Dietary short-chain fatty acids protect against type 1 diabetes
Nature Immunology 18, 484 (2017).
doi:10.1038/ni.3730
Authors: Li Wen & F Susan Wong
The short-chain fatty acids (SCFAs) acetate and butyrate, which are released from specialized diets by gut microbes, protect non-obese diabetic (NOD) mice against insulitis and slow the progression of diabetes. (Source: Nature Immunology)
Source: Nature Immunology - April 18, 2017 Category: Allergy & Immunology Authors: Li Wen F Susan Wong Tags: News and Views Source Type: research
Gene-enhancer variants reveal diverse TCR-mediated differentiation
Nature Immunology 18, 483 (2017).
doi:10.1038/ni.3729
Authors: Michael P Gallagher & Leslie J Berg
The transcription factor IRF4 acts as a 'rheostat' for TCR signaling. Discrete levels of IRF4 can activate distinct transcriptional programs in T cells due to binding sites of variable affinity in groups of target genes. (Source: Nature Immunology)
Source: Nature Immunology - April 18, 2017 Category: Allergy & Immunology Authors: Michael P Gallagher Leslie J Berg Tags: News and Views Source Type: research
The immune system as a social network
Nature Immunology 18, 481 (2017).
doi:10.1038/ni.3727
Authors: Andreas Bergthaler & Jörg Menche
The immune system employs a multitude of molecules, cells and organs that act together throughout the entire body to guard human health. Much like in a social network, immune cells can exert full functionality only through effective collaboration and communication. (Source: Nature Immunology)
Source: Nature Immunology - April 18, 2017 Category: Allergy & Immunology Authors: Andreas Bergthaler J örg Menche Tags: News and Views Source Type: research
IRE1 gives weight to obesity-associated inflammation
Nature Immunology 18, 479 (2017).
doi:10.1038/ni.3725
Authors: Bojan Bujisic & Fabio Martinon
IRE1α is a stress sensor that is activated by a high-fat diet. In adipose-tissue macrophages, it serves as a major switch toward pro-inflammatory M1 polarization and thereby contributes to obesity and associated diseases. (Source: Nature Immunology)
Source: Nature Immunology - April 18, 2017 Category: Allergy & Immunology Authors: Bojan Bujisic Fabio Martinon Tags: News and Views Source Type: research
Speaking out about gender imbalance in invited speakers improves diversity
Nature Immunology 18, 475 (2017).
doi:10.1038/ni.3707
Authors: Robyn S Klein, Rhonda Voskuhl, Benjamin M Segal, Bonnie N Dittel, Thomas E Lane, John R Bethea, Monica J Carson, Carol Colton, Susanna Rosi, Aileen Anderson, Laura Piccio, Joan M Goverman, Etty N Benveniste, Melissa A Brown, Seema Kaushalya Tiwari-Woodruff, Tajie H Harris & Anne H Cross
Omissions of qualified women scientists from major meeting programs continue to occur despite a surge in articles indicating persistent gender-discriminatory practices in hiring and promotion, and calls for gender balance in conference organizing committees. (Source: Nature Immunology)
Source: Nature Immunology - April 18, 2017 Category: Allergy & Immunology Authors: Robyn S Klein Rhonda Voskuhl Benjamin M Segal Bonnie N Dittel Thomas E Lane John R Bethea Monica J Carson Carol Colton Susanna Rosi Aileen Anderson Laura Piccio Joan M Goverman Etty N Benveniste Melissa A Brown Seema Kaushalya Tiwari-Woodruff Tajie H Harr Tags: Comment Source Type: research
A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity
Nature Immunology 18, 654 (2017).
doi:10.1038/ni.3728
Authors: Kyoung-Jin Chung, Antonios Chatzigeorgiou, Matina Economopoulou, Ruben Garcia-Martin, Vasileia I Alexaki, Ioannis Mitroulis, Marina Nati, Janine Gebler, Tjalf Ziemssen, Susan E Goelz, Julia Phieler, Jong-Hyung Lim, Katia P Karalis, Thalia Papayannopoulou, Matthias Blüher, George Hajishengallis & Triantafyllos Chavakis (Source: Nature Immunology)
Source: Nature Immunology - April 17, 2017 Category: Allergy & Immunology Authors: Kyoung-Jin Chung Antonios Chatzigeorgiou Matina Economopoulou Ruben Garcia-Martin Vasileia I Alexaki Ioannis Mitroulis Marina Nati Janine Gebler Tjalf Ziemssen Susan E Goelz Julia Phieler Jong-Hyung Lim Katia P Karalis Thalia Papayannopoulou Matthias Bl à Tags: Article Source Type: research
Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1
Nature Immunology 18, 683 (2017).
