Killer T cells with a beta-flavi(r) for dengue

Nature Immunology 18, 1186 (2017). doi:10.1038/ni.3833 Authors: Sydney Blevins & Eric S Huseby Dysfunctional immunity is associated with dengue hemorrhagic fever and dengue shock syndrome. Structural analyses reveal that a key germline-encoded contact between the T cell antigen receptor and a peptide underpins the immunodominance of dengue-virus-specific CD8+ T cell responses of weak affinity.
Source: Nature Immunology - Category: Allergy & Immunology Authors: Tags: News and Views Source Type: research