Assessment of retinol-binding protein 4 in patients with alopecia areata and androgenetic alopecia
Conclusion: The level of RBP4 was found to be increased in serum of both AA and androgenetic alopecia patients. The role of RBP4 may be as a nonspecific molecule leading to hair loss or miniaturization through controlling hair cycle. However, the exact role of RBP4 in the hair cycle and its clinical significance in treatment of AA remains to be elucidated. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2016 Category: Dermatology Tags: Original articles Source Type: research
Prurigo nodularis – an update on an important disease
Prurigo nodularis (PN) is defined as a clinical pattern of mostly symmetrically papules and nodules and belongs to the group of chronic pruritic diseases. Underlying diseases can be skin diseases (e.g. atopic dermatitis or lichen planus), internal medical diseases (e.g. hepatic or renal diseases), and neurological or psychiatric diseases. Recently, new insights into the pathogenesis of PN have revealed an important role of various neuropeptides such as substance P in the maintenance of the itch–scratch cycle of PN. As a consequence, new clinical trials are being conducted to verify a potential benefit by blocking these s...
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2016 Category: Dermatology Tags: Review article Source Type: research
What is your diagnosis?
No abstract available (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2016 Category: Dermatology Tags: Quiz Source Type: research
Serum BAFF and peripheral blood CD19+ B-lymphocytes in generalized vitiligo and relation to disease activity
Background: The currently available evidence supports an autoimmune etiology for generalized vitiligo. B-lymphocytes and B-lymphocyte-activating factor of the tumor necrosis factor family (BAFF) are known to play a role not only in the pathogenesis but also in the progression of autoimmune diseases.
Objective: To determine serum BAFF and peripheral blood CD19+ B-cells in generalized vitiligo and to examine their association with disease severity, activity, duration, and patients’ sex and age.
Patients and methods: A total of 50 generalized vitiligo patients and 38 healthy control participants were included in the study...
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2016 Category: Dermatology Tags: Original articles Source Type: research
Association between serum nitric oxide and Epstein–Barr virus in patients with systemic lupus erythematosus: a case–control study
Conclusion: Adult SLE patients had higher frequencies of EBV-DNA, EBV IgG and NO levels compared with healthy controls. Exposure to EBV could be associated with the increased activity of SLE (higher SLEDAI) rather than the development of the disease, and the increased NO could be a mediator of this. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2016 Category: Dermatology Tags: Original articles Source Type: research
Assessment of serum levels of cathelicidin and vitamin D in acne vulgaris
Conclusion: Significantly higher serum cathelicidin levels were detected in acne patients compared with controls, suggesting that cathelicidin may play a role in the pathogenesis of acne vulgaris and may provide a possible therapeutic target for future treatment. In addition, lower (although nonsignificant) serum vitamin D levels were detected in patients, suggesting a possible role for vitamin D supplementation in acne treatment. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2016 Category: Dermatology Tags: Original articles Source Type: research
Low levels of serum vitamin D3 in chronic spontaneous urticaria patients: relation with clinical characteristics
Conclusion: Current evidence supports a role for vitamin D3 in the pathophysiology of CSU. Although serum levels of vitamin D3 did not influence disease duration, autoreactivity, and angioedema development, they did influence disease severity and response to treatment. Routine screening for its deficiency needs to be considered, and its prognostic and therapeutic value needs evaluation. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2016 Category: Dermatology Tags: Original articles Source Type: research
Assessment of the role of direct immunofluorescence of the outer root sheath in the diagnosis of pemphigus patients
Conclusion: DIF on anagen hair ORS using FITC-labeled anti-human IgG promises to be a sensitive and specific tool for diagnosis of pemphigus; yet its reliability in follow-up of pemphigus patients needs further assessment. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2016 Category: Dermatology Tags: Original articles Source Type: research
Expression of programmed cell death protein 4 in nonmelanoma skin cancer compared with psoriasis and normal skin, a preliminary study
Conclusion: This study preliminarily supports a potential role of PDCD4 in the suppression of nonmelanoma skin cancer. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2016 Category: Dermatology Tags: Original articles Source Type: research
Serum levels of IL-12 and IL-23 in psoriatic patients with or without concomitant hepatitis C: a comparative study
Conclusion: IL-23 overproduction in psoriasis appears to be accentuated by concomitant HCV infection. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2016 Category: Dermatology Tags: Original articles Source Type: research
Histopathological evidence of involvement of eccrine sweat glands in adverse cutaneous drug reactions
Background: Involvement of eccrine sweat glands in adverse cutaneous drug reactions (ACDRs) has not received sufficient interest.
Objective: To examine histopathological changes in eccrine sweat glands in ACDRs.
Patients and methods: Forty ACDR cases were recruited. Lesional and nonlesional biopsies underwent thorough histopathological evaluation of the eccrine apparatus.
Results: The eccrine apparatus was involved in 97.5% of lesional skin biopsies, secretory coils most frequently, and in 42.1% of apparently normal skin biopsies, and the difference was statistically significant (P (Source: Journal of the Egyptian Women...
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2016 Category: Dermatology Tags: Original articles Source Type: research
Topical brimonidine tartrate as a novel treatment for facial erythema of rosacea and acne erythema
Conclusion: Topical brimonidine is considered both effective and safe in the treatment of postacne erythema as well as rosacea erythema. It could be considered as a therapeutic alternative to laser therapy for patients with the above-mentioned diseases. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2016 Category: Dermatology Tags: Original articles Source Type: research
Overview of Mohs micrographic surgery for the treatment of skin cancers
Mohs micrographic surgery is a specialized surgical technique for the treatment of skin cancers. The procedure was developed by Dr Frederic Mohs in the 1930s at the University of Wisconsin and, since then, its use has spread worldwide. The utility of Mohs surgery is based on the fact that cutaneous neoplasms grow in unpredictable, root-like extensions and often vary in both breadth and depth. The advantage of Mohs surgery over traditional skin cancer treatments in that it enables highly precise histologic margin control of deep and peripheral margins of cancerous tissue, with maximal preservation of normal tissue. Therefor...
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2016 Category: Dermatology Tags: Review article Source Type: research
Linear unilateral basal cell nevus with comedones (linear nevoid basaloid follicular hamartoma): a case report
We report the case of an 18-year-old male patient who presented with a 6-month-duration lesion affecting the left side of his trunk in a linear and dermatomal pattern. The lesion was composed of comedones, papules, and hypopigmented macules. Histopathological examination revealed a basaloid follicular hamartoma-like picture, and a diagnosis of linear unilateral basal cell nevus with comedones (linear nevoid basaloid follicular hamartoma) was made. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - January 1, 2016 Category: Dermatology Tags: Case reports Source Type: research
Granular cell tumor: a report of three cases with different clinical presentations
We report three cases of granular cell tumor that showed different clinical presentations. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - January 1, 2016 Category: Dermatology Tags: Case reports Source Type: research