doi:10.1038/ni.3724
Authors: Rebecca Newman, Helena Ahlfors, Alexander Saveliev, Alison Galloway, Daniel J Hodson, Robert Williams, Gurdyal S Besra, Charlotte N Cook, Adam F Cunningham, Sarah E Bell & Martin Turner (Source: Nature Immunology)
Source: Nature Immunology - April 10, 2017 Category: Allergy & Immunology Authors: Rebecca Newman Helena Ahlfors Alexander Saveliev Alison Galloway Daniel J Hodson Robert Williams Gurdyal S Besra Charlotte N Cook Adam F Cunningham Sarah E Bell Martin Turner Tags: Article Source Type: research
Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival
Nature Immunology 18, 694 (2017).
doi:10.1038/ni.3716
Authors: Casey D S Katerndahl, Lynn M Heltemes-Harris, Mark J L Willette, Christine M Henzler, Seth Frietze, Rendong Yang, Hilde Schjerven, Kevin A T Silverstein, Laura B Ramsey, Gregory Hubbard, Andrew D Wells, Roland P Kuiper, Blanca Scheijen, Frank N van Leeuwen, Markus Müschen, Steven M Kornblau & Michael A Farrar (Source: Nature Immunology)
Source: Nature Immunology - April 3, 2017 Category: Allergy & Immunology Authors: Casey D S Katerndahl Lynn M Heltemes-Harris Mark J L Willette Christine M Henzler Seth Frietze Rendong Yang Hilde Schjerven Kevin A T Silverstein Laura B Ramsey Gregory Hubbard Andrew D Wells Roland P Kuiper Blanca Scheijen Frank N van Leeuwen Markus M ü Tags: Article Source Type: research
Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF – IRF4 transcription factor complex
Nature Immunology 18, 563 (2017).
doi:10.1038/ni.3714
Authors: Arifumi Iwata, Vivek Durai, Roxane Tussiwand, Carlos G Briseño, Xiaodi Wu, Gary E Grajales-Reyes, Takeshi Egawa, Theresa L Murphy & Kenneth M Murphy (Source: Nature Immunology)
Source: Nature Immunology - March 27, 2017 Category: Allergy & Immunology Authors: Arifumi Iwata Vivek Durai Roxane Tussiwand Carlos G Brise ñ o Xiaodi Wu Gary E Grajales-Reyes Takeshi Egawa Theresa L Murphy Kenneth M Murphy Tags: Article Source Type: research
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
Nature Immunology 18, 552 (2017).
doi:10.1038/ni.3713
Authors: Eliana Mariño, James L Richards, Keiran H McLeod, Dragana Stanley, Yu Anne Yap, Jacinta Knight, Craig McKenzie, Jan Kranich, Ana Carolina Oliveira, Fernando J Rossello, Balasubramanian Krishnamurthy, Christian M Nefzger, Laurence Macia, Alison Thorburn, Alan G Baxter, Grant Morahan, Lee H Wong, Jose M Polo, Robert J Moore, Trevor J Lockett, Julie M Clarke, David L Topping, Leonard C Harrison & Charles R Mackay (Source: Nature Immunology)
Source: Nature Immunology - March 27, 2017 Category: Allergy & Immunology Authors: Eliana Mari ñ o James L Richards Keiran H McLeod Dragana Stanley Yu Anne Yap Jacinta Knight Craig McKenzie Jan Kranich Ana Carolina Oliveira Fernando J Rossello Balasubramanian Krishnamurthy Christian M Nefzger Laurence Macia Alison Thorburn Alan G Baxte Tags: Article Source Type: research
The metabolic ER stress sensor IRE1 α suppresses alternative activation of macrophages and impairs energy expenditure in obesity
Nature Immunology 18, 519 (2017).
