature Immunology)
Source: Nature Immunology - October 18, 2017 Category: Allergy & Immunology Authors: Camille Guillerey Mark J Smyth Tags: News and Views Source Type: research
FoxP3 partners up
Nature Immunology 18, 1181 (2017).
doi:10.1038/ni.3852
Authors: David Bending & Masahiro Ono
By switching its partners, FoxP3 segregates into functional and non-functional transcriptional complexes. (Source: Nature Immunology)
Source: Nature Immunology - October 18, 2017 Category: Allergy & Immunology Authors: David Bending Masahiro Ono Tags: News and Views Source Type: research
Biomarkers of chronic inflammation in disease development and prevention: challenges and opportunities
Nature Immunology 18, 1175 (2017).
doi:10.1038/ni.3828
Authors: Christina H Liu, Natalie D Abrams, Danielle M Carrick, Preethi Chander, Johanna Dwyer, Michelle R J Hamlet, Francesca Macchiarini, Mercy PrabhuDas, Grace L Shen, Pushpa Tandon & Merriline M Vedamony
The US National Institutes of Health convened a workshop on disease-promoting chronic inflammation to identify the challenges and needs in the development of clinically feasible strategies for monitoring a person's inflammation status before, during and after disease occurrence. (Source: Nature Immunology)
Source: Nature Immunology - October 18, 2017 Category: Allergy & Immunology Authors: Christina H Liu Natalie D Abrams Danielle M Carrick Preethi Chander Johanna Dwyer Michelle R J Hamlet Francesca Macchiarini Mercy PrabhuDas Grace L Shen Pushpa Tandon Merriline M Vedamony Tags: Meeting Report Source Type: research
A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes
Nature Immunology 18, 1310 (2017).
doi:10.1038/ni.3857
Authors: Bénédicte Machiels, Mickael Dourcy, Xue Xiao, Justine Javaux, Claire Mesnil, Catherine Sabatel, Daniel Desmecht, François Lallemand, Philippe Martinive, Hamida Hammad, Martin Guilliams, Benjamin Dewals, Alain Vanderplasschen, Bart N Lambrecht, Fabrice Bureau & Laurent Gillet (Source: Nature Immunology)
Source: Nature Immunology - October 16, 2017 Category: Allergy & Immunology Authors: B é n é dicte Machiels Mickael Dourcy Xue Xiao Justine Javaux Claire Mesnil Catherine Sabatel Daniel Desmecht Fran ç ois Lallemand Philippe Martinive Hamida Hammad Martin Guilliams Benjamin Dewals Alain Vanderplasschen Bart N Lambrecht Fabrice Bureau L Tags: Article Source Type: research
Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes
Nature Immunology 18, 1321 (2017).
doi:10.1038/ni.3854
Authors: Ophélie Rouxel, Jennifer Da silva, Lucie Beaudoin, Isabelle Nel, Céline Tard, Lucie Cagninacci, Badr Kiaf, Masaya Oshima, Marc Diedisheim, Marion Salou, Alexandra Corbett, Jamie Rossjohn, James McCluskey, Raphael Scharfmann, Manuela Battaglia, Michel Polak, Olivier Lantz, Jacques Beltrand & Agnès Lehuen (Source: Nature Immunology)
Source: Nature Immunology - October 9, 2017 Category: Allergy & Immunology Authors: Oph é lie Rouxel Jennifer Da silva Lucie Beaudoin Isabelle Nel C é line Tard Lucie Cagninacci Badr Kiaf Masaya Oshima Marc Diedisheim Marion Salou Alexandra Corbett Jamie Rossjohn James McCluskey Raphael Scharfmann Manuela Battaglia Michel Polak Olivier Tags: Article Source Type: research
NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR
Nature Immunology 18, 1299 (2017).
doi:10.1038/ni.3853
Authors: Hui Feng, Erik M Lenarcic, Daisuke Yamane, Eliane Wauthier, Jinyao Mo, Haitao Guo, David R McGivern, Olga González-López, Ichiro Misumi, Lola M Reid, Jason K Whitmire, Jenny P-Y Ting, Joseph A Duncan, Nathaniel J Moorman & Stanley M Lemon (Source: Nature Immunology)
Source: Nature Immunology - October 2, 2017 Category: Allergy & Immunology Authors: Hui Feng Erik M Lenarcic Daisuke Yamane Eliane Wauthier Jinyao Mo Haitao Guo David R McGivern Olga Gonz á lez-L ó pez Ichiro Misumi Lola M Reid Jason K Whitmire Jenny P-Y Ting Joseph A Duncan Nathaniel J Moorman Stanley M Lemon Tags: Article Source Type: research
Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection
Nature Immunology 18, 1261 (2017).
