IRE1 gives weight to obesity-associated inflammation

Nature Immunology 18, 479 (2017). doi:10.1038/ni.3725 Authors: Bojan Bujisic & Fabio Martinon IRE1α is a stress sensor that is activated by a high-fat diet. In adipose-tissue macrophages, it serves as a major switch toward pro-inflammatory M1 polarization and thereby contributes to obesity and associated diseases.
Source: Nature Immunology - Category: Allergy & Immunology Authors: Tags: News and Views Source Type: research