Killer T cells with a beta-flavi(r) for dengue
Nature Immunology 18, 1186 (2017).
doi:10.1038/ni.3833
Authors: Sydney Blevins & Eric S Huseby
Dysfunctional immunity is associated with dengue hemorrhagic fever and dengue shock syndrome. Structural analyses reveal that a key germline-encoded contact between the T cell antigen receptor and a peptide underpins the immunodominance of dengue-virus-specific CD8+ T cell responses of weak affinity.
Source: Nature Immunology - Category: Allergy & Immunology Authors: Sydney Blevins Eric S Huseby Tags: News and Views Source Type: research
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