Lesional levels of superoxide dismutase and malondialdehyde in paucibacillary and multibacillary leprosy patients
Background
Leprosy or Hansen’s disease (HD) is a chronic infectious disease caused by Mycobacterium leprae. The ratio of malondialdehyde (MDA)/superoxide dismutase (SOD) may be considered as an index of oxidative stress (OS).
Objective
To assess the OS by estimating the levels of antioxidant enzyme (SOD), lipid peroxidation products (MDA) and the ratio of MDA/SOD in the skin of paucibacillary (PB) and multibacillary (MB) leprosy patients.
Patients and methods
This case-control study was conducted on 41 untreated leprosy patients (18 patients with PB type and 23 patients with MB type) attending Sohag’s Dermatolo...
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Original articles Source Type: research
Spectrum of spitzoid neoplasms: genetic aberrations and diagnostic tools reappraisal
The objective of this study was to review the current literature concerning spitzoid melanocytic neoplasms and present the most current perspective regarding common fusions found in spitzoid neoplasms along with common genetic diagnostic approaches. BAP1, ALK, NTRK1, NTRK3, BRAF, ROS1, and HRAS have been associated with spitzoid melanocytic neoplasms, and common histological findings, types of cancers associated with these mutations, and mechanism of action are discussed. The utility of P16 immunostain, fluorescence in-situ hybridization, and comparative genomic hybridization as ancillary tests are described, as well as ho...
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Review article Source Type: research
What is your diagnosis?
No abstract available (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Quiz Source Type: research
Case report: lymphedema vulva secondary to hidradenitis suppurativa
Lymphedema of vulva is a rare entity characterized by chronic and progressive engorgement of tissues. It is a diagnostic challenge which is frequently untreated or treated at a late stage. The condition is highly debilitating because of the physical difficulty and mental agony associated with it. There are various underlying causes of lymphedema vulva but the association of lymphedema vulva and hidradenitis suppurativa (HS) is not well recognized. We would like to share the case report of a 35 year old female patient who developed vulval lymphoedema as a complication of longstanding HS. (Source: Journal of the Egyptian Wom...
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Case report Source Type: research
Serum vitamin D level in Egyptian children with atopic dermatitis and efficacy of vitamin D supplementation
Conclusion: Serum levels of 25(OH)D were significantly lower in patients than the controls and vitamin D deficiency is related to the severity of AD, suggesting a therapeutic benefit from oral vitamin D supplementation in improvement of disease severity. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Original articles Source Type: research
Evaluation of efficacy of an intralesional injection of Candida antigen in the treatment of molluscum contagiosum
Background: Different treatment modalities are available for molluscum contagiosum (MC). However, these modalities are often traumatic for children and associated with frequent recurrence.
Objective: To evaluate the efficacy and safety of an intralesional injection of Candida antigen in the treatment of MC.
Patients and methods: Sixteen patients with multiple MC lesions were subjected to intralesional immunotherapy with 0.3 ml of Candida albicans antigen after previous intradermal skin testing for existing immunity. Also, 16 MC patients were subjected to an intralesional neutral saline injection as a control group. All i...
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Original articles Source Type: research
Endocan level in serum and lesional skin of psoriasis vulgaris patients
Background: It is proven that severe psoriasis might be associated with an increased mortality rate because of a higher prevalence of metabolic syndrome and cardiovascular disorders. Endocan is a human cell-specific molecule that is expressed by the vascular endothelium. Endothelial dysfunction is widely accepted as being involved in the development of psoriasis, as well as atherosclerosis.
Objective: To investigate serum and tissue levels of endocan in psoriatic patients versus nonpsoriatic controls, as it may have a role in the pathogenesis of psoriasis, and to correlate these levels to psoriasis area severity index sco...