doi:10.1038/ni.3709
Authors: Bo Shan, Xiaoxia Wang, Ying Wu, Chi Xu, Zhixiong Xia, Jianli Dai, Mengle Shao, Feng Zhao, Shengqi He, Liu Yang, Mingliang Zhang, Fajun Nan, Jia Li, Jianmiao Liu, Jianfeng Liu, Weiping Jia, Yifu Qiu, Baoliang Song, Jing-Dong J Han, Liangyou Rui, Sheng-Zhong Duan & Yong Liu (Source: Nature Immunology)
Source: Nature Immunology - March 27, 2017 Category: Allergy & Immunology Authors: Bo Shan Xiaoxia Wang Ying Wu Chi Xu Zhixiong Xia Jianli Dai Mengle Shao Feng Zhao Shengqi He Liu Yang Mingliang Zhang Fajun Nan Jia Li Jianmiao Liu Jianfeng Liu Weiping Jia Yifu Qiu Baoliang Song Jing-Dong J Han Liangyou Rui Sheng-Zhong Duan Yong Liu Tags: Article Source Type: research
Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF –IRF4 transcription factor complex
Nature Immunology 18, 563 (2017).
doi:10.1038/ni.3714
Authors: Arifumi Iwata, Vivek Durai, Roxane Tussiwand, Carlos G Briseño, Xiaodi Wu, Gary E Grajales-Reyes, Takeshi Egawa, Theresa L Murphy & Kenneth M Murphy (Source: Nature Immunology)
Source: Nature Immunology - March 27, 2017 Category: Allergy & Immunology Authors: Arifumi Iwata Vivek Durai Roxane Tussiwand Carlos G Brise ño Xiaodi Wu Gary E Grajales-Reyes Takeshi Egawa Theresa L Murphy Kenneth M Murphy Tags: Article Source Type: research
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
Nature Immunology 18, 552 (2017).
doi:10.1038/ni.3713
Authors: Eliana Mariño, James L Richards, Keiran H McLeod, Dragana Stanley, Yu Anne Yap, Jacinta Knight, Craig McKenzie, Jan Kranich, Ana Carolina Oliveira, Fernando J Rossello, Balasubramanian Krishnamurthy, Christian M Nefzger, Laurence Macia, Alison Thorburn, Alan G Baxter, Grant Morahan, Lee H Wong, Jose M Polo, Robert J Moore, Trevor J Lockett, Julie M Clarke, David L Topping, Leonard C Harrison & Charles R Mackay (Source: Nature Immunology)
Source: Nature Immunology - March 27, 2017 Category: Allergy & Immunology Authors: Eliana Mari ño James L Richards Keiran H McLeod Dragana Stanley Yu Anne Yap Jacinta Knight Craig McKenzie Jan Kranich Ana Carolina Oliveira Fernando J Rossello Balasubramanian Krishnamurthy Christian M Nefzger Laurence Macia Alison Thorburn Alan G Baxter Tags: Article Source Type: research
The metabolic ER stress sensor IRE1 α suppresses alternative activation of macrophages and impairs energy expenditure in obesity
Nature Immunology 18, 519 (2017).
doi:10.1038/ni.3709
Authors: Bo Shan, Xiaoxia Wang, Ying Wu, Chi Xu, Zhixiong Xia, Jianli Dai, Mengle Shao, Feng Zhao, Shengqi He, Liu Yang, Mingliang Zhang, Fajun Nan, Jia Li, Jianmiao Liu, Jianfeng Liu, Weiping Jia, Yifu Qiu, Baoliang Song, Jing-Dong J Han, Liangyou Rui, Sheng-Zhong Duan & Yong Liu (Source: Nature Immunology)
Source: Nature Immunology - March 27, 2017 Category: Allergy & Immunology Authors: Bo Shan Xiaoxia Wang Ying Wu Chi Xu Zhixiong Xia Jianli Dai Mengle Shao Feng Zhao Shengqi He Liu Yang Mingliang Zhang Fajun Nan Jia Li Jianmiao Liu Jianfeng Liu Weiping Jia Yifu Qiu Baoliang Song Jing-Dong J Han Liangyou Rui Sheng-Zhong Duan Yong Liu Tags: Article Source Type: research
Erratum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment
Nature Immunology 18, 474 (2017).
doi:10.1038/ni0417-474d
Author: Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota, Ryoji Kawakami, Keiko Yasuda, Daisuke Motooka, Shota Nakamura, Motonari Kondo, Ichiro Taniuchi, Terumi Kohwi-Shigematsu & Shimon Sakaguchi (Source: Nature Immunology)
Source: Nature Immunology - March 21, 2017 Category: Allergy & Immunology Authors: Yohko Kitagawa Naganari Ohkura Yujiro Kidani Alexis Vandenbon Keiji Hirota Ryoji Kawakami Keiko Yasuda Daisuke Motooka Shota Nakamura Motonari Kondo Ichiro Taniuchi Terumi Kohwi-Shigematsu Shimon Sakaguchi Tags: Erratum Source Type: research
