A Hippo in the Fox(p3) house
Nature Immunology 18, 709 (2017).
doi:10.1038/ni.3769
Author: Mandy J McGeachy
The Hippo signaling pathway regulates cellular proliferation and survival during tissue growth and cancer. In CD4+ T cells, members of the Hippo family modulate autoimmune inflammation by altering interactions between the transcription factors Foxp3 and RORγt; this reveals an unexpected non-canonical role for Hippo in adaptive immunity.
Source: Nature Immunology - Category: Allergy & Immunology Authors: Mandy J McGeachy Tags: News and Views Source Type: research