doi:10.1038/ni.3849
Authors: Estefania Fernandez, Wanwisa Dejnirattisai, Bin Cao, Suzanne M Scheaffer, Piyada Supasa, Wiyada Wongwiwat, Prabagaran Esakky, Andrea Drury, Juthathip Mongkolsapaya, Kelle H Moley, Indira U Mysorekar, Gavin R Screaton & Michael S Diamond (Source: Nature Immunology)
Source: Nature Immunology - September 25, 2017 Category: Allergy & Immunology Authors: Estefania Fernandez Wanwisa Dejnirattisai Bin Cao Suzanne M Scheaffer Piyada Supasa Wiyada Wongwiwat Prabagaran Esakky Andrea Drury Juthathip Mongkolsapaya Kelle H Moley Indira U Mysorekar Gavin R Screaton Michael S Diamond Tags: Article Source Type: research
Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response
Nature Immunology 18, 1228 (2017).
doi:10.1038/ni.3850
Authors: Abigail Culshaw, Kristin Ladell, Stephanie Gras, James E McLaren, Kelly L Miners, Carine Farenc, Heleen van den Heuvel, Emma Gostick, Wanwisa Dejnirattisai, Apirath Wangteeraprasert, Thaneeya Duangchinda, Pojchong Chotiyarnwong, Wannee Limpitikul, Sirijitt Vasanawathana, Prida Malasit, Tao Dong, Jamie Rossjohn, Juthathip Mongkolsapaya, David A Price & Gavin R Screaton (Source: Nature Immunology)
Source: Nature Immunology - September 25, 2017 Category: Allergy & Immunology Authors: Abigail Culshaw Kristin Ladell Stephanie Gras James E McLaren Kelly L Miners Carine Farenc Heleen van den Heuvel Emma Gostick Wanwisa Dejnirattisai Apirath Wangteeraprasert Thaneeya Duangchinda Pojchong Chotiyarnwong Wannee Limpitikul Sirijitt Vasanawatha Tags: Article Source Type: research
Identification of lineage-specifying cytokines that signal all CD8+-cytotoxic-lineage-fate 'decisions' in the thymus
Nature Immunology 18, 1218 (2017).
doi:10.1038/ni.3847
Authors: Ruth Etzensperger, Tejas Kadakia, Xuguang Tai, Amala Alag, Terry I Guinter, Takeshi Egawa, Batu Erman & Alfred Singer (Source: Nature Immunology)
Source: Nature Immunology - September 25, 2017 Category: Allergy & Immunology Authors: Ruth Etzensperger Tejas Kadakia Xuguang Tai Amala Alag Terry I Guinter Takeshi Egawa Batu Erman Alfred Singer Tags: Article Source Type: research
Erratum: Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors
Nature Immunology 18, 1173 (2017).
doi:10.1038/ni1017-1173e
Author: Jaeyop Lee, Yu Jerry Zhou, Wenji Ma, Wanwei Zhang, Arafat Aljoufi, Thomas Luh, Kimberly Lucero, Deguang Liang, Matthew Thomsen, Govind Bhagat, Yufeng Shen & Kang Liu (Source: Nature Immunology)
Source: Nature Immunology - September 19, 2017 Category: Allergy & Immunology Authors: Jaeyop Lee Yu Jerry Zhou Wenji Ma Wanwei Zhang Arafat Aljoufi Thomas Luh Kimberly Lucero Deguang Liang Matthew Thomsen Govind Bhagat Yufeng Shen Kang Liu Tags: Erratum Source Type: research
Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection
Nature Immunology 18, 1173 (2017).
doi:10.1038/ni1017-1173d
Author: Howell F Moffett, Adam N R Cartwright, Hye-Jung Kim, Jernej Godec, Jason Pyrdol, Tarmo Äijö, Gustavo J Martinez, Anjana Rao, Jun Lu, Todd R Golub, Harvey Cantor, Arlene H Sharpe, Carl D Novina & Kai W Wucherpfennig (Source: Nature Immunology)
Source: Nature Immunology - September 19, 2017 Category: Allergy & Immunology Authors: Howell F Moffett Adam N R Cartwright Hye-Jung Kim Jernej Godec Jason Pyrdol Tarmo Ä ij ö Gustavo J Martinez Anjana Rao Jun Lu Todd R Golub Harvey Cantor Arlene H Sharpe Carl D Novina Kai W Wucherpfennig Tags: Erratum Source Type: research