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Original articles Source Type: research
Levels of osteopontin in plasma and tissue in relation to metabolic status in patients with lichen planus
Conclusion: The presence of LP in patients was associated strongly with MetS parameters, most probably because of long-standing inflammation. OPN may be a critical regulator of chronic inflammation in patients with LP and may explain its association with components of the MetS such as diabetes mellitus and dyslipidemia. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Original articles Source Type: research
Relationship between lipase enzyme and antimicrobial susceptibility of Staphylococcus aureus-positive and Staphylococcus epidermidis-positive isolates from acne vulgaris
Conclusion: Although, Staphylococci spp. isolated from acne lesions showed lipase activity and high prevalent rates of antimicrobial resistance, the association between lipase enzyme and antibiotic susceptibility was statistically insignificant. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Original articles Source Type: research
Increased density of CD1a+ Langerhans cells and CD86+ cells in perilesional and lesional psoriatic skin: an immunohistochemical study
Conclusion: The prominent density of CD1a+ and CD86+ DC in the perilesional skin compared with the lesional psoriatic skin suggests the pathogenetic role of these cells in the initiation of plaque psoriasis. The simultaneous presence and close localization of CD1a+ and CD86+ cells in the psoriatic dermal and epidermal compartments suggests that their interaction potentially contributes to the development of psoriasis. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Original articles Source Type: research
Lesional levels of superoxide dismutase and malondialdehyde in paucibacillary and multibacillary leprosy patients
Background: Leprosy or Hansen’s disease (HD) is a chronic infectious disease caused by Mycobacterium leprae. The ratio of malondialdehyde (MDA)/superoxide dismutase (SOD) may be considered as an index of oxidative stress (OS).
Objective: To assess the OS by estimating the levels of antioxidant enzyme (SOD), lipid peroxidation products (MDA) and the ratio of MDA/SOD in the skin of paucibacillary (PB) and multibacillary (MB) leprosy patients.
Patients and methods: This case-control study was conducted on 41 untreated leprosy patients (18 patients with PB type and 23 patients with MB type) attending Sohag’s Dermatology ...
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Original articles Source Type: research
Spectrum of spitzoid neoplasms: genetic aberrations and diagnostic tools reappraisal
The objective of this study was to review the current literature concerning spitzoid melanocytic neoplasms and present the most current perspective regarding common fusions found in spitzoid neoplasms along with common genetic diagnostic approaches. BAP1, ALK, NTRK1, NTRK3, BRAF, ROS1, and HRAS have been associated with spitzoid melanocytic neoplasms, and common histological findings, types of cancers associated with these mutations, and mechanism of action are discussed. The utility of P16 immunostain, fluorescence in-situ hybridization, and comparative genomic hybridization as ancillary tests are described, as well as ho...
Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2017 Category: Dermatology Tags: Review article Source Type: research
Crosswords
No abstract available (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2017 Category: Dermatology Tags: Crosswords Source Type: research
Prevention of postoperative scars in dark skin types using a fractional carbon dioxide laser: a clinical and histopathological split-scar study
Background: Treatment of mature postoperative scars is frustrating for both patients and doctors. Accordingly, a fractional carbon dioxide (CO2) laser could be used during the early postoperative period as a prophylaxis against scarring. However, its safety in patients with dark skin types and the histopathological changes during early treatment remain controversial.
Objective: To evaluate the efficacy and safety of a fractional CO2 laser in the prevention of postoperative scars in patients with dark skin types, with assessment of its histopathological effect.
Patients and methods: Six fractional CO2 laser sessions were ...
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2017 Category: Dermatology Tags: Original articles Source Type: research
Aquaporin-3 expression in common hyperproliferative skin disorders: an immunohistochemical study
Conclusion: The AQP-3 expression was downregulated in the disease groups as compared with normal human skin from the control group, and was decreased in poorly differentiated tumor cells compared with differentiated tumor cells, suggesting that AQP-3 may have a role in the differentiation of these tumors more than proliferation. Therefore, AQP-3 may be considered as an antihyperproliferative prodifferentiative marker. (Source: Journal of the Egyptian Women’s Dermatologic Society)
Source: Journal of the Egyptian Women’s Dermatologic Society - May 1, 2017 Category: Dermatology Tags: Original articles Source Type: research
